Immune pathogenesis of hepatitis A

  • A. Vallbracht
  • B. Fleischer
Part of the Archives of Virology book series (ARCHIVES SUPPL, volume 4)


In an effort to elucidate the mechanism of liver damage resulting from Hepatitis A virus (HAV) infection, we have studied infected skin fibroblasts and autologous lymphocytes from HAV patients. We report here that HLA-restricted virus-specific T cells play an essential role in HAV-related hepatocellular injury.


Cytolytic Activity Hepatocellular Injury Versus Patient Autologous Lymphocyte Normal Human Hepatocyte 
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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • A. Vallbracht
    • 1
  • B. Fleischer
    • 2
  1. 1.Abteilung Medizinische VirologieUniversität TübingenTübingenFederal Republic of Germany
  2. 2.I Medizinische KlinikUniversität MainzFederal Republic of Germany

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