Absence of free core antigen in anti-HBc negative viremic hepatitis B carriers

  • Ch. Possehl
  • R. Repp
  • K.-H. Heermann
  • E. Korec
  • A. Uy
  • W. H. Gerlich
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

Using enzyme immune assay and immune electron microscopy, we have examined the sera of immune-suppressed anti-HBc negative HBV-infected patients for the presence of HBcAg. Our results suggest that free HBV core particles are absent or present only in minute amounts in the blood of chronic carriers and that at the most, only minimal amounts of core antigen are found on the surface of the virus particles.

Keywords

Virus Particle Core Particle Core Antigen Chronic Carrier Dane Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Möller B, Hopf U, Stemerowicz R, Henze G, Gelderblom H (1989) HBcAg expressed on the surface of circulating Dane particles in patients with hepatitis B virus infection without evidence of anti-HBc formation. Hepatology 10: 179–185Google Scholar
  2. 2.
    Jean-Jean O, Levrero M, Will H, Perricaudet M, Rossignol J-M (1989) Expression mechanism of the hepatitis B virus (HBV) C gene and biosynthesis of HBe antigen. Virology 170: 99–106Google Scholar
  3. 3.
    Bertram U, Fischer HP, Repp R, Willems WR, Lampert F (1990) Hepatitis Endemie bei cytostatisch behandelten Kindern. Dtsch Med Wochenschr 115: 1253–1254Google Scholar
  4. 4.
    Korec E, Korcová J, König J, Hlozánek I (1989) Detection of antibodies against hepatitis B core antigen using the avidin-biotin system. J Virol Meth 24: 321–326Google Scholar
  5. 5.
    Petit MA, Capel F, Riottot MM, Dauguet C, Piilot J (1987) Antigenic mapping of the surface proteins of infectious hepatitis B virus particles. J Gen Virol 68: 2759–2767Google Scholar
  6. 6.
    Heermann K-H, Goldmann U, Schwartz W, Seyffarth T, Baumgarten H, Gerlich WH (1984) Large surface proteins of hepatitis B virus containing the pre-S sequence. J Virol 52: 396–402Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Ch. Possehl
    • 1
  • R. Repp
    • 2
  • K.-H. Heermann
    • 1
  • E. Korec
    • 3
  • A. Uy
    • 1
  • W. H. Gerlich
    • 1
    • 4
  1. 1.Department of Medical MicrobiologyUniversity of GöttingenGermany
  2. 2.Pediatric ClinicUniversity of GiessenFederal Republic of Germany
  3. 3.Institute of Molecular BiologyPragueCSFR
  4. 4.Institute of Medical VirologyUniversity of GiessenGiessenFederal Republic of Germany

Personalised recommendations