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Trans-activation by hepatitis B virus X protein is mediated via a tumour promoter pathway

  • A. S. Kekulé
  • U. Lauer
  • L. Weiß
  • P. H. Hofschneider
  • R. Koshy
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

We have studied the c-myc gene as a possible target of HBV X protein in liver carcinogenesis. Our results indicate that trans-activation by X protein occurs via PKC/AP1 signal transduction, suggesting a possible two-step mechanism in HBV related liver carcinogenesis.

Keywords

Liver Carcinogenesis CCL13 Cell Cellular Protein Kinase Tumour Promoter Pathway Minimal Promoter Construct 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. S. Kekulé
    • 1
  • U. Lauer
    • 1
  • L. Weiß
    • 1
  • P. H. Hofschneider
    • 1
  • R. Koshy
    • 1
  1. 1.Max-Planck-Institut für BiochemieMartinsriedFederal Republic of Germany

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