Variants of hepatitis B virus

  • F. Bonino
  • M. R. Brunetto
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)


Variations in the course of disease caused by hepatitis B virus may often be attributed to genomic variants of the virus. It must be kept in mind, however, that other factors, i.e. immunocompetence of the host and new methods of detection such as PCR, may also result in apparently aberrant phenotypic expression. Examples of both situations are presented here and the need is stressed for combined virological, biochemical and clinical studies.


Viral Nucleic Acid Detectable HBsAg HBeAg Carrier Wildtype Virus Molinette Hospital 


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  1. 1.
    Mateu MG, Martinez MA, Rocha E, Andreu D, Parejo J, Giralt E, Sobrino F, Domingo E (1989) Implications of a quasispecies genome structure: effect of frequent naturally occurring amino acids substitutions on the antigenicity of foot-and-mouth disease virus. ad Sci USA 86: 5883–5887CrossRefGoogle Scholar
  2. 2.
    Carman WF, Zanetti AR, Karayannis P, Waters J, Manzillo G, Tanzi E, Zuckerman AJ, Thomas HC (1990) Vaccine-induced escape mutant of hepatitis B virus. Lancet ii: 325–329CrossRefGoogle Scholar
  3. Brunetto MR, Stemler M, Schödel F, Will H, Ottobrelli A, Rizzetto M, Verme G, Bonino F (1989) Identification of HBV variants which cannot produce precore derived HBeAg and may be responsible for severe hepatitis. Ital J Gastroenterol 21: 151–154Google Scholar
  4. 3.
    Brunetto MR, Oliveri FR, Rocca G, Criscuolo D, Chiaberge E, Capalbo M, David E, Verme G, Bonino F (1989) Natural course and response to interferon of chronic type B hepatitis, accompanied by antibody to hepatitis B e antigen. Hepatology 10: 198–203PubMedCrossRefGoogle Scholar
  5. 4.
    Brunetto MR, Stemler M, Bonino F, Schödel F, Oliveri F, Rizzetto M, Verme G, Will H (1990) A new hepatitis B virus strain in patients with severe anti-HBe positive chronic hepatitis B. J Hepatol 10: 258–261PubMedCrossRefGoogle Scholar
  6. 5.
    Carman WF, Jacyna MR, Hadziyannis S, Karayiannis P, McGarvey MJ, Makris A, Thomas HC (1989) Mutation preventing formation of Hepatitis B e antigen in patients with chronic Hepatitis B infection. Lancet ii: 588–591CrossRefGoogle Scholar
  7. 6.
    Okamoto H, Yotsumoto S, Akahane Y, Yamanaka T, Miyazaki Y, Sugai Y, Tsuda F, Mayumi H (1990) Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen. J Virol 64: 1298–1303PubMedGoogle Scholar
  8. 7.
    Tong SP, Li JS, Vitvitski L, Trepo C (1989) The anti-HBe form of chronic active hepatitis B is associated with a stop codon in the pre-C region of the viral genome. In: Marion P, Schaller H (eds) Hepatitis B viruses. Cold Spring Harbor, NY, Cold Spring Harbor Lab, p 138Google Scholar
  9. 8.
    Raimondo G, Schneider R, Stemler M, Smedile A, Wilder G, Rodino G, Schödel F, Squadrito G, Will H (1991) Reactivation and latency of hepatitis B virus in chronically infected patients.Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • F. Bonino
    • 1
  • M. R. Brunetto
    • 1
  1. 1.Division of GastroenterologyMolinette HospitalTorinoItaly

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