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Long-term effects of recombinant leukocyte alpha interferon in the treatment of chronic delta hepatitis

  • G. Tocci
  • L. Antonelli
  • E. Boumis
  • M. Colaiacomo
  • P. Guarascio
  • C. Struglia
  • G. Tossini
  • G. Visco
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

A pilot study is described, in which 25 chronic CDH patients were treated with 3 MU recombinant α-interferon per week for 4 months. Improvement was transient and no long-term effects were noted. Side effects were well tolerated and reversible so that longer treatment and higher dosages should be possible.

Keywords

Liver Biopsy Chronic Active Hepatitis Hepatitis Delta Virus HBeAg Positive Patient Chronic Persistent Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gregory PB (1986) Interferon in chronic hepatitis B. Gastroenterol 90(1): 237–240Google Scholar
  2. 2.
    Hoofnagle J, Mullen K, Peters M, Avigan M, Park Y, Waggoner J, Gerin J, Hoyer B, Smedile A (1987) Treatment of chronic delta hepatitis with recombinant human alpha interferon. Prog Clin Biol Res 234: 291–298PubMedGoogle Scholar
  3. 3.
    Verme G, Amoroso P, Lettieri G, Pierri P, David E, Sessa F, Rizzi R, Bonino F, Recchia S, Rizzetto M (1986) A histological study of the hepatitis delta virus liver disease. Hepatology 6: 1303–1307PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. Tocci
    • 1
  • L. Antonelli
    • 1
  • E. Boumis
    • 1
  • M. Colaiacomo
    • 1
  • P. Guarascio
    • 1
  • C. Struglia
    • 1
  • G. Tossini
    • 1
  • G. Visco
    • 1
  1. 1.Lazzaro Spallanzani Hospital for Infectious DiseasesRomeItaly

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