Summary
We investigated the prevalence of anti-HCV in 160 consecutive patients with primary biliary cirrhosis. By ELISA, 19 (12%) were positive, as compared to a 68% prevalence in 135 patients with chronic non-A, non-B hepatitis. Serum IgG levels were significantly higher in the anti-HCV positive group. By RIBA, seropositivity was confirmed for 4 patients, whereas 7 were indeterminate. A slight, non-significant reduction of life expectancy was found in anti-HCV positive patients. Until reliable and independent confirmatory tests become available, definitive conclusions on the importance of anti-HCV positivity in primary biliary cirrhosis are improper.
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References
McFarlane IG, Smith HM, Johnson PJ, Bray GP, Vergani D, Williams R (1990) Hepatitis C virus antibodies in chronic active hepatitis: pathogenic factor or false-positive result? Lancet i: 754–757
Esteban JI, Esteban R, Viladomiu L, et al (1989) Hepatitis C virus antibodies among risk groups in Spain. Lancet ii: 294–296
Lenzi M, Ballardini G, Fusconi M, et al (1990) Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet i: 258–259
Kaplan MM (1987) Primary biliary cirrhosis. N Engl J Med 316: 521–528
Housset C, Hirschauer C, Courouce AM, Calvo A, Degos F, Benhamou JP (1990) High prevalence of false positive anti-HCV tests in primary biliary cirrhosis. J Hepatol 11: 30
Schrumpf E, Elgjo K, Fausa O, Haukenes G, Rollag H (1990) The significance of anti-HCV antibodies measured in chronic liver disease. J Hepatol 11: 111
Fusconi M, Lenzi M, Ballardini G, Miniero R, Cassani F, Zauli D, Bianchi FB (1990) Anti-HCV testing in autoimmune hepatitis and primary biliary cirrhosis. Lancet ii: 823
Chiaramonte M, Floreani A, Giacomini A, et al (1990) Anti-HCV in primary biliary cirrhosis. Gut 31: A626
Theilmann L, Blazek M, Goeser T, Gmelin K, Kommerell B, Fiehn W (1990) False-positive anti-HCV tests in rheumatoid arthritis. Lancet ii: 1346
Boudart D, Lucas JC, Müller JY, LeCarrer D, Planchon B, Harousseau JL (1990) False-positive hepatitis C virus antibody tests in paraproteinaemia. Lancet ii: 63
Schaffner F, Popper H (1982) Clinical-pathologic relations in primary biliary cirrhosis. In: Popper H, Schaffner F (eds) Progress in Liver Diseases. Grune and Stratton, New York, pp 529–554
Weiner AJ, Truett MA, Rosenblatt J, et al (1990) HCV testing in low-risk population. Lancet ii: 695
Gray JJ, Wreghitt TG, Friend PJ, Wight DGD, Sundaresan V, Calne RY (1990) Differentiation between specific and non-specific hepatitis C antibodies in chronic liver disease. Lancet i: 609–610
Fleiss JL (1973) Statistical methods for rates and proportions. Wiley, New York
Sirchia G, Bellobuono A, Giovannetti A, Marconi M (1989) Antibodies to hepatitis C virus in italian blood donors. Lancet ii: 797
Giusti G, Galanti B, Gaeta GB (1980) Epidemiology of viral hepatitis in Italy. Boll 1st Sieroter Milan 59: 571–580
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© 1992 Springer-Verlag
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Bertolini, E. et al. (1992). Antibodies to hepatitis C virus in primary biliary cirrhosis. In: De Bac, C., Taliani, G., Gerlich, W.H. (eds) Chronically Evolving Viral Hepatitis. Archives of Virology, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5633-9_43
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DOI: https://doi.org/10.1007/978-3-7091-5633-9_43
Publisher Name: Springer, Vienna
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