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Presence of HCV RNA in serum of asymptomatic blood donors involved in post-transfusion hepatitis (PTH)

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Part of the book series: Archives of Virology ((ARCHIVES SUPPL,volume 4))

Summary

To study the causes of residual posttransfusion hepatitis, serum from implicated donors was tested by PCR for the presence of HCV RNA. Of 20 anti HCV negative donors, 4 were HCV RNA positive and thus, infective. The results suggest that higher-level investigations are necessary for prospective donors who present blood enzyme abnormalities or other questionable characteristics.

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References

  1. Esteban JI, Gonzalez A, Hernandez JM et al (1990) Evaluation of antibodies to hepatitis C virus in a study of transfusion-associated hepatitis. N Engl J Med 323: 1107–1112

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  2. Chomczynski P, Sacchi N (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156–159

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© 1992 Springer-Verlag

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Villa, E. et al. (1992). Presence of HCV RNA in serum of asymptomatic blood donors involved in post-transfusion hepatitis (PTH). In: De Bac, C., Taliani, G., Gerlich, W.H. (eds) Chronically Evolving Viral Hepatitis. Archives of Virology, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5633-9_54

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  • DOI: https://doi.org/10.1007/978-3-7091-5633-9_54

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82350-7

  • Online ISBN: 978-3-7091-5633-9

  • eBook Packages: Springer Book Archive

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