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Clinical significance of the polymerase chain reaction (PCR) assay in chronic HBV carriers

  • G. Gerken
  • P. Paterlini
  • D. Kremsdorf
  • M. A. Petit
  • M. Manns
  • K.-H. Meyer zum Büschenfelde
  • C. Brechot
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

PCR was evaluated as a clinical tool for use in accurate identification of the specific etiologic agent in chronic HBV carriers. The method was found to be valuable in diagnosis and for monitoring therapy, as well as for elucidation of genotypic variants of HBV in chronic HBV cases. By this means an HBV defective variant with alterations in the preSl/preS2 sequence was detected and is consequently described here.

Keywords

Polymerase Chain Reaction Assay Primary Hepatocellular Carcinoma HBsAg Carrier preS Gene Asymptomatic HBsAg Carrier 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. Gerken
    • 1
    • 2
  • P. Paterlini
    • 2
  • D. Kremsdorf
    • 2
  • M. A. Petit
    • 3
  • M. Manns
    • 1
  • K.-H. Meyer zum Büschenfelde
    • 1
  • C. Brechot
    • 2
    • 4
  1. 1.I. Medizinische Klinik und Poliklinik der Johannes Gutenberg-UniversitätMainzFederal Republic of Germany
  2. 2.INSERM Unité 75CHU NeckerParis Cedex 15France
  3. 3.INSERM U 131ClamartFrance
  4. 4.Laboratoire HybridtestInstitut PasteurParisFrance

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