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Technic and Application of Drying of Viruses in the Frozen State

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Handbuch der Virusforschung

Abstract

Freezing quickly has been applied to various biological products like viruses to prevent alteration in chemical and biological characteristics before drying. No eutectic separation with resulting concentration of components occurs. This is in contrast with slow freezing, where two or more phases are obtained, one separating out first with solvent less rich in solute and the remaining liquid phase richer in solute. In the case of cellular materials, disruption of cell walls is avoided. Virus molecules, which frequently are large and relatively labile, are locked in place as a result of quickfreezing so that denaturation of protein and other changes do not occur. Viability is maintained.

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Author information

Authors and Affiliations

  1. Forest Grove, Pennsylvania, USA

    Earl W. Flosdorf

Authors
  1. Earl W. Flosdorf
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Editor information

Editors and Affiliations

  1. Basel, Schweiz

    R. Doerr

  2. Bern, Schweiz

    C. Hallauer

  3. Melbourne, Australien

    F. M. Burnet

  4. Boston, Mass., USA

    M. D. Eaton

  5. Cleveland, O., USA

    A. E. Feller

  6. Forest Grove, PA., USA

    E. W. Flosdorf

  7. Ann Arbor, Mich., USA

    Th. Francis

  8. Wien, Österreich

    M. Kaiser

  9. Dahlem, Berlin, Deutschland

    H. Ruska

  10. Rheinau, Deutschland

    P. Vonwiller

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© 1950 Springer-Verlag in Vienna

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Flosdorf, E.W. (1950). Technic and Application of Drying of Viruses in the Frozen State. In: Doerr, R., et al. Handbuch der Virusforschung. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5688-9_2

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  • DOI: https://doi.org/10.1007/978-3-7091-5688-9_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-5690-2

  • Online ISBN: 978-3-7091-5688-9

  • eBook Packages: Springer Book Archive

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