T cell recognition of hepatitis B envelope proteins
We have studied the T-cell processing pathways of Hepatitis B antigens and the role of specific B lymphocytes. It could be shown that some form of processing by specific B cells is required for class I CTLs. This mechanism differs from class II endosomal processing. In addition, it could be shown that lysis of HBsAg-specific B cells may be partly responsible for chronic HBV carrier states.
KeywordsEnvelope Protein Processing Pathway Exogenous Antigen Measle Virus Antigen Phase Fluid Pinocytosis
Unable to display preview. Download preview PDF.
- 4.Jin Y, Sih JW, Berkower I (1988) Human T cell response to the surface antigen of hepatitis B virus (HBsAg). J Exp Med 168: 293–306Google Scholar