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Induction of autoantibodies during alpha interferon treatment in chronic hepatitis B

  • Giovanna Fattovich
  • C. Betterle
  • L. Brollo
  • G. Giustina
  • B. Pedini
  • A. Alberti
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

Thirty-two patients with chronic hepatitis B treated with alpha interferon were tested for 12 different antibodies. Only a minority (18%) of cases developed antinuclear antibodies and none developed clinical signs of autoimmune disease. These data suggest that, at the dose regimen used, interferon therapy of chronic hepatitis B is not associated with triggering of autoimmunity.

Keywords

Chronic Hepatitis Alpha Interferon Interferon Therapy Hepatitis Delta Virus Alpha Interferon Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Burman P, Karlsson FA, Oberg K, Alm G (1985) Autoimmune thyroid disease in interferon-treated patients. Lancet ii: 100–101Google Scholar
  2. 2.
    Mayet WJ, Hess G, Gerken G, Rossol S, Voth R, Manns M, Meyer zum Buschenfelde KH (1989) Treatment of chronic type B hepatitis with recombinant-interferon induces autoantibodies not specific for autoimmune chronic hepatitis. Hepatology 10: 24–28Google Scholar
  3. 3.
    Perillo RP (1989) Interferon therapy for chronic typeB hepatitis: The promise comes of age. Gastroenterology 96: 532–536Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Giovanna Fattovich
    • 1
  • C. Betterle
    • 2
  • L. Brollo
    • 1
  • G. Giustina
    • 1
  • B. Pedini
    • 2
  • A. Alberti
    • 1
  1. 1.Istituto Medicina Clinica, Clinica Medica 2aUniversità di PadovaPadovaItaly
  2. 2.Istituto Semeiotica MedicaUniversité di PadovaItaly

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