Summary
Epidemiological, clinical and laboratory data point to a role of hepatitis C virus infection in hepatocellular carcinoma. The connection appears to be indirect and to be mediated by cirrhosis. Thus, geographical differences can be observed, based on the locally prevalent etiological factors for cirrhosis. In the end, prospective studies of hepatitis C virus infected persons will be needed to elucidate the role of this agent in liver cancer.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Beasley RP (1988) Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61: 1942–1956
Bosch FX, Munoz N (1988) Prospects for epidemiological studies on hepatocellular carcinoma as a model for assessing viral and chemical interactions. In: Bartsch H, Hemminki K, O’Neill IK (eds) Methods for detecting DNA-damaging agents in humans: applications in cancer epidemiology and prevention. IARC Scientific Publication 89, IARC, Lyon, pp 427–438
Bruix J, Barrera JM, Calvet X, Ercilla G, Costa J, Sanchez-Tapias JM, Ventura M, Vail M, Bruguera M, Bru C, Castillo R, Rodes J (1989) Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet ii: 1004–1006
Colombo M, Kuo G, Choo QL, Donato MF, Del Ninno E, Tommasini MA, Dioguardi N, Houghton M (1989) Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet ii: 1006–1009
Dazza MC, Menerses LV, Girard PM, Villaroel C, Brechot C, Larouzè B (1990) Hepatitis C antibody and hepatocellular carcinoma. Lancet i: 1216
Ducreux M, Buffet C, Dussaix EA, Pelletier G, Briantais MJ, Yvart Y, Jaques L, Etienne JP (1990) Antibody to hepatitis C virus in hepatocellular carcinoma. Lancet i: 301
Hasan F, Jeffers LJ, De Medina M, Reddy R, Parker T, Schiff ER, Houghton M, Choo Q, Kuo G (1990) Hepatitis C associated hepatocellular carcinoma. Hepatology 12: 589–591
Johnson PJ and Williams R (1987) Cirrhosis and aetiology of hepatocellular carcinoma. J Hepatol 4: 140–47
Kaneko S, Kuno K, Yanagi M, Unoura M, Hattori N, Murakami S, Kobayashi K (1991) Sequence analysis of hepatitis C virus genomes isolated from five patients with chronic non-A, non-B hepatitis. In: Hollinger FB, Lemon SM, Margolis H (eds) Viral hepatitis and liver disease. Williams & Wilkins, Baltimore, pp 364–367
Kew MC, Houghton M, Choo QL, Kuo G (1990) Hepatitis C virus antibodies in southern African Blacks with hepatocellular carcinoma. Lancet i: 873–874
Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell R, Alter H (1990) Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12: 641–675
Linke HL, Miller MF, Peterson DA, Muchmore E, Lesniewski RR, Carrick RJ, Gagne GD, Popper H (1987) Documentation of hepatocellular carcinoma in a chimpanzee with non-A, non-B hepatitis. In: Robinson W, Koike K, Will H (eds) Hepadna viruses. Liss, New York, pp 357–370
Okuda K, Fujimoto I, Hanai A, Urano Y (1989) Changing incidence of hepatocellular carcinoma in Japan. Cancer Res 47: 4967–4972
Saito I, Miyamura T, Ohbayashi H, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo QL, Houghton M, Kuo G (1990) Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 87: 6547–6549
Sakamoto M, Hirohashi S, Tsuda H, Ino Y, Shimosato Y, Yamasaki S, Makuuchi M, Hasegawa H, Terada M, Hosoda Y (1988) Increasing incidence of hepatocellular carcinoma possibly associated with non-A, non-B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases. Cancer Res 48: 7294–7297
Sbolli G, Zanetti AR, Tanzi E, Cavanna L, Fornari F, Di Stasi M, Buscarini L (1990) Serum antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. J Med Virol 30: 230–232
Simonetti RG, Cottone M, Craxi A, Pagliaro L, Rapicetta M, Chionne M, Costantino A (1989) Prevalence of antibodies to hepatitis C virus in hepatocellular carcinoma. Lancet ii: 1338
Tabor E (1989) Hepatocellular carcinoma: possible etiologies in patients without serologic evidence of hepatitis B virus infection. J Med Virol 27: 1–6
Tremolada F, Benvegnù L, Casarin C, Pontisso P, Tagger A, Alberti A (1990) Antibody to hepatitis C virus in hepatocellular carcinoma. Lancet 335: 300–301
Vargas V, Castells L, Esteban JI (1990) High frequency of antibodies to hepatitis C virus among patients with hepatocellular carcinoma. Ann Intern Med 3: 232–233
Yu MC, Tong M J, Coursaget P, Ross RK, Govindarajan S, Henderson BE (1990) Prevalence of hepatitis B and C viral markers in black and white patients with hepatocellular carcinoma in the United States. J Nat Cancer Inst 82: 1038–1041
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1992 Springer-Verlag
About this paper
Cite this paper
Sangiovanni, A., Covini, G., Rumi, M.G., Marcelli, R., Colombo, M. (1992). Hepatitis C virus and hepatocellular carcinoma. In: De Bac, C., Taliani, G., Gerlich, W.H. (eds) Chronically Evolving Viral Hepatitis. Archives of Virology, vol 4. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5633-9_15
Download citation
DOI: https://doi.org/10.1007/978-3-7091-5633-9_15
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-82350-7
Online ISBN: 978-3-7091-5633-9
eBook Packages: Springer Book Archive