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Divergent anti-HBc reactivities in HB-immune and chronic HBsAg carriers

  • U. B. Hellström
  • S. P. E. Sylvan
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

We have monitored titers of anti-HBc antibodies in sera from acutely HBV-infected and chronic HBsAg carriers. Our data show that there is a divergence in the specificity of the antibodies in these two populations. We also present preliminary results showing that serum from HB-immune carriers contain antibodies that are multispecific and display autoimmune characteristics, reacting with human serum albumin.

Keywords

Human Serum Albumin Chronic Carrier Envelope Material Autoimmune Characteristic Chronic HBsAg Carrier 
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References

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    Milich DR, Jones JE, McLachlan A, Houghten R, Thornton GB, Hughes JL (1989) Distinction between immunogenicity and tolerogenicity among HBcAg T cell determinants. J Immunol 143: 3148–3156PubMedGoogle Scholar
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    Milich DR, McLachlan A, Hughes JL, Jones JE, Stahl S, Wingfield P, Thornton GB (1989) Characterization of the hepatitis B virus nucleocapsid as an immunologic carrier moiety. In: Lerner RA, Ginsberg H, Chanock RM, Brown F (eds) Vaccines 89: Modern approaches to new vaccines including prevention of AIDS. Cold Spring Harbor Laboratory, pp 37–42Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • U. B. Hellström
    • 1
  • S. P. E. Sylvan
    • 1
  1. 1.Department of Infectious Diseases, Karolinska InstituteThe Elias Bengtsson Research UnitStockholmSweden

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