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Immunogenicity and safety of a recombinant hepatitis B vaccine produced in mammalian cells and containing the S and the preS2 sequences

  • M. P. Corradi
  • C. Tata
  • P. Marchegiano
  • E. Villa
  • M. De Palma
  • G. Trianni
  • L. Fuiano
  • P. Rompianesi
  • T. Scacchetti
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

A group of 273 health care workers, at risk of HBV infection, underwent vaccination with recombinant HBsAg produced in mammalian cells and containing protein sequences coded by both the S and pre-S2 regions (Genhevac B). Preliminary results show that a very early pre-S2 response occurred which may be useful in post-exposure prophylaxis. This observation, in addition to reduced influence by the vaccination protocol, provides grounds for optimism in spite of the fact that the efficiency spectrum of this vaccine was not superior to that of recombinant vaccines produced in yeast.

Keywords

Antibody Response Health Care Worker Recombinant Vaccine Seroconversion Rate Vaccination Protocol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. P. Corradi
    • 1
  • C. Tata
    • 2
  • P. Marchegiano
    • 2
  • E. Villa
    • 2
  • M. De Palma
    • 3
  • G. Trianni
    • 1
  • L. Fuiano
    • 4
  • P. Rompianesi
    • 2
  • T. Scacchetti
    • 2
  1. 1.Direzione SanitariaOspedale Policlinico ModenaModenaItaly
  2. 2.Cattedra di GastroenterologiaOspedale Policlinico ModenaItaly
  3. 3.Servizio ImmunotrasfusionaleOspedale Policlinico ModenaItaly
  4. 4.Istituto Merieux ItaliaRomaItaly

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