Hepatitis B virus (HBV) genomic variations in chronic hepatitis
Using PCR we have examined the sequence of the pre-C/C region of HBV from sera of anti-HBe positive, chronically HBV-infected patients. The large majority of sera tested contained a mixture of heterogeneous pre-C sequences with 1–3 non-randomly located point mutations. Some of the resultant variant viruses are incapable of synthesizing immunogenic proteins and may be involved in viral persistence in chronic carrier states.
KeywordsViral Persistence Translational Stop Codon Consiglio Nazionale Delle Ricerche Chronic Carrier State Defective Viral Genome
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