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Association between HLA class I antigens and response to interferon therapy in children with chronic HBV hepatitis

  • R. Giacchino
  • A. Nocera
  • A. Timitilli
  • E. Cristina
  • G. Giambartolomei
  • F. Caocci
  • C. Cirillo
  • S. Barocci
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

In this preliminary study, children with chronic HBV hepatitis, as was also previously shown for adults, respond to interferon therapy in an HLA class I antigen dependent manner. If this can be confirmed on a large scale, HLA typing may serve as a useful indication of interferon-therapy responders.

Keywords

Chronic Hepatitis Interferon Therapy Chronic Active Liver Disease Delta Infection Pediatric Patient Group 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Forzani B, Actis GC, Verme G (1984) HLA-DR antigens in HBsAg positive chronic active liver disease with and without associated delta infection. Hepatology 4:1107–1110PubMedCrossRefGoogle Scholar
  2. 2.
    Hillis WD, Hillis A, Bias WB, WGB (1977) Association of hepatitis B surface antigenemia with HLA locus B Walker specificities. N Engl J Med 296: 1310–1314PubMedCrossRefGoogle Scholar
  3. 3.
    van Hattum J, Schreuder GMT, Schalm SW (1987) HLA antigens in patients with various courses after hepatitis B virus infection. Hepatology 7: 11–14PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • R. Giacchino
    • 1
  • A. Nocera
    • 3
  • A. Timitilli
    • 1
  • E. Cristina
    • 1
  • G. Giambartolomei
    • 2
  • F. Caocci
    • 1
  • C. Cirillo
    • 1
  • S. Barocci
    • 3
  1. 1.I Clinica Malattie InfettiveUniversità di Genova, Istituto Giannina GasliniGenovaItaly
  2. 2.Divisione di Malttie InfettiveIstituto G. GasliniItaly
  3. 3.Servizio di ImmunologiaOspedale S. MartinoGenoaItaly

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