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Relapsing hepatitis A in Saimiri monkeys experimentally reinfected with a wild type hepatitis A virus (HAV)

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Chronically Evolving Viral Hepatitis

Part of the book series: Archives of Virology ((ARCHIVES SUPPL,volume 4))

Summary

Saimiri monkeys were inoculated three times with hepatitis A virus and observed in a follow-up study for sixteen months. The monkeys developed recurrent hepatitis involving liver damage and cycles of HAV antigen shedding in stools. The relapses were presumably due to immune response effects.

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References

  • Cohen JI, Feinstone S, Purcell RH (1989) Hepatitis A virus infection in a chimpanzee: Duration of viremia and detection of virus in saiiva and throat swabs. J Infect Dis 160: 887–890

    Google Scholar 

  • Fagan E, Yousef G, Brahm J, Garelick H, Mann G, Wolstenholme A, Portmann B, Harrison T, Mowbray JF, Mowat A, Zuckerman A, Williams R (1990) Persistence of hepatitis A virus in fulminant hepatitis and after liver transplantation. J Med Virol 30: 131–136

    Article  PubMed  CAS  Google Scholar 

  • Gordon SC, Reddy KR, Schiff L, Schiff ER (1984) Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Ann Intern Med 101: 635–637

    PubMed  CAS  Google Scholar 

  • Jacobson IM, Nath BJ, Dienstag JL (1985) Relapsing viral hepatitis type A. J Med Virol 16: 163–169

    Article  PubMed  CAS  Google Scholar 

  • Karayiannis P, Jowett T, Enticott M, Moore D, Pignatelli M, Brenes F, Scheuer PJ, Thomas HC (1986) Hepatitis A virus replication in Tamarins and host immune response in relation to pathogenesis of liver cell damage. J Med Virol 18: 261–276

    Article  PubMed  CAS  Google Scholar 

  • Karayiannis P, Chitranukroh R, Fry M, Petrovic LM, Moore D, Scheuer PJ, Thomas HC (1990) Protracted alanine aminotransferase levels in tamarins infected with hepatitis A virus. J Med Virol 30: 151–158

    Article  PubMed  CAS  Google Scholar 

  • Mathiesen LR, Moller AM, Purcell RH, London WT, Feinstone SM (1980) Hepatitis A virus in the liver and intestine of marmosets after oral inoculation. Infect Immun 28: 45–48

    PubMed  CAS  Google Scholar 

  • Miller Keenan C, Lemon SM, Le Duc JW, McNamee GA, Binn LN (1984) Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus). Am J Pathol 115: 1–8

    Google Scholar 

  • Murphy BL, Maynard JE, Bradley DW, Ebert JW, Mathiesen LR, Purcell RH (1978) Immunofluorescence of hepatitis A virus antigen in chimpanzees. Infect Immun 21: 663–665

    PubMed  CAS  Google Scholar 

  • Prevot J, Kopecka H (1988) HAV detection by molecular hybridization and ELISA. In: Zuckerman A (ed) Viral hepatitis and liver disease. Alan R Liss, New York, pp 70–73

    Google Scholar 

  • Raimondo G, Longo G, Caredda F, Saracco G, Rizetto M (1986) Prolonged, polyphasic infection with hepatitis A. J Infect Dis 153: 172–173

    Article  PubMed  CAS  Google Scholar 

  • Sjogren MH, Tanno H, Fay O, Sileoni S, Cohen BD, Burke DS, Feighny RJ (1987) Hepatitis A virus in stool during clinical relapse. Ann Intern Med 106: 221–226

    PubMed  CAS  Google Scholar 

  • Vallbracht A, Maier K, Stierhof YD, Wiedmann KH, Flehmig B, Fleischer B (1989) Liver-derived cytotoxic T cells in hepatitis A virus infection. J Infect Dis 160: 209–217

    Article  PubMed  CAS  Google Scholar 

  • Van den Anker JN, Sukhai RN, Dumas AM (1988) Relapsing hepatitis in a child associated with isolation of hepatitis A virus antigen from the liver. Eur J Pediatr 147: 333

    Article  PubMed  Google Scholar 

  • Zamyatina NA, Andzhaparidze AG, Balayan MS, Sobol AV, Titova IP, Karetnyi YV, Poleschuk VF (1990) Development of infection in monkeys as a result of successive natural and experimental infection with hepatitis A virus. Vopr Virusol 35: 122

    Google Scholar 

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© 1992 Springer-Verlag

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Prevot, S., Marechal, J., Piilot, J., Prevot, J. (1992). Relapsing hepatitis A in Saimiri monkeys experimentally reinfected with a wild type hepatitis A virus (HAV). In: De Bac, C., Taliani, G., Gerlich, W.H. (eds) Chronically Evolving Viral Hepatitis. Archives of Virology, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5633-9_2

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  • DOI: https://doi.org/10.1007/978-3-7091-5633-9_2

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-82350-7

  • Online ISBN: 978-3-7091-5633-9

  • eBook Packages: Springer Book Archive

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