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The hepatitis B virus X protein transactivation of c-fos and c-myc proto-oncogenes is mediated by multiple transcription factors

  • M. L. Avantaggiati
  • C. Balsano
  • G. Natoli
  • E. De Marzio
  • H. Will
  • E. Elfassi
  • M. Levrero
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)

Summary

We have constructed two expression vectors in order to study the action of the HBV 17 Kd X protein on the c-fos and c-myc promoters. The results show that the promoters contain multiple elements that respond to X protein, suggesting involvement of multiple transcription factors. The exact mechanism of the interaction remains elusive, but our data allow speculation about the factors that may be influenced.

Keywords

Human Immunodeficiency Virus Type Chloramphenicol Acetyl Transferase Multiple Transcription Factor Serum Response Element Protein Transactivation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. L. Avantaggiati
    • 1
  • C. Balsano
    • 1
  • G. Natoli
    • 1
  • E. De Marzio
    • 1
  • H. Will
    • 2
  • E. Elfassi
    • 3
  • M. Levrero
    • 1
  1. 1.Laboratory of Genetic ExpressionFondazione A. Cesalpino, I Clinica MedicaRomeItaly
  2. 2.Max-Planck-Institut für BiochemieMartinsried bei MünchenFederal Republic of Germany
  3. 3.Unitè d’Immunologie MicrobienneInstitute PasteurParisFrance

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