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Chronically Evolving Viral Hepatitis pp 232–233Cite as

Recombinant immunoblot assay for hepatitis C virus antibody in chronic hepatitis

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Part of the book series: Archives of Virology ((ARCHIVES SUPPL,volume 4))

Abstract

Testing for hepatitis C virus by ELISA requires confirmation by recombinant immunoblot assay (RIBA). The first-generation RIBA uses the same antigen as used in the ELISA and one further antigen. A second-generation RIBA in which two further antigens are present, detects positivity that is not found by either the ELISA or the original RIBA. Consequently, although it is adequate to test Elisa positive sera with the first-generation RIBA, the second-generation assay is recommended for confirming negativity.

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References

  1. Skidmore S. Recombinant immunoblot assay for hepatitis C antibody (1990) Lancet 335: 1346

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  2. Van Der Poel CL, Cuypers HTM, Reesink HW et al (1991) Confirmation of hepatitis C virus infection by new four antigen recombinant immunoblot assay. Lancet 337: 317–319

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Author information

Authors and Affiliations

  1. Institute of Tropical Diseases, “La Sapienza” University and Fondazione A. Cesalpino, I Clinica Medica, “La Sapienza” University, Rome, Italy

    Dr. G. Taliani, M. C. Badolato, R. Lecce, C. De Bac, E. De Marzio, C. Balsano, M. Artini & M. Levrero

Authors
  1. Dr. G. Taliani
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  2. M. C. Badolato
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  3. R. Lecce
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  4. C. De Bac
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  5. E. De Marzio
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  6. C. Balsano
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  7. M. Artini
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  8. M. Levrero
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Editor information

Editors and Affiliations

  1. Titolare II Cattedra Clinica, Malattie Tropicli e Infettive, Policlinico Umberto, Roma, Italy

    C. De Bac  & G. Taliani  & 

  2. Institut für Medizinische Virologie, Justus-Leibig-Universität, Giessen, Federal Republic of Germany

    W. H. Gerlich

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© 1992 Springer-Verlag

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Cite this paper

Taliani, G. et al. (1992). Recombinant immunoblot assay for hepatitis C virus antibody in chronic hepatitis. In: De Bac, C., Taliani, G., Gerlich, W.H. (eds) Chronically Evolving Viral Hepatitis. Archives of Virology, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5633-9_50

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  • DOI: https://doi.org/10.1007/978-3-7091-5633-9_50

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82350-7

  • Online ISBN: 978-3-7091-5633-9

  • eBook Packages: Springer Book Archive

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