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Immune pathogenesis of hepatitis B

  • Conference paper
Chronically Evolving Viral Hepatitis

Part of the book series: Archives of Virology ((ARCHIVES SUPPL,volume 4))

Summary

Available information about the immune pathogenesis of HBV infection in man is very limited. However, the present availability of recombinant sources of the different HBV antigens expressed in the appropriate forms to induce activation of either HLA class I or HLA class II-restricted T cells, provides the necessary tools to investigate directly the mechanisms of liver damage, the role of the different cellular components of the immune system in HBV clearance and the specific nature of the immune defects potentially responsible for the chronic evolution of HBV infection. In addition, improved knowledge of HBV biology suggests a dynamic interpretation of the HBV-immune system interactions, based on which viral mutations as well as direct interferences of HBV with specific immune functions are believed to play a relevant role with respect to the outcome of HBV infection.

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References

  1. Barnaba V, Franco A, Alberti A, Balsano C, Benvenuto R, Balsano F (1989) Recognition of hepatitis B virus envelope proteins by liver-infiltrating T lymphocytes in chronic HBV infection. J Immunol 143: 2650–2655

    PubMed  CAS  Google Scholar 

  2. Barnaba V, Franco A, Alberti A, Benvenuto R, Balsano F (1990) Selective killing of hepatitis B envelope antigen-specific B cells by class I restricted, exogenous antigen specific T lymphocytes. Nature 345: 250–253

    Article  Google Scholar 

  3. Beasley RP, Hwang LY, Stevens CE, Lin CC, Hsieh FJ, Wang KJ, Sun TS, Szmuness W (1983) Efficacy of hepatitis B immune globulin for prevention of perinatal transmission of the hepatitis B virus carrier state. Hepatology 3: 135–141

    Article  PubMed  CAS  Google Scholar 

  4. Brunetto MR, Stemler M, Bonino F, Schödel F, Oliveri F, Rizzetto M, Verme G, Will H (1990) A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol 10: 258–261

    Article  PubMed  CAS  Google Scholar 

  5. Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Markis A, Thomas HC (1989) Mutation preventing formation of hepatitis B e antigen in patients with chronic hepatitis B infection. Lancet ii: 588–591

    Article  Google Scholar 

  6. Carman WF, Zanetti AR, Karayiannis P, Waters J, Manzillo G, Tanzi E, Zuckerman AJ, Thomas HC (1990) Vaccine-induced mutant of hepatitis B virus. Lancet ii: 325–329

    Article  Google Scholar 

  7. Celis E, Ou D, Otvos L (1988) Recognition of hepatitis B surface antigen by human T lymphocytes. J Immunol 140: 1808–1815

    PubMed  CAS  Google Scholar 

  8. Chang LJ, Dienstag J, Ganem D, Varmus H (1989) Detection of antibodies against hepatitis B polymerase antigen in hepatitis B virus-infected patients. Hepatology 10: 332–335

    Article  PubMed  CAS  Google Scholar 

  9. Ferrari C, Mondelli MU, Penna A, Fiaccadori F, Chisari FV (1987) Functional characterization of cloned intrahepatic, hepatitis B virus nucleoprotein-specific helper T cell lines. J Immunol 139: 539–544

    PubMed  CAS  Google Scholar 

  10. Ferrari C, Penna A, Giuberti T, Tong MJA, Ribera E, Fiaccadori F, Chisari FV (1987) Intrahepatic, nucleocapsid antigen-specific T cells in chronic active hepatitis B. J Immunol 139: 2050–2058

    PubMed  CAS  Google Scholar 

  11. Ferrari C, Penna A, Bertoletti A, Valli A, Degli Antoni A, Giuberti T, Ca valli A, Petit MA, Fiaccadori F (1990) Cellular immune response to hepatitis B virus (HBV) encoded antigens in acute and chronic HBV infection. J Immunol 145: 3442–3449

    PubMed  CAS  Google Scholar 

  12. Feitelson MA, Millman I, Duncan GD, Blumberg BS (1988) Presence of antibodies to the polymerase gene product(s) of hepatitis B and woodchuck hepatitis virus in natural and experimental infections. J Med Virol 24: 121–136

    Article  PubMed  CAS  Google Scholar 

  13. McChesney MB, Oldstone MBA (1987) Virus perturb lymphocyte functions: selected principles characterizing virus-induced immunosuppression. Ann Rev Immunol 5: 279–304

    Article  CAS  Google Scholar 

  14. Milich DR, McLachlan A (1986) The nucleocapsid of hepatitis B virus is both a T-cell-dependent and a T-cell-independent antigen. Science 234: 1398–1401

    Article  PubMed  CAS  Google Scholar 

  15. Milich DR, McLachlan A, Thornton GB, Hughes JL (1987) Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site. Nature 329: 547–549

    Article  PubMed  CAS  Google Scholar 

  16. Milich DR, Jones JE, Hughes JL, Price J, Raney A, McLachlan A (1990) Is a function of the secreted hepatitis B e antigen to induce immunological tolerance in utero? Proc Natl Acad Sci USA 87: 6657–6661

    Article  Google Scholar 

  17. Mondelli M, Mieli-Vergani G, Alberti A, Vergani D, Portmann B, Eddieston ALWF, Williams R (1982) Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol 129: 2773–2777

    PubMed  CAS  Google Scholar 

  18. Moriyama T, Guilhot S, Klopchin K, Moss B, Pinkert CA, Palmiter RD, Brinster RL, Kanagawa O, Chisari FV (1990) Immunobiology and pathogenesis of hepatocellular injury in hepatitis B virus transgenic mice. Science 248: 361–364

    Article  PubMed  CAS  Google Scholar 

  19. Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Tanaka T, Miyakawa Y, Mayumi M (1990) Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64: 1298–1303

    PubMed  CAS  Google Scholar 

  20. Onji M, Lever AML, Saito I, Thomas HC (1989) Defective response to interferons in cells transfected with the hepatitis B virus genome. Hepatology 9: 92–96

    Article  PubMed  CAS  Google Scholar 

  21. Penna A, Fowler P, Bertoletti A, Guilhot S, Moss B, Margolskee RF, Cavalli A, Valli A, Fiaccadori F, Chisari FV, Ferrari C (1992) Hepatitis B virus (HBV)-specific cytotoxic T-cell (CTL) response in humans: characterization of HLA class II-restricted CTL that recognize endogenously synthesized HBV envelope antigens. J Virol 66: 1193–1198

    PubMed  CAS  Google Scholar 

  22. Pignatelli M, Waters J, Lever A, Iwarson S, Gerety R, Thomas H (1987) Cytotoxic T cell response to the nucleocapsid proteins of HBV in chronic hepatitis. J Hepatol 4: 15–21

    Article  PubMed  CAS  Google Scholar 

  23. Pircher H, Moskophidis D, Rohrer U, Burki K, Hengartner H, Zinkernagel RM (1990) Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo. Nature 346: 629–633

    Article  PubMed  CAS  Google Scholar 

  24. Schlicht HJ, Shaller H (1989) The secretory core protein of human hepatitis B virus is expressed on the cell surface. J Virol 63: 5399–5404

    PubMed  CAS  Google Scholar 

  25. Shirai M, Hanada H, Kurokouchi K, Watanabe S, Nishioka M (1990) Peripheral blood CD4-mediated enhancement and CD8-mediated suppression in the presence of recombinant hepatitis B virus core antigen. J Infect Dis 161: 420–425

    Article  PubMed  CAS  Google Scholar 

  26. Stemler M, Hess J, Braun R, Will H, Schroder CH (1988) Serological evidence for expression of the polymerase gene of human hepatitis B virus in vivo. J Gen Virol 69: 689–693

    Article  PubMed  CAS  Google Scholar 

  27. Stemler M, Weimer T, Tu SX, Wan DF, Levrero M, Jung C, Pape GR, Will H (1990) Mapping of B-cell epitopes of the human hepatitis B virus X protein. J Hepatol 64: 2802–2809

    CAS  Google Scholar 

  28. Stephan W, Prince A, Brotman B (1984) Modulation of hepatitis B infection by intravenous application of an immunoglobulin preparation that contains antibodies to hepatitis B e and core antigens but not to hepatitis B surface antigen. J Virol 51:420–424

    PubMed  CAS  Google Scholar 

  29. Van Den Oord J, de Vos R, Desmet VJ (1986) In situ distribution of major histocompatibility complex products and viral antigens in chronic hepatitis B virus infection: evidence that HBc-containing hepatocytes may express HLA-DR antigens. Hepatology 6: 981–989

    Article  PubMed  Google Scholar 

  30. Vento S, Hegarty JE, Alberti A, O’Brein CJ, Alexander GJM, Eddleston ALWF, Williams R (1985) T lymphocyte sensitization to HBcAg and T cell-mediated unresponsiveness to HBsAg in hepatitis B virus-related chronic liver disease. Hepatology 5: 192–197

    Article  PubMed  CAS  Google Scholar 

  31. Weimer T, Weimer K, Tu ZX, Jung C, Pape GR, Will H (1989) Immunogenicity of human hepatitis B virus P-gene derived proteins. J Immunol 143: 3750–3756

    PubMed  CAS  Google Scholar 

  32. Yamauchi K, Nakanjshi T, Chiou S, Obata H (1988) Suppression of hepatitis B antibody synthesis by factor made by T cells from chronic hepatitis B carriers. Lancet i: 324–326

    Article  Google Scholar 

  33. Yuki N, Hayashi N, Kasahara A, Katayama K, Ueda K, Fusamoto H, Kamada T (1990) Detection of antibodies against the polymerase gene product in hepatitis B virus infection. Hepatology 12: 193–198

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Cattedra Malattie Infettive, Università di Parma, Via Gramsci 14, 1-43100, Parma, Italy

    C. Ferrari, Dr. Amalia Penna, A. Bertoletti, A. Cavalli, A. Valli, G. Missale, M. Pilli, S. Marchelli, T. Giuberti & F. Fiaccadori

  2. Department of Molecular and Experimental Medicine, Scripps Clinic and Research Foundation, La Jolla, CA, USA

    C. Ferrari & A. Bertoletti

Authors
  1. C. Ferrari
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  2. Dr. Amalia Penna
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  3. A. Bertoletti
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  4. A. Cavalli
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  5. A. Valli
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  6. G. Missale
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  7. M. Pilli
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  8. S. Marchelli
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  9. T. Giuberti
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  10. F. Fiaccadori
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Editor information

Editors and Affiliations

  1. Titolare II Cattedra Clinica, Malattie Tropicli e Infettive, Policlinico Umberto, Roma, Italy

    C. De Bac  & G. Taliani  & 

  2. Institut für Medizinische Virologie, Justus-Leibig-Universität, Giessen, Federal Republic of Germany

    W. H. Gerlich

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© 1992 Springer-Verlag

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Ferrari, C. et al. (1992). Immune pathogenesis of hepatitis B. In: De Bac, C., Taliani, G., Gerlich, W.H. (eds) Chronically Evolving Viral Hepatitis. Archives of Virology, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5633-9_3

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  • DOI: https://doi.org/10.1007/978-3-7091-5633-9_3

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82350-7

  • Online ISBN: 978-3-7091-5633-9

  • eBook Packages: Springer Book Archive

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