Advertisement

Relapsing hepatitis A in Saimiri monkeys experimentally reinfected with a wild type hepatitis A virus (HAV)

  • S. Prevot
  • J. Marechal
  • J. Piilot
  • J. Prevot
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

Saimiri monkeys were inoculated three times with hepatitis A virus and observed in a follow-up study for sixteen months. The monkeys developed recurrent hepatitis involving liver damage and cycles of HAV antigen shedding in stools. The relapses were presumably due to immune response effects.

Keywords

Liver Biopsy Vero Cell Intrahepatic Cholestasis Hepatocyte Necrosis Necrotic Hepatocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Cohen JI, Feinstone S, Purcell RH (1989) Hepatitis A virus infection in a chimpanzee: Duration of viremia and detection of virus in saiiva and throat swabs. J Infect Dis 160: 887–890Google Scholar
  2. Fagan E, Yousef G, Brahm J, Garelick H, Mann G, Wolstenholme A, Portmann B, Harrison T, Mowbray JF, Mowat A, Zuckerman A, Williams R (1990) Persistence of hepatitis A virus in fulminant hepatitis and after liver transplantation. J Med Virol 30: 131–136PubMedCrossRefGoogle Scholar
  3. Gordon SC, Reddy KR, Schiff L, Schiff ER (1984) Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Ann Intern Med 101: 635–637PubMedGoogle Scholar
  4. Jacobson IM, Nath BJ, Dienstag JL (1985) Relapsing viral hepatitis type A. J Med Virol 16: 163–169PubMedCrossRefGoogle Scholar
  5. Karayiannis P, Jowett T, Enticott M, Moore D, Pignatelli M, Brenes F, Scheuer PJ, Thomas HC (1986) Hepatitis A virus replication in Tamarins and host immune response in relation to pathogenesis of liver cell damage. J Med Virol 18: 261–276PubMedCrossRefGoogle Scholar
  6. Karayiannis P, Chitranukroh R, Fry M, Petrovic LM, Moore D, Scheuer PJ, Thomas HC (1990) Protracted alanine aminotransferase levels in tamarins infected with hepatitis A virus. J Med Virol 30: 151–158PubMedCrossRefGoogle Scholar
  7. Mathiesen LR, Moller AM, Purcell RH, London WT, Feinstone SM (1980) Hepatitis A virus in the liver and intestine of marmosets after oral inoculation. Infect Immun 28: 45–48PubMedGoogle Scholar
  8. Miller Keenan C, Lemon SM, Le Duc JW, McNamee GA, Binn LN (1984) Pathology of hepatitis A infection in the owl monkey (Aotus trivirgatus). Am J Pathol 115: 1–8Google Scholar
  9. Murphy BL, Maynard JE, Bradley DW, Ebert JW, Mathiesen LR, Purcell RH (1978) Immunofluorescence of hepatitis A virus antigen in chimpanzees. Infect Immun 21: 663–665PubMedGoogle Scholar
  10. Prevot J, Kopecka H (1988) HAV detection by molecular hybridization and ELISA. In: Zuckerman A (ed) Viral hepatitis and liver disease. Alan R Liss, New York, pp 70–73Google Scholar
  11. Raimondo G, Longo G, Caredda F, Saracco G, Rizetto M (1986) Prolonged, polyphasic infection with hepatitis A. J Infect Dis 153: 172–173PubMedCrossRefGoogle Scholar
  12. Sjogren MH, Tanno H, Fay O, Sileoni S, Cohen BD, Burke DS, Feighny RJ (1987) Hepatitis A virus in stool during clinical relapse. Ann Intern Med 106: 221–226PubMedGoogle Scholar
  13. Vallbracht A, Maier K, Stierhof YD, Wiedmann KH, Flehmig B, Fleischer B (1989) Liver-derived cytotoxic T cells in hepatitis A virus infection. J Infect Dis 160: 209–217PubMedCrossRefGoogle Scholar
  14. Van den Anker JN, Sukhai RN, Dumas AM (1988) Relapsing hepatitis in a child associated with isolation of hepatitis A virus antigen from the liver. Eur J Pediatr 147: 333PubMedCrossRefGoogle Scholar
  15. Zamyatina NA, Andzhaparidze AG, Balayan MS, Sobol AV, Titova IP, Karetnyi YV, Poleschuk VF (1990) Development of infection in monkeys as a result of successive natural and experimental infection with hepatitis A virus. Vopr Virusol 35: 122Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • S. Prevot
    • 2
  • J. Marechal
    • 1
  • J. Piilot
    • 1
  • J. Prevot
    • 2
  1. 1.Institut Pasteur, Virologie MédicaleUnité de Virologie Médicale, Unité d’Immunologie MicrobienneParis Cedex 15France
  2. 2.Service d’Anatomie et de Cytologie PathologiquesParisFrance

Personalised recommendations