Hepatitis C virus and hepatocellular carcinoma

  • A. Sangiovanni
  • G. Covini
  • M. G. Rumi
  • R. Marcelli
  • M. Colombo
Conference paper
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)


Epidemiological, clinical and laboratory data point to a role of hepatitis C virus infection in hepatocellular carcinoma. The connection appears to be indirect and to be mediated by cirrhosis. Thus, geographical differences can be observed, based on the locally prevalent etiological factors for cirrhosis. In the end, prospective studies of hepatitis C virus infected persons will be needed to elucidate the role of this agent in liver cancer.


Hepatocellular Carcinoma HBsAg Positive Patient NANB Hepatitis Chronic NANB Chronic NANB Hepatitis 


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  1. 1.
    Beasley RP (1988) Hepatitis B virus. The major etiology of hepatocellular carcinoma. Cancer 61: 1942–1956PubMedCrossRefGoogle Scholar
  2. 2.
    Bosch FX, Munoz N (1988) Prospects for epidemiological studies on hepatocellular carcinoma as a model for assessing viral and chemical interactions. In: Bartsch H, Hemminki K, O’Neill IK (eds) Methods for detecting DNA-damaging agents in humans: applications in cancer epidemiology and prevention. IARC Scientific Publication 89, IARC, Lyon, pp 427–438Google Scholar
  3. 3.
    Bruix J, Barrera JM, Calvet X, Ercilla G, Costa J, Sanchez-Tapias JM, Ventura M, Vail M, Bruguera M, Bru C, Castillo R, Rodes J (1989) Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet ii: 1004–1006CrossRefGoogle Scholar
  4. 4.
    Colombo M, Kuo G, Choo QL, Donato MF, Del Ninno E, Tommasini MA, Dioguardi N, Houghton M (1989) Prevalence of antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. Lancet ii: 1006–1009CrossRefGoogle Scholar
  5. 5.
    Dazza MC, Menerses LV, Girard PM, Villaroel C, Brechot C, Larouzè B (1990) Hepatitis C antibody and hepatocellular carcinoma. Lancet i: 1216CrossRefGoogle Scholar
  6. 6.
    Ducreux M, Buffet C, Dussaix EA, Pelletier G, Briantais MJ, Yvart Y, Jaques L, Etienne JP (1990) Antibody to hepatitis C virus in hepatocellular carcinoma. Lancet i: 301Google Scholar
  7. 7.
    Hasan F, Jeffers LJ, De Medina M, Reddy R, Parker T, Schiff ER, Houghton M, Choo Q, Kuo G (1990) Hepatitis C associated hepatocellular carcinoma. Hepatology 12: 589–591PubMedCrossRefGoogle Scholar
  8. 8.
    Johnson PJ and Williams R (1987) Cirrhosis and aetiology of hepatocellular carcinoma. J Hepatol 4: 140–47PubMedCrossRefGoogle Scholar
  9. 9.
    Kaneko S, Kuno K, Yanagi M, Unoura M, Hattori N, Murakami S, Kobayashi K (1991) Sequence analysis of hepatitis C virus genomes isolated from five patients with chronic non-A, non-B hepatitis. In: Hollinger FB, Lemon SM, Margolis H (eds) Viral hepatitis and liver disease. Williams & Wilkins, Baltimore, pp 364–367Google Scholar
  10. 10.
    Kew MC, Houghton M, Choo QL, Kuo G (1990) Hepatitis C virus antibodies in southern African Blacks with hepatocellular carcinoma. Lancet i: 873–874CrossRefGoogle Scholar
  11. 11.
    Kiyosawa K, Sodeyama T, Tanaka E, Gibo Y, Yoshizawa K, Nakano Y, Furuta S, Akahane Y, Nishioka K, Purcell R, Alter H (1990) Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology 12: 641–675CrossRefGoogle Scholar
  12. 12.
    Linke HL, Miller MF, Peterson DA, Muchmore E, Lesniewski RR, Carrick RJ, Gagne GD, Popper H (1987) Documentation of hepatocellular carcinoma in a chimpanzee with non-A, non-B hepatitis. In: Robinson W, Koike K, Will H (eds) Hepadna viruses. Liss, New York, pp 357–370Google Scholar
  13. 13.
    Okuda K, Fujimoto I, Hanai A, Urano Y (1989) Changing incidence of hepatocellular carcinoma in Japan. Cancer Res 47: 4967–4972Google Scholar
  14. 14.
    Saito I, Miyamura T, Ohbayashi H, Harada H, Katayama T, Kikuchi S, Watanabe Y, Koi S, Onji M, Ohta Y, Choo QL, Houghton M, Kuo G (1990) Hepatitis C virus infection is associated with the development of hepatocellular carcinoma. Proc Natl Acad Sci USA 87: 6547–6549PubMedCrossRefGoogle Scholar
  15. 15.
    Sakamoto M, Hirohashi S, Tsuda H, Ino Y, Shimosato Y, Yamasaki S, Makuuchi M, Hasegawa H, Terada M, Hosoda Y (1988) Increasing incidence of hepatocellular carcinoma possibly associated with non-A, non-B hepatitis in Japan, disclosed by hepatitis B virus DNA analysis of surgically resected cases. Cancer Res 48: 7294–7297PubMedGoogle Scholar
  16. 16.
    Sbolli G, Zanetti AR, Tanzi E, Cavanna L, Fornari F, Di Stasi M, Buscarini L (1990) Serum antibodies to hepatitis C virus in Italian patients with hepatocellular carcinoma. J Med Virol 30: 230–232PubMedCrossRefGoogle Scholar
  17. 17.
    Simonetti RG, Cottone M, Craxi A, Pagliaro L, Rapicetta M, Chionne M, Costantino A (1989) Prevalence of antibodies to hepatitis C virus in hepatocellular carcinoma. Lancet ii: 1338CrossRefGoogle Scholar
  18. 18.
    Tabor E (1989) Hepatocellular carcinoma: possible etiologies in patients without serologic evidence of hepatitis B virus infection. J Med Virol 27: 1–6PubMedCrossRefGoogle Scholar
  19. 19.
    Tremolada F, Benvegnù L, Casarin C, Pontisso P, Tagger A, Alberti A (1990) Antibody to hepatitis C virus in hepatocellular carcinoma. Lancet 335: 300–301CrossRefGoogle Scholar
  20. 20.
    Vargas V, Castells L, Esteban JI (1990) High frequency of antibodies to hepatitis C virus among patients with hepatocellular carcinoma. Ann Intern Med 3: 232–233Google Scholar
  21. 21.
    Yu MC, Tong M J, Coursaget P, Ross RK, Govindarajan S, Henderson BE (1990) Prevalence of hepatitis B and C viral markers in black and white patients with hepatocellular carcinoma in the United States. J Nat Cancer Inst 82: 1038–1041PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. Sangiovanni
    • 1
  • G. Covini
    • 1
  • M. G. Rumi
    • 1
  • R. Marcelli
    • 1
  • M. Colombo
    • 1
  1. 1.Institute of Internal MedicineUniversity of MilanMilanItaly

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