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Hepatitis in children with thalassemia major

  • G. Nigro
  • G. Taliani
  • U. Bartmann
  • R. Vitolo
  • T. Perrone
  • S. Mattia
  • P. Pisano
  • A. Petruccelli
  • S. Maiozzi
  • M. Midulla
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

Since thalassemia major patients are transfusion dependent, they are at a particularly high risk of contracting post-transfusion hepatitis. In this study, 36 transfusion-dependent children were followed up for evidence of viral hepatitis. Of 23 with increased ALT levels, 17 were anti-CMV and 12 were anti-HCV positive, 9 were positive for both CMV and HCV. Of 13 children with normal transaminase levels, 5 were CMV positive and 3 were HCV positive. These results show that CMV may be a very common cause of non-A, non-B hepatitis in transfusion dependent thalassemic children.

Keywords

Viral Hepatitis Thalassemic Patient Thalassemia Major Patient Pediatric Institute Serial Serum Sample 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Alter HJ, Purcell RH, Shih JW, Melpolder JC, Houghton M, Choo Q-L, Kuo G (1989) Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med 321: 1494–1500PubMedCrossRefGoogle Scholar
  2. 2.
    Nigro G, Mattia S, Midulla M (1989) Simultaneous detection of specific serum IgM and IgA antibodies for rapid serodiagnosis of congenital or acquired cytomegalovirus infection. Serodiagn Immunother Infect Dis 3: 355–361CrossRefGoogle Scholar
  3. 3.
    Nigro G, Lionetti P, Digilio G, Multari G, Vania A, Midulla M (1990) Viral infections in transfusion-dependent patients with β-thalassemia major: the predominant role of cytomegalovirus. Transfusion 30: 808–813PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. Nigro
    • 1
  • G. Taliani
    • 2
  • U. Bartmann
    • 1
  • R. Vitolo
    • 1
  • T. Perrone
    • 1
  • S. Mattia
    • 1
  • P. Pisano
    • 1
  • A. Petruccelli
    • 1
  • S. Maiozzi
    • 1
  • M. Midulla
    • 1
  1. 1.Institute of Experimental Medicine of the National Council of ResearchPediatric Institute of “La Sapienza” UniversityRomeItaly
  2. 2.Institute of Tropical Diseases“La Sapienza” UniversityRomeItaly

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