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Effect of prednisone priming followed by alfa-interferon in treatment of children with chronic hepatitis B: an interim analysis of a controlled trial

  • Riccardo Utili
  • E. Sagnelli
  • G. Giusti
  • G. Ruggiero
  • F. Piccinino
  • B. Galanti
  • L. E. Adinolfi
  • L. Aprea
  • G. Cesaro
  • L. Digilio
  • F. M. Felaco
  • P. Filippini
  • G. B. Gaeta
  • A. Marrone
  • S. Nardiello
  • G. Pasquale
  • T. Pizzella
  • M. Russo
  • L. Santarpia
  • C. Sardaro
  • T. D’Amora
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

A six-month analysis of a controlled trial on the treatment of chronic hepatitis B in children shows that prednisone priming followed by α-interferon 2A was effective in 6 of 9 treated patients in reducing HBV replication and disease activity.

Keywords

Chronic Hepatitis Chronic Persistent Hepatitis Active Viral Replication NANB Hepatitis Prednisone Withdrawal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Giusti G, Ruggiero G, Piccinino F, Galanti B, Sagnelli E, Utili R, Aprea L, Carretta A, Cesaro G, Felaco FM, Filippini P, Gaeta GB, Nardiello S, Pasquale G, Pizzella T, Rosario P, Russo M, Santarpia L, Sardaro C, Digilio L (1989) Long term r IFN oc2a treatment in children with chronic type B hepatitis and active viral replication. A prospective randomized study. Ital J Gastroenterol 21: 95Google Scholar
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    La Banda F, Ruiz Moreno M, Carreno V, Bartolome J, Gutiez G, Ramon Y, Cajal S, Moreno A, Mora I, Porres JC (1988) Recombinant alfa-2 interferon treatment in children with chronic hepatitis B. Lancet i: 250CrossRefGoogle Scholar
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    Lai CL, Lok ASF, Lin HJ, Wu PC, Yeoh EK, Yeung CY (1987) Placebo-controlled trial of recombinant a-2 interferon in Chinese HBsAg carrier children. Lancet ii: 877–880CrossRefGoogle Scholar
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    Lok ASF, Lai CL, Wu PC, Leung EKY (1988) Long term follow up in a randomized controlled trial of recombinant gamma-interferon in Chinese patients with chronic hepatitis B infection. Lancet ii: 298–302CrossRefGoogle Scholar
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    Perrillo RP, Regenstein FG, Peters MG, DeSchryver-Kecskemeti K, Bodicky CJ, Campbell CR, Kuhns MC (1988) Prednisone withdrawal followed by recombinant alpha interferon in the treatment of chronic type B hepatitis. A randomized, controlled trial. Ann Intern Med 109: 95–100Google Scholar
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Riccardo Utili
    • 1
  • E. Sagnelli
    • 1
  • G. Giusti
    • 1
  • G. Ruggiero
    • 1
  • F. Piccinino
    • 1
  • B. Galanti
    • 1
  • L. E. Adinolfi
    • 1
  • L. Aprea
    • 1
  • G. Cesaro
    • 1
  • L. Digilio
    • 1
  • F. M. Felaco
    • 1
  • P. Filippini
    • 1
  • G. B. Gaeta
    • 1
  • A. Marrone
    • 1
  • S. Nardiello
    • 1
  • G. Pasquale
    • 1
  • T. Pizzella
    • 1
  • M. Russo
    • 1
  • L. Santarpia
    • 1
  • C. Sardaro
    • 1
  • T. D’Amora
    • 1
  1. 1.Institute of Medical Therapy, Clinic of Infectious Diseases and Tropical/Subtropical Diseases1st Medical School University of NaplesNapoliItaly

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