Advertisement

Presence of HCV RNA in serum of asymptomatic blood donors involved in post-transfusion hepatitis (PTH)

  • E. Villa
  • M. Melegari
  • I. Ferretti
  • C. Vecchi
  • P. P. Scaglioni
  • M. De Palma
  • F. Manenti
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

To study the causes of residual posttransfusion hepatitis, serum from implicated donors was tested by PCR for the presence of HCV RNA. Of 20 anti HCV negative donors, 4 were HCV RNA positive and thus, infective. The results suggest that higher-level investigations are necessary for prospective donors who present blood enzyme abnormalities or other questionable characteristics.

Keywords

Blood Donor Prospective Donor Questionable Characteristic Ortho Diagnostic System Positive Blood Donor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Esteban JI, Gonzalez A, Hernandez JM et al (1990) Evaluation of antibodies to hepatitis C virus in a study of transfusion-associated hepatitis. N Engl J Med 323: 1107–1112PubMedCrossRefGoogle Scholar
  2. 2.
    Chomczynski P, Sacchi N (1987) Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156–159PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • E. Villa
    • 1
  • M. Melegari
    • 1
  • I. Ferretti
    • 1
  • C. Vecchi
    • 2
  • P. P. Scaglioni
    • 1
  • M. De Palma
    • 2
  • F. Manenti
    • 1
  1. 1.GastroenterologyUniversity of ModenaModenaItaly
  2. 2.Blood BankUniversity of ModenaItaly

Personalised recommendations