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Fine specificity of the human T cell response to hepatitis B virus core antigen

  • Amalia Penna
  • A. Bertoletti
  • A. Cavalli
  • A. Valli
  • G. Missale
  • M. Pilli
  • S. Marchelli
  • T. Giuberti
  • P. Fowler
  • F. V. Chisari
  • F. Fiaccadori
  • C. Ferrari
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

The fine specificity of the human T cell response to the hepatitis B virus core antigen (HBcAg) was investigated in 23 patients with acute hepatitis B virus (HBV) infection using a panel of short synthetic peptides covering the entire core region. An immunodominant T cell epitope which was recognized by all except one patient, was identified within the core sequence 50–69. Two further important T cell recognition sites were represented by the amino acid sequences 1–20 and 117–131, which were stimulatory for the T cells of 69% and 73% of the patients, respectively.

T cell recognition of the synthetic peptides was HLA class II restricted because the peptide-induced T cell proliferation was inhibited by anti-HLA class II but not by anti-HLA class I monoclonal antibodies.

These findings may be relevant to the development of future preventive and therapeutic strategies against HBV infection.

Keywords

Cell Epitope Fine Specificity Core Peptide Core Molecule Short Synthetic Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Amalia Penna
    • 1
  • A. Bertoletti
    • 1
    • 2
  • A. Cavalli
    • 1
  • A. Valli
    • 1
  • G. Missale
    • 1
  • M. Pilli
    • 1
  • S. Marchelli
    • 1
  • T. Giuberti
    • 1
  • P. Fowler
    • 2
  • F. V. Chisari
    • 2
  • F. Fiaccadori
    • 1
  • C. Ferrari
    • 1
    • 2
  1. 1.Cattedra Malattie InfettiveUniversité di ParmaParmaItaly
  2. 2.Department of Molecular and Experimental MedicineScripps Clinic and Research FoundationLA JollaUSA

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