Hepatitis C virus (HCV) and autoimmune liver diseases

  • K.-H. Meyer zum Büschenfelde
  • G. Gerken
  • M. Manns
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)


Anti-HCV tests were positive in 18–45% of sera from patients with autoimmune chronic active hepatitis. High gammaglobulin levels may result in false positive results, however, some sera show true positivity. PCR testing of such sera is necessary in order to determine whether HCV is directly involved in specific forms of the disease.


Primary Biliary Cirrhosis Chronic Active Hepatitis Autoimmune Liver Disease Extrahepatic Cholestasis Autoimmune Chronic Active Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Choo OL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M (1989) Isolation of cDNA clone derived from a blood borne non-A, non-B viral hepatitis genome. Science 244: 359–361PubMedCrossRefGoogle Scholar
  2. 2.
    Kuo G, Choo QL, Alter HJ, Gitnick GL, Redeker AG, Purcell RH et al (1989) An assay for circulating antibodies to a major aetiologic virus of human non-A, non-B hepatitis. Science 244: 362–364PubMedCrossRefGoogle Scholar
  3. 3.
    Lenzi M, Ballardini G, Fusconi M, Cassani F, Selleri L, Volta U, Zauli D, Bianchi FB (1990) Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet i: 258–259CrossRefGoogle Scholar
  4. 4.
    McFarlane IG, Smith HM, Johnson PJ, Bray GP, Vergani D, Williams R (1990) Hepatitis C virus antibodies in chronic active hepatitis: pathogenic factor or false positive result? Lancet i: 754–757CrossRefGoogle Scholar
  5. 5.
    Manns M, Gerken G, Kyriatsoulis A, Staritz M, Meyer zum Büschenfelde K-H (1987) Characterization of a new subgroup of autoimmune chronic active hepatitis by autoantibodies against a soluble liver antigen. Lancet i: 292–294CrossRefGoogle Scholar
  6. 6.
    Manns M, Johnson EF, Griffin KJ, Tan EM, Sullivan KF (1989) Major antigen of liver-kidney microsomal autoantibodies in idiopathiac autoimmune hepatitis is cytochrome P450 dbl. J Clin Invest 83: 1066–1072PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • K.-H. Meyer zum Büschenfelde
    • 1
  • G. Gerken
    • 1
  • M. Manns
    • 1
  1. 1.I. Medizinische Klinik und PoliklinikJohannes Gutenberg Universität MainzMainz 1Federal Republic of Germany

Personalised recommendations