The Chromosome Cycle

  • Bernard John
  • Kenneth R. Lewis
Part of the Protoplasmatologia book series (PROTOPLASMATOL., volume 6 / B)


The chromosome theory of mendelian heredity had a long and often uneasy development. The heated disputes which were common during the first part of this century arose partly from a lack of understanding between investigators who, though they studied the same phenomena, used different techniques. Lack of communication also contributed to the confusion. Thus, the important cytological contributions of the nineteenth century were performed and presented in ignorance of the crucial experiments of Mendel. Consequently, when McClung and others attempted a consistent synthesis opposition was experienced from both sides.


Polytene Chromosome Nurse Cell Meiotic Prophase Quiescent Centre Maleic Hydrazide 
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  1. Alfert, M., 1958: Variations in cytochemical properties of cell nuclei. Exp. Cell Res. Suppl. 6, 227–235.Google Scholar
  2. Allfrey, V. G., H. Stern, A. E. Mirsky, and H. J. Saetren, 1952: The isolation of cell nuclei in non-aqueous media. J. Gen. Physiol. 35, 529–557.PubMedCrossRefGoogle Scholar
  3. Ammermann, D. von 1965: Cytologische und genetische Untersuchungen an den Ciliaten Stylonychia mytilus Ehrenberg. Arch. Protistenk. 108, 109–152.Google Scholar
  4. Anderson, N. G., 1956: Cell division I. A theoretical approach to the primeval mechanism, the initiation of cell division, and chromosomal condensation. Quart. Rev. Biol. 31, 169–199.PubMedCrossRefGoogle Scholar
  5. Ansley, H. R., 1954: A cytological and cytophotometric study of alternative pathways of meiosis in the house centipede Scutigera forceps (Rafinesque). Chromosoma (Berlin) 6, 656–695.CrossRefGoogle Scholar
  6. Ansley, H. R., 1958: Histones of mitosis and meiosis in Loxa flavicolis (Hemiptera). J. Biophys. Biochem. Cytol. 4, 59–62.PubMedCrossRefGoogle Scholar
  7. Astbury W. T., 1947: X-ray structure of actin. Nature (Lond.) 160, 388–389.CrossRefGoogle Scholar
  8. Avanzi, S., A. Brunori, F. D’Amato, V. N. Roncht, and G. T. S. Mudnozza, 1963: Occurrence of 2 C (G1)and 4 C (G2) nuclei in the radicle meristems of dry seeds in Triticum durum Desf. Its implications in studies of chromosome breakage and on developmental processes. Caryologia 16, 533–558.Google Scholar
  9. Baer D., 1965: Asynchronous replication of DNA in a heterochromatic set of chromosomes in Pseudococcus obscurus. Genetics 52, 275–285.PubMedGoogle Scholar
  10. Bajer A., 1957: Cine-micrographic studies on mitosis in endosperm III. The origin of the mitotic spindle. Exp. Cell Res. 13, 493–502.PubMedCrossRefGoogle Scholar
  11. —1965: Sub-chromatid structure of chromosomes in the living state. Chromosoma (Berlin) 17, 291–302.CrossRefGoogle Scholar
  12. — 1966: Morphological aspects of normal and abnormal mitosis. Pp.90–117 in “Probleme der biologischen Reduplikation”. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  13. Bammi, R. K., and P. Jura 1966: Effects of phenethyl alcohol on chromosomes of Allium cepa. Exp. Cell Res. 41, 124–130.PubMedCrossRefGoogle Scholar
  14. Bastia, D., and M. S. Swaminathan 1967: Ultrastructure of interphase chromosomes. Exp. Cell Res. 48, 18–26.PubMedCrossRefGoogle Scholar
  15. Bauer H., 1932: Die Histologie des Ovars von Tipula paludosa Meig Z. Wiss. Zool. 143, 53–76.Google Scholar
  16. Bayreuther K., 1952: Extra-chromosomale Feulgenpositive Korper (Nucleinkbrper) in the Oogenese der Tipuliden. Naturwissenschaften 39, 71.CrossRefGoogle Scholar
  17. Beermann W., 1952: Chromomerenkonstanz und spezifische Modihkationen der Chromosomenstruktur in der Entwicklung und Organdifferenzierung von Chironomus tentans. Chromosoma (Berlin) 5, 139–198.CrossRefGoogle Scholar
  18. — 1967: Gene action at the level of the chromosome. Pp. 179–201 in “Heritage from Mendel”. Univ. Wisconsin Press.Google Scholar
  19. Berendes, H. D., and H.-G. Keyl 1967: Distribution of DNA in heterochromatin and euchromatin of polytene nuclei of Drosophila hydei. Genetics 57, 1–13.PubMedGoogle Scholar
  20. Bergerard J., 1955: Synthèse de 1’acide thymonucléique au cours du cycle mitotique des neuroblasts et des cellules nerveuses embryonnaires d’un insecte Clitumnus extradentatus Br. (Phasmidae). C. R. Acad. Sci. (Paris) 240, 564–567.Google Scholar
  21. Bier, K., W. Kunz, and D. Ribbert, 1969: Insect oogenesis with and without lamp-brush chromosomes. Pp. 107–115 in “Chromosomes Today”, vol. 2. Edinburgh: Oliver and Boyd.Google Scholar
  22. Bloch D. P., 1962: Histone synthesis in non-replication chromosomes. J. Histochem. Cytochem. 10, 137–144.CrossRefGoogle Scholar
  23. — 1963: The histones: Syntheses, transitions and functions. Pp.205–221 in “The cell in Mitosis”. London: Academic Press.Google Scholar
  24. — and G. C. Godman 1955: A microphotometric study of the syntheses of desoxy-ribonucleic acid and nuclear histone. J. Biophys. Biochem. Cytol. 1, 17–28.PubMedCrossRefGoogle Scholar
  25. — and H. Y. C. Hew 1960: Changes in nuclear histones during fertilization and early embryonic development in the pulmonate snail, Helix aspersa. J. Biophys. Biochem. Cytol. 8, 69–81.PubMedCrossRefGoogle Scholar
  26. — and S. D. Brack 1964: Evidence for the cytoplasmic synthesis of nuclear histone during spermiogenesis in the grasshopper Chortophaga viridi-fasciata (de Geer) J. Cell Biol. 22, 327–340.PubMedCrossRefGoogle Scholar
  27. R. A. MacQuigg, S. D. Brack and J. R. Wu, 1967: The syntheses of deoxyribonucleic acid and histone in the onion root meristem. J. Cell Biol. 33, 451–467.PubMedCrossRefGoogle Scholar
  28. Boivin, A. R., R. Vendrely, et C. Vendrely 1948: L’acide deoxyribonucléique du noyau cellulaire, dépositaire des caractères héréditaires: arguments d’ordre analytique. C. R. Acad. Sci. (Paris) 226, 1061–1063.Google Scholar
  29. Bonner J., 1965: The molecular biology of development. University Press: Oxford.Google Scholar
  30. Bonner, J., R. C. Huang, and R. V. Gilden 1963: Chromosomally directed protein synthesis. Proc. nat. Acad. Sci. U.S. 50, 893–900.CrossRefGoogle Scholar
  31. Brachet J., 1957: Biochemical Cytology. New York: Academic Press.Google Scholar
  32. Branton, D., and F. Rugh 1964: The localization of DNA and ultraviolet absorptive granules in Vicia faba root tips. Exp. Cell Res. 36, 285–296.PubMedCrossRefGoogle Scholar
  33. Breuer, M. E., and C. Pavan 1955: Behaviour of polytene chromosomes of Rhyncosciara angelae at different stages of larval development. Chromosoma (Berlin) 7, 371–386.CrossRefGoogle Scholar
  34. Brinkley, B. R., and E. Stubblefield 1966: The fine structure of the kinetochore of a mammalien cell in vitro. Chromosoma (Berlin) 19, 28–43.CrossRefGoogle Scholar
  35. Brown, D. D., and J. B. Gurdon, 1964: Absence of ribosomal RNA synthesis in the anucleolate mutant of Xenopus laevis. Proc. nat. Acad. Sci. U.S. 51, 139–147.CrossRefGoogle Scholar
  36. Brunish, R., D. Fairley, and J. M. Luck, 1951: Composition of histone prepared from rat liver deoxypentosenucleoprotein. Nature (Lond.) 168, 82–83.CrossRefGoogle Scholar
  37. Bucher, O., 1956: Histologic und mikroskopische Anatomic des Menschen. 2nd. edit. Bern: Verlag Huber.Google Scholar
  38. Bullough, W. S., and E. B. Laurence, 1966: The diurnal cycle in epidermal mitotic division and its relation to chalone and adrenalin. Exp. Cell Res. 43, 343–350.PubMedCrossRefGoogle Scholar
  39. Burton, D. W., 1968: Initial changes in the deoxyribonucleoprotein complexes of kangaroo lymphocytes stimulated with phytobaemagglutinin. Exp. Cell Res. 49, 300–304.PubMedCrossRefGoogle Scholar
  40. Busch, H., W. C. Starbuck, E. J. Singh, and T. S. Ro, 1964: Chromosomal proteins. Pp. 51–71 in “The role of chromosomes in development”. Symp. 23 Soc. Study Dev. and Growth. New York: Academic Press.Google Scholar
  41. Cahn, R. D., and R. Lasher, 1967: Simultaneous synthesis of DNA and specialized cellular products by differentiating cartilage cells in vitro. Proc. nat. Acad. Sci. U.S. 58, 1131–1138.CrossRefGoogle Scholar
  42. Cairns,J., 1963: The bacterial chromosome and its manner of replication as seen by autoradiography. J. molec. Biol. 6, 208–213.PubMedCrossRefGoogle Scholar
  43. Callan, H. G., 1967: The organization of genetic units in chromosomes. J. Cell Sci. 2, 1–7.PubMedGoogle Scholar
  44. Callan, H. G.**— and L. Lloyd, 1960: Lampbrush chromosomes of crested newts Triturus cristatus (Laurenti). Phil. Trans. B702, 135–219.Google Scholar
  45. Camenzind, R., and R. B. Nicklas, 1968: The non-random chromosome segregation in spermatocytes of Gryllotalpa hexadactyla. Chromosoma (Berlin) 24, 324–335.CrossRefGoogle Scholar
  46. Cameron, I. L., and D. M. Prescott, 1963: RNA and protein metabolism in the maturation of the nucleated chicken erythrocyte. Exp. Cell Res. 30, 609–612.PubMedCrossRefGoogle Scholar
  47. Cameron, I. L.**— and D. S. Nachtwey, 1967: DNA synthesis in relation to cell division in Tetrahymena piriformis. Exp. Cell Res. 46, 385–395.PubMedCrossRefGoogle Scholar
  48. Caspersson, T., 1956: Cytochemistry of nuclear elements. Pp.73–103 in “Conference on chromosomes”. Zwolle: Tjeenk-Willink.Google Scholar
  49. Caspersson, T.**— S. Farber, G. E. Foley, J. Kudynowski, E. J. Modest, E. Simonssen, U. Wach, and L. Zech, 1967: Chemical differentiation along metaphase chromosomes. Exp. Cell Res. 49, 219–222.CrossRefGoogle Scholar
  50. Cave, M. D., 1967: Chromosomal 3H-lysine incorporation and patterns of deoxyribonucleic acid synthesis in human cells. Exp. Cell Res. 45, 631–637.PubMedCrossRefGoogle Scholar
  51. Chayen, J., and K. P. Norris, 1953: Cytoplasmic localization of nucleic acids in plant cells. Nature (Lond.) 171, 472–473.CrossRefGoogle Scholar
  52. Chipchase, M. I. H., and M. L. Birnstiel, 1963: On the nature of nucleolar RNA. Proc. nat. Acad. Sci. U.S. 50, 1101–1106.CrossRefGoogle Scholar
  53. Cleffmann, G., 1968: Regulierung der DNS-Menge im Makronucleus von Tetra-hymena. Exp. Cell Res. 50, 1953–207.CrossRefGoogle Scholar
  54. Clowes, F. A. L., 1965: The duration of the G1phase of the mitotic cycle and its relation to radiosensitivity. New Phytol. 64, 355–359.CrossRefGoogle Scholar
  55. Clowes, F. A. L.**— 1968: The DNA content of the quiescent centre and root cap of Zea mays. New Phytol. 67, 631–639.CrossRefGoogle Scholar
  56. Comings, D. E., 1967 a: The duration of replication of the inactive X-chromosome in humans based on the persistence of the heiterochromatic sex chromatin body during DNA synthesis. Cytogenetics 6, 20–37.PubMedCrossRefGoogle Scholar
  57. Comings, D. E.**— 1967 b: Sex chromatin, nuclear size and the cell cycle. Cytogenetics 6 , 120–144.PubMedCrossRefGoogle Scholar
  58. Comings, D. E.**— Crippa, M., 1966: The rate of ribonucleic acid synthesis during the cell cycle. Exp. Cell Res. 42, 371–375.CrossRefGoogle Scholar
  59. Daneholt, B., and J.-E. Edström, 1967: The content of deoxyribonucleic acid in individual polytene chromosome of Chironomus tentans. Cytogenetics 6, 350–356.PubMedCrossRefGoogle Scholar
  60. Darlington, C. D., 1951: Mendel and the determinants. Pp. 315–332 in “Genetics in the 20th Century”. New York: MacMillan.Google Scholar
  61. Darlington, C. D.**— 1958: The Evolution of Genetic Systems. 2nd edit. Edinburgh: Oliver and Boyd.Google Scholar
  62. Darlington, C. D.**— 1969: What we do not know about chromosomes. Pp. 1–4 in “Chromosomes Today”, vol. 2. Edinburgh: Oliver and Boyd.Google Scholar
  63. Darlington, C. D.**— and K. Mather, 1949: The Elements of Genetics. London: Allen and Unwin.Google Scholar
  64. Das, C. C, B. P. Kaufmann, and H. Gay, 1964: Histone-protein transition in Drosophila melanogaster II. Changes during early embryonic development. J. Cell Biol. 23, 423–430.PubMedCrossRefGoogle Scholar
  65. Das, N. K., 1962: Synthetic capacities of chromosome fragments correlated with their ability to maintain nucleolar material. J. Cell Biol. 15, 121–130.PubMedCrossRefGoogle Scholar
  66. Davern, C. I., 1966: Isolation of the DNA of the E. coli chromosome in one piece. Proc. nat. Acad. Sci. U.S. 55, 792–797.CrossRefGoogle Scholar
  67. Davidson, D., 1964: RNA synthesis in roots of Vicia faba. Exp. Cell Res. 35, 317–325.PubMedCrossRefGoogle Scholar
  68. Davidson, D.**— 1966: The onset of mitosis and DNA synthesis in roots of germinating beans. Amer. J. Bot. 53, 491–495.CrossRefGoogle Scholar
  69. Davidson, D.**— and N. G. Anderson, 1961: Chromosome coiling: abnormalities induced by polyamines. Exp. Cell Res. 20, 610–613.CrossRefGoogle Scholar
  70. Davidson, E. H., and A. E. Mirsky, 1965: Gene activity in oogenesis. Pp. 77–97 in “Genetic control of differentiation”. Brookhaven Sympos. Biol. no. 18.Google Scholar
  71. Davidson, E. H.**— M. Crippa, F. R. Kramer, and A. E. Mirsky, 1966: Genomic function during the lampbrush chromosome stage of amphibian oogenesis. Proc. nat. Acad. Sci. U.S. 56, 856–863.CrossRefGoogle Scholar
  72. Dawid, I. B., 1965: Deoxyribonucleic acid in amphibian eggs. J. molec. Biol. 12, 581–599.PubMedCrossRefGoogle Scholar
  73. Dawid, I. B.**— 1966: Evidence for the mitochondral origin of frog egg cytoplasmic DNA. Proc. nat. Acad. Sci. 56, 269–276.PubMedCrossRefGoogle Scholar
  74. Dettlaff, T. A., 1964: Cell divisions, duration of interkinetic states and differentiation in early stages of embryonic development. Advances Morphogenesis 3, 323–360.Google Scholar
  75. Dewey,W. C., and R. M. Humphrey, 1962: Relative radiosensitivity of different phases in the life cycle of L-P 59 mouse fibroblasts and ascites tumour cells. Radiat. Res. 16, 503–530.PubMedCrossRefGoogle Scholar
  76. Dounce,A. L., 1952: The enzymes of isolated nuclei. Exp. Cell Res. Suppl. 2, 103–119.Google Scholar
  77. Dowrick,Y. P. J., 1956: Heterostyly and homostyly in Primula obconica. Heredity (Lond.) 10, 219–236.Google Scholar
  78. Du Praw,E. J., 1965 a: The organization of nuclei and chromosomes in honeybee embryonic cells. Proc. nat. Acad. Sci. U.S. 53, 161–168.CrossRefGoogle Scholar
  79. 1965b: Macromolecular organization of nuclei and chromosomes: a folded fibre model based on whole-mount electron microscopy. Nature (Lond.) 206, 338–343.CrossRefGoogle Scholar
  80. 1966: Evidence for “folded-fibre” organization in human chromosomes. Nature (Lond.) 209, 577–581.CrossRefGoogle Scholar
  81. Duspiva,F., 1966: Enzymatische Aspekte der Mitose. Pp. 120–138 in „Probleme der biologischen Reduplikation“. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  82. Edström,J.-E., 1964: Chromosomal RNA and other nuclear RNA fractions. Pp. 137–152 in “The role of chromosomes in development”. Sympos. 23 Soc. Study Dev. and Growth. New York: Academic Press.Google Scholar
  83. J.-E.andW. Beermann, 1962: The base composition of nucleic acids in chromosomes, puffs, nucleoli and cytoplasm of Chironomus salivary gland cells. J. Cell Biol. 14, 371–380.PubMedCrossRefGoogle Scholar
  84. andJ. G. Gall, 1963: The base composition of ribonucleic acid in lamp-brush chromosomes, nucleoli, nuclear sap and cytoplasm of Triturus oocytes. J. Cell Biol. 19, 279–284.CrossRefGoogle Scholar
  85. Elsdale,T. R.,M. Fischberg, and S. Smith, 1958: A mutation that reduces nucleolar number in Xenopus laevis. Exp. Cell Res. 14, 642–643.PubMedCrossRefGoogle Scholar
  86. Erickson,R. O., 1947: Respiration of developing anthers. Nature (Lond.) 159, 275.CrossRefGoogle Scholar
  87. 1948: Cytological and growth correlations in the flower bud and anther development of Lilium longiflorum. Amer. J. Bot. 35, 729–739.CrossRefGoogle Scholar
  88. Evans,G. M.,andH. Rees, 1966: The pattern of DNA replication at mitosis in the chromosomes of Scilla campanulata. Exp. Cell Res. 44, 150–160.PubMedCrossRefGoogle Scholar
  89. Evans,H. J., 1964: Uptake of 3H-thymidine and patterns of DNA replication in nuclei and chromosomes of Vicia faba. Exp. Cell Res. 35, 381–393.PubMedCrossRefGoogle Scholar
  90. andJ. R. K. Savage, 1963: The relation between DNA synthesis and chromosome structure as resolved by X-ray damage. J. Cell Biol. 18, 525–540.PubMedCrossRefGoogle Scholar
  91. and D. Scott, 1964: Influence of DNA synthesis on the production of chromatid aberrations by X-ray and maleic hydrazide in Vicia faba. Genetics 49, 17–38.PubMedGoogle Scholar
  92. Flamm,W. G.,andM. Birnstiel, 1964: Studies on the metabolism of nuclear proteins. Pp. 230–240 in “The Nucleohistones”. Holden-Day: San Francisco.Google Scholar
  93. Forer,A., 1966: Characterization of the mitotic traction system, and evidence that birefringent spindle fibers neither produce nor transmit force for chromosome movement. Chromosoma (Berlin) 19, 44–98.CrossRefGoogle Scholar
  94. Frenster,J. H., 1965 a: A model of specific de-repression within interphase chromatin. Nature (Lond.) 206, 1269–1270.CrossRefGoogle Scholar
  95. 1965 b: Mechanisms of repression and de-repression within interphase chromatin. Pp. 78–101 in “The chromosome”. Pub. Tissue Culture Assoc. Vol. 1.Google Scholar
  96. V. G. Allfrey,andA. E. Mirsky, 1963: Repressed and active chromatin isolated from interphase lymphocytes. Proc. nat. Acad. Sci. U.S. 50, 1026–1032.CrossRefGoogle Scholar
  97. Gabrusewycz-Garcia,N., 1964: Cytological and autoradiographic studies in Sciara coprophila salivary gland chromosomes. Chromosoma (Berlin) 15, 312–344.CrossRefGoogle Scholar
  98. andR. G. Kleinfeld, 1966: A study of the nucleolar material in Sciara coprophila. J. Cell Biol. 29, 347–359.PubMedCrossRefGoogle Scholar
  99. Gahan,P. B.,J. Chayen,andA. A. Silcox, 1962: Cytoplasmic localization of DNA in Allium cepa. Nature (Lond.) 195, 1115–1116.CrossRefGoogle Scholar
  100. Gall,J. G., 1959: Macronuclear duplication in the ciliated protozoan Euplotes. J. Biophys. Biochem. Cytol. 5, 295–308.PubMedCrossRefGoogle Scholar
  101. 1963 a: Kinetics of deoxyribonuclease action on chromosomes. Nature (Lond.) 198, 36–38.CrossRefGoogle Scholar
  102. 1963 b: Chromosomes and cytodifferentiation. Pp. 119–143 in “Cytodifferentiation and macromolecular synthesis”. Sympos. 21 Soc. Study Dev. and Growth. New York: Academic Press.Google Scholar
  103. 1963 c: Chromosome fibers from an interphase nucleus. Science 139, 120–121.PubMedCrossRefGoogle Scholar
  104. 1966: Chromosome fibers studied by a spreading technique. Chromosoma (Berlin) 20, 221–233.CrossRefGoogle Scholar
  105. 1968: Differential synthesis of the genes for ribosomal RNA during amphibian oogenesis. Proc. nat. Acad. Sci. 2, 553–560.CrossRefGoogle Scholar
  106. andH. G. Callan, 1962: H3-uridine incorporation in lampbrush chromosomes. Proc. nat. Acad. Sci. U.S. 48, 562–570.CrossRefGoogle Scholar
  107. Galton,M.,K. Benirschke,andS. Ohno, 1965: Sex chromosomes of the chinchilla: allocycly and duplication sequence in somatic cells and behaviour in meiosis. Chromosoma (Berlin) 16, 668–680.CrossRefGoogle Scholar
  108. Gassner,G., 1968: Syniaptinemal complexes: recent findings. J. Cell Biol. 35, 166 a (Abst.).Google Scholar
  109. Gimenez-Martin,G.,J. F. Lopez-Saez, and A. Gonzalez-Fernandez, 1963: Somatic chromosome structure (observations with the light microscope). Cytologia (Tokyo) 28, 381–389.CrossRefGoogle Scholar
  110. Gledhill,B. L.,M. P. Gledhill,R. RiglerJr., and N. R. Ringertz, 1966: Changes in deoxyribonucleoprotein during spermiogenesis in the bull. Exp. Cell Res. 41, 652–665.PubMedCrossRefGoogle Scholar
  111. Gorovsky,M. A.,andJ. Woodard, 1967: Histone content of chromosomal loci active and inactive in DNA synthesis. J. Cell Biol. 33, 723–728.PubMedCrossRefGoogle Scholar
  112. Graham,C. F., 1966: The effect of cell size and DNA content in the cellular regulation of DNA synthesis in haploid and diploid embryos. Exp. Cell Res. 43, 13–19.PubMedCrossRefGoogle Scholar
  113. K. Arms, and J. B. Gurdon, 1966: The induction of DNA synthesis by frog egg cytoplasm. Develop. Biol. 14, 349–381.CrossRefGoogle Scholar
  114. — and R. Morgan, 1966: Changes in the cell cycle during early amphibian development. Develop. Biol. 14, 439–460.CrossRefGoogle Scholar
  115. Grasso, J. A., J. W. Woodard, and H. Swift, 1963: Cytochemical studies of nucleic acids and proteins in erythrocyte development. Proc. nat. Acad. Sci. U.S. 50, 134–140.CrossRefGoogle Scholar
  116. Hakansson, A., and A. Levan, 1957: Endo-duplicational meiosis in Allium odorum. Hereditas (Lund) 43, 179–200.CrossRefGoogle Scholar
  117. Hall, C. E., and L. F. Cavalieri, 1961: Four-stranded DNA as determined by electron microscopy. J. Biophys. Biochem. Cytol. 10, 347–351.PubMedCrossRefGoogle Scholar
  118. Harris, H., 1965: The short-lived RNA in the cell nucleus and its possible role in evolution. Pp.469–477 in “Evolving genes and proteins”. New York: Academic Press.Google Scholar
  119. — 1966: Hybrid cells from mouse and man: a study in genetic regulation. Proc. Roy. Soc. (Lond.) B 166, 358–368.CrossRefGoogle Scholar
  120. Hayashi, M., M. N. Hayashi, and S. Spiegelman, 1964: DNA circularity and the mechanism of strand selection in the generation of genetic messages. Proc. nat. Acad. Sci. U.S. 51, 351–359.CrossRefGoogle Scholar
  121. Hayter, A. M., and R. Riley, 1969: The significance of DNA: histone ratios in meiotic synapsis. Pg. 266 in “Chromosomes Today”, vol.2. Edinburgh: Oliver and Boyd.Google Scholar
  122. Heddle, J. A., and J. E. Trosko, 1966: Is the transition from chromosome to chromatid aberrations the result of the formation of single-stranded DNA? Exp. Cell Res. 42, 171–177.PubMedCrossRefGoogle Scholar
  123. Henderson, S. A., 1964: RNA synthesis during male meiosis and spermiogenesis. Chromosoma (Berlin) 15, 345–366.CrossRefGoogle Scholar
  124. Hennig, W., 1967: Untersuchungen zur Struktur und Funktion des Lampenbürsten-Y-Chromosoms und der Spermatogenese von Drosophila. Chromosoma (Berlin) 22, 294–357.CrossRefGoogle Scholar
  125. Hess, C., 1967 a: Complementation of genetic activity in translocated fragments of the Y-chromosome in Drosophila hydei. Genetics 56, 283–295.PubMedGoogle Scholar
  126. Hess, C., 1967 b: Morphologische Variabilitat der chromosomalen Funktionsstrukturen und der Spermatocytenkerne von Drosophila-Aiten. Chromosoma (Berlin) 21, 429–445.CrossRefGoogle Scholar
  127. Hotta, Y., and H. Stern, 1963 a: Synthesis of messenger-like ribonucleic acid and protein during meiosis in isolated cells of Trillium erectum.J. Cell Biol. 19, 45–58.PubMedCrossRefGoogle Scholar
  128. — — 1963 b: Molecular facets of mitotic regulation I. Synthesis of thymidine kinase. Proc. nat. Acad. Sci. U.S. 49, 648–654.CrossRefGoogle Scholar
  129. — 1965: Polymerase and kinase activities in relation to RNA synthesis during meiosis. Protoplasma 60, 218–232.PubMedCrossRefGoogle Scholar
  130. — and A. Bassel, 1965: Molecular size and circularity of DNA in cells of mammals and higher plants. Proc. nat. Acad. Sci. U.S. 53, 357–362.CrossRefGoogle Scholar
  131. M. Ito, and H. Stern, 1966: Synthesis of DNA during meiosis. Proc. nat. Acad. Sci. U.S. 56, 1184–1191.CrossRefGoogle Scholar
  132. L. G. Parchman, and H. Stern, 1968: Protein synthesis during meiosis. Proc. nat. Acad. Sci. 60, 575–582.CrossRefGoogle Scholar
  133. Howard, A., and S. R. Pelc, 1953: Synthesis of deoxyribonucleic acid in normal and irradiated cells and its relation to chromosome breakage. Heredity (Lond.), Suppl. 6, 261–274.Google Scholar
  134. Hsu, T. C., W. C. Dewey, and R. M. Humphrey, 1962: Radiosensitivity of the cells of Chinese hamster in vitro in relation to the cell cycle. Exp. Cell Res. 27, 441–452.PubMedCrossRefGoogle Scholar
  135. Huang, C. C., and J. Bonner, 1965: Histone-bound RNA, a component of native nucleohistone. Proc. nat. Acad. Sci. U.S. 54, 960–967.CrossRefGoogle Scholar
  136. Huang, C. C., J. Bonner, and K. Murray, 1964: Physical and Biological properties of nucleohistones. J. molec. Biol. 8, 54–64.PubMedCrossRefGoogle Scholar
  137. Huberman, J. A., and J. G. Attardi, 1966: Isolation of metaphase chromosomes from HeLa cells. J. Cell Biol. 31, 95–105.PubMedCrossRefGoogle Scholar
  138. — and A. D. Riggs, 1966: Autoradiography of chromosomal DNA fibers from Chinese hamster cells. Prot. nat. Acad. Sci. U.S. 55, 599–606.CrossRefGoogle Scholar
  139. Hughes-Schrader, S., 1940: The meiotic chromosomes of the male Llaveiella tacnechina Morrison (Coccidae) and the question of the tertiary split. Biol. Bull. 78, 312–337.CrossRefGoogle Scholar
  140. Ito, M., Y. Hotta, and H. Stern, 1967: Studies of meiosis in vitro II. Effect of inhibiting DNA synthesis during meiotic prophase on chromosome structure and behaviour. Develop. Biol. 6, 54–77.CrossRefGoogle Scholar
  141. Izawa, M., Y. G. Allfrey, and A. E. Mirsky, 1963 a: The relationship between RNA synthesis and loop structure in lampbrush chromosomes. Proc. nat. Acad. Sci. U.S. 49, 544–561.CrossRefGoogle Scholar
  142. — — — 1963 b: Composition of the nucleus and chromosomes in the lampbrush stage of the newt oocyte. Proc. nat. Acad. Sci. U.S. 50, 811–817.CrossRefGoogle Scholar
  143. John, B., and K. R. Lewis, 1965: The meiotic system. Protoplasmatologia VI F 1. Wien: Springer-Verlag.Google Scholar
  144. — — 1968: The Chromosome Complement. Protoplasmatologia VI A. Wien: Springer-Verlag.CrossRefGoogle Scholar
  145. Jokelainen, P. T., 1967: The ultrastructure and spatial organization of the metaphase kinetochore in mitotic rat cells. J. Ultrastruct. Res. 19, 19–44.PubMedCrossRefGoogle Scholar
  146. Jona, R., 1966: La durata del ciclo mitotico nella Bellavalia romana determinata per via autoradiografica mediante l’imprego della timidina H3. Caryologia 19, 429–442.Google Scholar
  147. Jones, K. W., 1965: The role of the nucleolus in the formation of ribosomes. J. Ultrastruct. Res. 13, 257–262.PubMedCrossRefGoogle Scholar
  148. Kemp, C. L., 1964: The effect of inhibitors on RNA and protein synthesis on cytological development during meiosis. Chromosoma (Berlin) 15, 652–665.CrossRefGoogle Scholar
  149. Keyl, H.-G., 1965: Duplikationen von Untereinheiten der chromosomalen DNS während der Evolution von Chironomus thummi. Chromosoma (Berlin) 17, 139–180.CrossRefGoogle Scholar
  150. — 1966: Increase of DNA in chromosomes. Pp. 99–101 in “Chromosomes Today”, vol. 1. Edinburgh: Oliver and Boyd.Google Scholar
  151. — und C. Pelling, 1963: Differentielle DNS-Replikation in den Speicheldrüsen von Chironomus thummi. Chromosoma (Berlin) 14, 347–359.CrossRefGoogle Scholar
  152. Kihlman, B. A., 1967: Actions of chemicals on dividing cells. New Jersey: Prentice Hall.Google Scholar
  153. Killander, D., and A. Zetterberg, 1965: A quantitative cytochemical investigation of the relationship between cell mass and initiation of DNA synthesis in mouse fibroblasts in vitro. Exp. Cell Res. 40, 12–20.PubMedCrossRefGoogle Scholar
  154. Kleinschmidt, A. und R. K. Zahn, 1959: Über Desoxyribonucleinsäure-Molekeln in Protein-Mischfilmen. Z. Naturforschg. 14 b, 770–779.Google Scholar
  155. Kluss, B. C, 1962: Electron microscopy of the macronucleus of Euplotes eurystomus. J. Cell Biol. 13, 462–465.PubMedCrossRefGoogle Scholar
  156. Konrad, C. R., 1963: Protein synthesis and RNA synthesis during mitosis in animal cells. J. Cell Biol. 19, 267–277.PubMedCrossRefGoogle Scholar
  157. Kusanagi, A., 1964 a: Cytological studies on Luzula chromosome VI. Migration of the nucleolar RNA to metaphasic chromosomes and spindle. Bot. Mag. Tokyo 77, 388–392.Google Scholar
  158. — 1964 b: RNA synthetic activity in the mitotic nuclei. Jap. J. Genet. 39, 254–258.Google Scholar
  159. Kuwada, Y., N. Shinke, and G. Oura, 1938: Artificial uncoiling of the chromosome spirals as a method of investigation of the chromosome structure. Z. Wiss. Mikr. 55 , 8–16.Google Scholar
  160. LaCour, L. F., 1963: Ribose nucleic acid and the metaphase chromosome. Exp. Cell Res. 29, 112–118.PubMedCrossRefGoogle Scholar
  161. — and J. Chayen, 1958: A cyclic staining behaviour of the chromosomes during mitosis and meiosis. Exp. Cell Res. 14, 402–468.CrossRefGoogle Scholar
  162. LaCour, L. F., and S. R. Pelc, 1958: Effect of colchicine on the utilization of labelled thymidine during chromosomal reproduction. Nature (Land.) 182, 506–508.CrossRefGoogle Scholar
  163. — — 1959: Effect of colchicine on the utilization of thymidine labelled with tritium during chromosomal reproduction. Nature (Lond.) 183, 1455–1456.CrossRefGoogle Scholar
  164. — and B. Wells, 1967: The loops and ultrastructure of the nucleolus in Ipheion uniflorum. Z. Zellforsch. 82, 25–45.CrossRefGoogle Scholar
  165. Leach, W. M., 1964: Retention of tritiated thymidine in grasshopper neuroblasts. Exp. Cell Res. 35, 201–204.PubMedCrossRefGoogle Scholar
  166. Leslie, L, 1961: Biochemistry of heredity: a general hypothesis. Nature (Lond.) 189, 260–268.CrossRefGoogle Scholar
  167. Lewis, K. R., and B. John, 1963: Chromosome Marker. London: Churchill.Google Scholar
  168. — — 1968: The chromosomal basis of sex determination. Int. Rev. Cytol. 23, 277–379.PubMedCrossRefGoogle Scholar
  169. Lezzi, M., 1965: Die Wirkung von DNase auf isolierte Polytan-Chromosomen. Exp. Cell Res. 39, 289–292.PubMedCrossRefGoogle Scholar
  170. — 1967: Cytochemische Untersuchungen an Puffs isolierter Speicheldrüsen-Chromosomen von Chironomus. Chromosoma (Berlin) 21, 89–108.CrossRefGoogle Scholar
  171. Liao, S., and A. H. Lin, 1967: Prostatic nuclear chromatin: an effect of testosterone on the synthesis of ribonucleic acid rich in cytidyl (3′ 5′) guanosine. Proc. nat. Acad. Sci. U.S. 57, 379–386.CrossRefGoogle Scholar
  172. Liau, M. C, L. S. Hnilica, and R. B. Hurlbert, 1965: Regulation of RNA synthesis in isolated nucleoli by histones and nuclear proteins. Proc. nat. Acad. Sci. U.S. 53, 626–633.CrossRefGoogle Scholar
  173. Lima-de-Faria, A., 1959: Differential uptake of tritiated thymidine into hetero— and euchromatin in Melanoplus and Secale. J. Biophys. Biochem. Cytol. 6, 457–466.PubMedCrossRefGoogle Scholar
  174. — 1962 a: Metabolic DNA in Tipula oleracea. Chromosoma (Berlin) 13, 47–59.Google Scholar
  175. — 1962b: Progress in tritium autoradiography. Progr. Biophys. 12, 282–317.Google Scholar
  176. — and M. J. Moses, 1966: Ultrastructure and cytochemistry of metabolic DNA in Tipula. J. Cell Biol. 30, 177–192.PubMedCrossRefGoogle Scholar
  177. Lima-de-Faria, A., B. Nilsson, D. Cove, A. Puga, and H. Jaworska, 1968: Tritium labelling and cytochemistry of extra DNA in Acheta. Chromosoma 25, 1–20.PubMedCrossRefGoogle Scholar
  178. Lin, H. J., J. D. Karkas, and E. C. Chargaff, 1966: Template functions in the enzymic formation of polyribonucleotides II. Metaphase chromosomes as templates in the enzymic synthesis of ribonucleic acid. Proc. nat. Acad. Sci. U.S. 56, 954–959.CrossRefGoogle Scholar
  179. Lindsley, D. L., and E. Novitski, 1958: Localization of the genetic factors responsible for the kinetic activity of X-chromosomes of Drosophila melanogaster. Genetics 43, 790–798.PubMedGoogle Scholar
  180. Linskens, H. F., 1966: Die Änderung des Protein- und Enzym-Musters während der Pollenmeiose und Pollenentwicklung. Physiologische Untersuchungen zur Reifeteilung. Planta (Berlin) 69, 79–91.CrossRefGoogle Scholar
  181. Littau, V. C, C. J. Burdick, V. G. Allfrey, and A. E. Mirsky, 1965: The role of histones in the maintenance of chromatin structure. Proc. nat. Acad. Sci. U.S. 54, 1204–1212.CrossRefGoogle Scholar
  182. MacGregor, H. C., 1965: The role of lampbrush chromosomes in the formation of nucleoli in amphibian oocytes. Quart. J. micr. Sci. 106, 215–228.Google Scholar
  183. — 1967: Pattern of incorporation of [3H] uridine into RNA of amphibian oocyte nucleoli. J. Cell Sci. 2, 145–150.PubMedGoogle Scholar
  184. — and H. G. Callan, 1962: The actions of enzymes on lampbrush chromosomes. Quart. J. micr. Sci. 103, 173–203.Google Scholar
  185. Maio, J. J., and C. L, Schildkraut, 1966: Isolation and properties of mammalian metaphase chromosomes. Fed. Proc. 25, 707 (Abst.).Google Scholar
  186. Marmur, J., and P. Doty, 1961: Terminal renaturation of DNA. J. molec. Biol. 3, 585–594.PubMedCrossRefGoogle Scholar
  187. Marshak, A., and C. Marshak, 1955: Quantitative determination of desoxyribonucleic acid in echinoderm germ cells. Exp. Cell Res. 8, 126–146.PubMedCrossRefGoogle Scholar
  188. Martin, P. G., 1966: Variation in the amounts of nucleic acid in the cells of different species of higher plants. Exp. Cell Res. 27, 84–94.CrossRefGoogle Scholar
  189. Matsuura, H., and M. Iwabuchi, 1962: Effect of inorganic salts on cell division II. Production of meiotic abnormalities in PMCs of Paris by NaCl, KC1 and CaCl2. J. Fac. Sci. Hokkaido Univ. V 8, 115–142.Google Scholar
  190. Maul, G. C, and T. H. Hamilton, 1967: The intranuclear localization of two DNA-dependent RNA polymerase activities. Proc. nat. Acad. Sci. U.S. 57, 1371–1378.CrossRefGoogle Scholar
  191. Mazia, D., 1961: Mitosis and the physiology of cell division. Pp. 77–412 in “The Cell”, vol.3. New York: Academic Press.Google Scholar
  192. — and R. T. Hinegardner, 1963: Enzymes of DNA synthesis in nuclei of sea urchinembryos. Proc. nat. Acad. Sci. U.S. 50, 148–156.CrossRefGoogle Scholar
  193. McCarthy, B. J., and B. H. Hoyer, 1964: Identity of DNA and diversity of messenger RNA molecules in normal mouse tissues. Proc. nat. Acad. Sci. U.S. 52, 915–922.CrossRefGoogle Scholar
  194. McGrath, R. A., R. W. Williams, 1967: Interruptions in single strands of the DNA in slime mould and other organisms. Biophys. J. 7, 309–317.PubMedCrossRefGoogle Scholar
  195. Meyer, G. F., 1960: The fine structure of spermatocyte nuclei of Drosophila melanogaster. Proc. Europ. Reg. Congr. Electron Microscopy.Google Scholar
  196. Meyer, G. F., 1963: Die Funktionsstrukturen des Y-Chromosoms in den Spermatocytenkernen von Drosophila hydei, D. neohydei, D. repleta und einigen anderen Drosophila-Arten. Chromosoma (Berlin) 14, 207–255.CrossRefGoogle Scholar
  197. Miller, O. L., 1965: Fine structure of lampbrush chromosomes. Pp. 79–97 in “Genes and chromosomes: structure and function”. Nat. Cancer Inst. Monogr. 18.Google Scholar
  198. Mirsky, A. E., and H. Ris, 1949: Variable and constant components of chromosomes. Nature (Lond.) 163, 666–667.CrossRefGoogle Scholar
  199. Mirsky, A. E., and S. Osawa, 1961: The interphase nucleus. Pp. 677–770 in “The Cell”, vol.2. New York: Academic Press.Google Scholar
  200. Molè-Bajer, J., 1965: Telophase segregation of Chromosomes and amitosis. J. Cell Biol. 25, 79–94.PubMedCrossRefGoogle Scholar
  201. Monesi, V., 1965 a: Differential rate of ribonucleic acid synthesis in the autosomes and sex chromosomes during male meiosis in the mouse. Chromosoma (Berlin) 17, 11–21.Google Scholar
  202. Monesi, V., 1965 b: Synthetic activities during spermatogenesis in the mouse. Exp. Cell Res. 39, 197–224.PubMedCrossRefGoogle Scholar
  203. M. Crippa, and R. Zito-Bignami, 1967: The stage of chromosome duplication in the cell cycle as revealed by X-ray breakage and 3H-thymidine labelling. Chromosoma (Berlin) 21, 369–386.CrossRefGoogle Scholar
  204. Moses, M. J., and J. H. Taylor, 1955: Desoxypentose nucleic acid synthesis during microgametogenesis in Tradescantia. Exp. Cell Res. 9, 474–488.PubMedCrossRefGoogle Scholar
  205. Needham, J., and D. M. Needham, 1930: On phosphorus metabolism in embryonic life. I. Invertebrate eggs. J. Exp. Biol. 7, 317–348.Google Scholar
  206. Niehaus, W. G., and C. P. Barnum, 1965: Incorporation of radioisotope in vivo into ribonucleic acid and his tone in a fraction of nuclei preparing for mitosis. Exp. Cell Res. 39, 435–442.PubMedCrossRefGoogle Scholar
  207. Nilsson, B., 1966: DNA bodies in the germ line of Achaeta domesticus (Orthoptera). Hereditas (Lund) 56, 396–398.CrossRefGoogle Scholar
  208. Nur, U., 1966: Non-replication of heterochromatic chromosomes in a mealy bug, Planococcus citri (Coccoidea: Homoptera). Chromosoma (Berlin) 19, 439–448.CrossRefGoogle Scholar
  209. Ohno, S., 1967: Sex Chromosomes and Sex Linked Genes. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  210. Ohno, S., W. Beçak, and M. L. Beçak, 1964: X-autosome ratio and the behaviour pattern of individual X-chromosomes in placental mammals. Chromosma (Berlin) 15, 14–30.CrossRefGoogle Scholar
  211. Okazaki, K., and H. Holtzer, 1966: Myogenesis: fusion, myosin synthesis and the mitotic cycle. Proc. nat. Acad. Sci. U.S. 56, 1484–1490.CrossRefGoogle Scholar
  212. Östergren, G., J. Molè-Bajer, and A. Bajer, 1960: An interpretation of transport phenomena at mitosis. Ann. N.Y. Acad. Sci. 90, 381–408.PubMedCrossRefGoogle Scholar
  213. Östergren, G., J. Molè-Bajer, A. Bajer and K. Östergren, 1966: Mitosis with undivided Chromosomes III. Inhibition of chromosome reproduction in Tradescantia by specific mutations. Pp. 128–130 in “Chromosomes To-day”, vol. 1, Edinburgh: Oliver and Boyd.Google Scholar
  214. Painter, T. S., 1966: The role of the E-chromosomes in Cecidomyidae. Proc. nat. Acad. Sci. U.S. 56, 853–855.CrossRefGoogle Scholar
  215. Painter, T. S., and J. J. Biesele, 1966: The fine structure of the hypopharyngeal gland cell of the honey bee during development and secretion. Proc. nat. Acad. Sci. U.S. 55, 1414–1419.CrossRefGoogle Scholar
  216. Pappas, G. D., 1956: Helical structures in the nucleus of Amoeba proteus. J. Biophys. Biochem. Cytol. 2 (Suppl.), 431–434.PubMedCrossRefGoogle Scholar
  217. Pappas, G. D., and P. W. Brandt, 1958: Helical structures in the nuclei of free-living amoebas. Proc. 4th Int. Conf. Elect. Micr. Berlin 2, 244–246.Google Scholar
  218. Peacock, W. J., 1965: Chromosome replication. Pp. 101–123 in “Genes and chromosomes: structure and function”. Nat. Cancer Inst. Monogr. 18.Google Scholar
  219. Pelc, S. R., 1964: Labelling of DNA and cell division in so-called non-dividing tissues. J. Cell Biol. 22, 21–28.PubMedCrossRefGoogle Scholar
  220. Pelling, C, 1964: Ribonukleinsaure-Synthese der Riesenchromosomen. Autoradiographische Untersuchungen an Chironomus tentans. Chromosoma (Berlin) 15, 71–122.CrossRefGoogle Scholar
  221. Pelling, C, 1966: A replicative and synthetic chromosomal unit—the modern concept of the chromomere. Proc. roy. Soc. (Lond.) B 164, 279–289.CrossRefGoogle Scholar
  222. Perkowska, E., H. C. MacGregor, and M. L. Birnstiel, 1968: Gene amplification in the oocyte nucleus of mutant and wild type Xenopus laevis. Nature 217, 649–650.PubMedCrossRefGoogle Scholar
  223. Perry, R. P., 1965: The nucleolus and the synthesis of ribosomes. Pp.325–339 in “Genes and Chromosomes: structure and function”. Nat. Cancer Inst. Monogr. 18.Google Scholar
  224. Perry, R. P., and M. Errera, 1960: The influence of nucleolar ribonucleic acid metabolism on that of the nucleus and cytoplasm. Pp.24–29 in “The Cell Nucleus”. London: Butterworth.Google Scholar
  225. Perry, R. P., A. Hell, and M. Errera, 1961: The role of the nucleolus in ribonucleic and protein synthesis. I. Incorporation of cytidine into normal and inactivated HeLa cells. Biochim. Biophys. Acta 49, 47–57.PubMedCrossRefGoogle Scholar
  226. Pollister, A. W., 1952: Nucleoproteins of the nucleus. Exp. Cell Res. 2 (Suppl.), 59–70.Google Scholar
  227. Plaut, W., D. Nash, and T. Fanning, 1966: Ordered replication of DNA in polytene chromosomes of Drosophila melanogaster. J. molec. Biol. 16, 85–93.PubMedCrossRefGoogle Scholar
  228. Prensky, W., and H. H. Smith, 1964: Incorporation of 3H-arginine in chromosomes of Vicia faba. Exp. Cell Res. 34, 525–532.PubMedCrossRefGoogle Scholar
  229. Prescott, D., 1963: RNA and protein replacement in the nucleus during growth and division in the conservation of components in the chromosome. Pp. 111–128 in “Cell Growth and Cell Division”. New York: Academic Press.Google Scholar
  230. — 1964: The normal cell’cycle. Pp. 71–97, Chapt. 3, in “Synchrony in Cell Division and Growth”. Interscience Pub., New York.Google Scholar
  231. — 1966: The synthesis of total macronuclear protein, histone and DNA during the cell cycle in Euplotes eurystomus. J. Cell Biol. 31, 1–9.PubMedCrossRefGoogle Scholar
  232. Prescott, D., and M. A. Bender, 1963: Autoradiographic study of chromatid distribution of labelled DNA in two types of mammalian cells in vitro. Exp. Cell Res. 29, 430–442.PubMedCrossRefGoogle Scholar
  233. Ptashne, M., 1960: The behaviour of strong and weak centromeres at second anaphase of Drosophila melanogaster. Genetics 45, 499–506.PubMedGoogle Scholar
  234. Quastler, H., 1965: The analysis of cell population kinetics. Pp. 18–36 in “Cell Proliferation”. Oxford: Blackwell.Google Scholar
  235. Rao, M. Y. N., and D. M. Prescott, 1967: Micronuclear RNA synthesis in Paramoecium caudatum. J. Cell Biol. 33, 281–285.CrossRefGoogle Scholar
  236. Rasch, E., and J. W. Woodard, 1959: Basic proteins of plant nuclei during normal and pathological growth. J. Biophys. Biochem. Cytol. 6, 263–276.PubMedCrossRefGoogle Scholar
  237. Rees, H., and G. M. Evans, 1966: A correlation between the localization of chiasmata and the replication pattern of chromosomal DNA. Exp. Cell Res. 44, 161–164.PubMedCrossRefGoogle Scholar
  238. Reid, B. R., and R. D. Cole, 1964: Biosynthesis of a lysine-rich histone in isolated calf thymus nuclei. Proc. mat. Acad. Sci. U.S. 51, 1044–1050.CrossRefGoogle Scholar
  239. Rinehart, K., 1966: Maize DNA composition: analysis of plants with and without B chromosomes. Maize Genet. Coop. News Letter 40, 56–58.Google Scholar
  240. Ringertz, N. R., J. L. E. Ericson, and O. Nilsson, 1967: Macronuclear chromatin structure in Euplotes. Exp. Cell Res. 48, 97–117.PubMedCrossRefGoogle Scholar
  241. Ris H., 1961: Ultrastructure and molecular organization of genetic systems. Canad. J. Genet. Cytol. 3, 95–120.PubMedGoogle Scholar
  242. — 1966 a: Fine structure of chromosomes. Proc. roy. Soc. (Lond.) B 164, 256–257.Google Scholar
  243. — 1966b: The organization of chromosomal nucleohistone fibrils. Pp.339–340 in “Electron Microscopy”. Tokyo: Maruzen Co.Google Scholar
  244. — 1967: Ultrastructure of the animal chromosome. Pp. 11–21 in “Regulation of nucleic acid and protein biosynthesis”. Elsevier Pub. Co: Amsterdam.Google Scholar
  245. — 1968: Effect of fixation on the dimension of nucleohistone fibers. Amer. Soc. Cell Biol. (Abst.).Google Scholar
  246. Ritossa, F. M., and S. Spiegelmann, 1965: Localization of DNA complementary to ribosomal RNA in the nucleolus organizer region of Drosophila melanogaster. Proc. nat. Acad. Sci. U.S. 53, 737–745.CrossRefGoogle Scholar
  247. Robbins, E., and T. W. Borun, 1967: The cytoplasmic synthesis of histones in HeLa cells and its temporal relationship to DNA replication. Proc. nat. Acad. Sci. U.S. 57, 409–416.CrossRefGoogle Scholar
  248. Rodman, T. C., 1967: DNA replication in salivary gland nuclei of Drosophila melanogaster at successive larval and prepupal stages. Genetics 55, 375–386.PubMedGoogle Scholar
  249. Roth, T. F., 1966: Changes in the synaptinemal complex during meiotic prophase in mosquitoe oocytes. Protoplasma 61, 346–386.CrossRefGoogle Scholar
  250. Roth— and M. Pro, 1967: DNA-dependent formation of the synaptinemal complex at meiotic prophase. J. Cell Biol. 35, 247–255.PubMedCrossRefGoogle Scholar
  251. — and L. G. Parchman, 1968: Diplotene achiasmatic chromosomes following normal synapsis at pachynema. 25th Ann. EMS A Meeting (Abst.).Google Scholar
  252. Rudkin, G. T., 1963: The structure and function of heterochromatin. Proc. 11th Int. Congr. Genetics 2, 359–374.Google Scholar
  253. — 1965 a: Nonreplicating DNA in giant chromosomes. Genetics 552, 470 (Abst.).Google Scholar
  254. — 1965 b: The relative mutabilities of DNA in regions of the X chromosomes of Drosophila melanogaster. Genetics 52, 665–681.PubMedGoogle Scholar
  255. — and S. L. Corlette, 1957: Disproportionate synthesis of DNA in a polytene chromosome region. Proc. nat. Acad. Sci. U.S. 43, 964–968.CrossRefGoogle Scholar
  256. Sachsenmaier, W., 1966: Analyse des Zellcyklus durch Eingriffe in die Makro-molekül-Biosynthese. Pp. 139–159 in „Probleme der biologischen Reduplikation“. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  257. Saint-Amand, G. S., N. G. Anderson, and M. E. Gaulden, 1955: Quoted in “Mito-genesis”. Dev. Biol. Conference Series (1956). Univ. Chicago Press 1959.Google Scholar
  258. Sampson, M., A. Katoh, Y. Hotta, and H. Stern, 1963: Metabolically labile deoxyribonucleic acid. Proc. nat. Acad. Sci. U.S. 50, 459–463.CrossRefGoogle Scholar
  259. Schaik, N. van, and M. J. Pitout, 1966: DNA from maize with B chromosomes. Maize Genet. Coop. News Letter 40, 123–125.Google Scholar
  260. — — and A. W. H. Neitz, 1967: Base ratios of maize DNA. Maize Genet. Coop. News Letter 41, 167–168.Google Scholar
  261. Schultz, J., 1965: Genes, differentiation and animal development. Pp. 116–147 in “Genetic Control of Differentiation”. Brookhaven Symp. Biol. no. 18.Google Scholar
  262. Scott, D., and H. J. Evans. 1964: Influence of the nucleolus on DNA synthesis and mitosis in Vicia faba. Exp. Cell Res. 36, 145–159.PubMedCrossRefGoogle Scholar
  263. Serra, J. A., 1947: The parallelism between the chemical and the morphological changes in the chromosomes during mitosis and meiosis. Exp. Cell Res. 1 (Suppl.), 111–122.Google Scholar
  264. — 1955: Chemistry of the nucleus. Pp. 1–54 in “Encyclopaedia of Plant Physiology”. Berlin: Springer-Verlag.Google Scholar
  265. Shapiro, I. M., and L. H. Levina, 1967: Autoradiographical study on the time of nuclear protein synthesis in human leucocyte blood culture. Exp. Cell Res. 47, 75–85.PubMedCrossRefGoogle Scholar
  266. Sheridan, W. F., and H. Stern, 1967: Histones of meiosis. Exp. Cell Res. 45, 323–335.PubMedCrossRefGoogle Scholar
  267. Skinner, D. M., 1967: Satellite DNA’s in the crabs Gecarcinus lateralis and Cancer pagurus. Proc. nat. Acad. Sci. U.S. 58, 103–110.CrossRefGoogle Scholar
  268. Solari, J., 1965: Structure of the chromatin in the sea urchin sperm. Proc. nat. Acad. Sci. U.S. 53, 503–511.CrossRefGoogle Scholar
  269. Sotelo, J. R., and O. Trujillo-Cenoz, 1960: Electron microscope study of spermatogenesis. Z. Zellforsch. 51, 243–277.PubMedGoogle Scholar
  270. Sparvoli, E., H. Gay, and B. P. Kaufmann, 1966: Duration of the mitotic cycle in Haplopappus gracilis. Caryologia 19, 65–71.Google Scholar
  271. Steffensen, D. M., 1953: Induction of chromosome breakage at meiosis by a magnesium deficiency in Tradescantia. Proc. nat. Acad. Sci. U.S. 39, 613–620.CrossRefGoogle Scholar
  272. — 1955: Chromosome breakage with a calcium deficiency in Tradescantia. Proc. nat. Acad. Sci. U.S. 41, 155–160.CrossRefGoogle Scholar
  273. — 1966: Synthesis of ribosomal RNA during growth and division in Lilium. Exp. Cell Res. 44, 1–12.PubMedCrossRefGoogle Scholar
  274. Stein, O., and H. Quastler, 1963: The use of tritiated thymidine in the study of tissue activation during germination in Tea mays. Amer. J. Bot. 50, 1006–1011.CrossRefGoogle Scholar
  275. Stern, H., and A. E. Mirsky, 1953: Soluble enzymes of nuclei isolated in sucrose and non-aqueous media. J. gen. Physiol. 37, 177–187.PubMedCrossRefGoogle Scholar
  276. Stern, H., and Y. Hotta, 1963: Regulated synthesis of RNA and protein in the control of cell division. Pp. 59–70 in “Meristems and Differentiation”. Brookhaven Symp. Biol. 16.Google Scholar
  277. — — 1967: Chromosome behaviour during development of meiotic tissue. Pp.47–76 in “The Control of Nuclear Activity”. New Jersey: Prentice Hall.Google Scholar
  278. Stevens, A. R., 1967: Machinery for exchange across the nuclear envelope. Pp. 189–271 in “The Control of Nuclear Activity”. Symp. Soc. Gen. Physiol. New Jersey: Prentice Hall.Google Scholar
  279. Stewart, J. E., and J. Papaconstantinou, 1967: A stabilization of RNA templates in lens cell differentiation. Proc. nat. Acad. Sci. U.S. 58, 95–102.CrossRefGoogle Scholar
  280. Stockdale, F. E., and H. Holtzer, 1961: DNA synthesis and myogenesis. Exp. Cell Res. 24, 508–520.PubMedCrossRefGoogle Scholar
  281. Stubblefield, E., 1964: DNA synthesis and chromosomal morphology of Chinese hamster cells cultured in media containing N-deacetyl-N-methyl colchicines (colcemid). Pp. 223–248 in “Symp. Inter. Soc. Cell Biol”, vol. 3. New York: Academic Press.Google Scholar
  282. Swanson, C. P., and W. J. Young, 1965: Chromosome reproduction in mitosis and meiosis. Pp. 107–129 in “Reproduction: Molecular, Subcellular and Cellular”. 24th Sympos. Soc. Dev. Biol. New York: Academic Press.Google Scholar
  283. Swift, H., 1962: Nucleic acids and cell morphology in dipteran salivary gland cells. Pp. 73–125 in “The Molecular Control of Cellular Activity”. London: McGraw Hill.Google Scholar
  284. Tanaka, R., 1965: H3-thymidine autoradiographic studies on the heteropycnosis, heterochromatin and euchromatin in Spiranthes sinensis, Bot. Mag. Tokyo 78, 50–62.Google Scholar
  285. Taylor, E. W., 1965: Control of DNA synthesis in mammalian cells in culture. Exp. Cell Res. 40, 316–322.PubMedCrossRefGoogle Scholar
  286. Taylor, J. H., 1957: The time and mode of duplication of chromosomes. Amer. Nat. 91, 209–221.CrossRefGoogle Scholar
  287. — 1958 a: The mode of chromosome duplication in Crepis capillaris. Exp. Cell Res. 15, 350–357.PubMedCrossRefGoogle Scholar
  288. — 1958 b: Sister chromatid exchanges in tritium labelled chromosomes. Genetics 43, 515–529.PubMedGoogle Scholar
  289. — 1959: Autoradiographic studies of nucleic acids and proteins during meiosis in Lilium longiflorum. Amer. J. Bot. 46, 477–484.CrossRefGoogle Scholar
  290. Taylor, J. H., 1960: A synchronous duplication of chromosomes in cultured cells of Chinese hamster. J. Biophys. Biochem. Cytol. 7. 455–464PubMedCrossRefGoogle Scholar
  291. — 1963: The replication and organization of DNA in chromosomes. Pp. 65–111 in “Molecular Genetics”. Part. 1. New York: Academic Press.Google Scholar
  292. — 1965: The distribution of tritium labelled DNA among chromosomes during meiosis I. Spermatogenesis in the grasshopper. J. Cell Biol. 25, 57–67.PubMedCrossRefGoogle Scholar
  293. — 1966: The duplication of chromosomes. Pp. 9–26 in „Probleme der biologischen Reduplikation“. Berlin: Springer-Verlag.CrossRefGoogle Scholar
  294. — and R. D. McMaster, 1954: Autoradiographic and microphotometric studies of desoxyribose nucleic acid during microgametogenesis in Lilium longiflorurn. Chromosoma (Berlin) 6, 489–521.CrossRefGoogle Scholar
  295. P. S. Woods, and W. L. Hughes, 1957: The organization and duplication of chromosomes as revealed by autoradiographic studies using tritium-labelled thymidine. Proc. nat. Acad. Sci. U.S. 43, 122–128.CrossRefGoogle Scholar
  296. Terasima, T., and M. Yasukawa, 1966: Synthesis of Grprotein preceding DNA synthesis in cultured mammalian cells. Exp. Cell Res. 44, 669–672.PubMedCrossRefGoogle Scholar
  297. Terra, N. de, 1967: Macromolecular DNA synthesis in Stentor: regulation by a cytoplasmic initiator. Proc. nat. Acad. Sci. U.S. 57, 607–614.CrossRefGoogle Scholar
  298. Toliver, A., and E. H. Simon, 1967: DNA synthesis in 5-Bromouracil tolerant HeLa cells. Exp. Cell Res. 45, 603–617.PubMedCrossRefGoogle Scholar
  299. Tooze, J., and H. G. Davies, 1963: The occurrence and possible significance of haemoglobin in the chromosomal regions of mature erythrocyte nuclei of the newt Triturus cristatus cristatus. J. Cell Biol. 16, 501–511.PubMedCrossRefGoogle Scholar
  300. Trosko, J. E., and S. Wolff, 1965: Strandedness of Vicia faba chromosomes as revealed by enzyme digestion studies. J. Cell Biol. 26, 125–135.PubMedCrossRefGoogle Scholar
  301. — and J. G. Brewen, 1966: Cytological observations on the strandedness of Mammalian metaphase chromosomes. Cytologia (Tokyo) 31, 208–212.CrossRefGoogle Scholar
  302. Urbani, E., e S. Russo-Caia, 1964: Osservazioni citochimiche e autoradiografiche sul metabolismo degli acide nucleici nella oogenesi di Dytiscus marginalis L. Rend. 1st. Sci. Univ. Camerino 5, 19–50.Google Scholar
  303. Van’tHof, J., 1965: Relationships between mitotic cycle duration, S period duration and the average rate of DNA synthesis in the root meristem cells of several plants. Exp. Cell Res. 39 48–58.CrossRefGoogle Scholar
  304. — 1967: RNA synthesis during G1, S and G2 periods of diploid and colchicine-induced tetraploid cells in the same tissue of Pisum. Exp. Cell Res. 45, 638–645.CrossRefGoogle Scholar
  305. — and A. H. Sparrow, 1963: A relationship between DNA content, nuclear volume and minimum mitotic cycle time. Proc. nat. Acad. Sci. U.S. 49, 897–902.CrossRefGoogle Scholar
  306. Vasil, I. K., 1967: Physiology and cytology of anther development. Biol. Rev. 42, 327–373.PubMedCrossRefGoogle Scholar
  307. Vincent, W. S., 1964: The nucleolus. Proc. XI. Int. Congr. Genetics 2, 343–358.Google Scholar
  308. vonBorstel, R. C, D. M. Prescott, and F. J. Bollum, 1966: Incorporation of nucleotides into nuclei of fixed cells by DNA polymerase. J. Cell Biol. 29, 21–28.CrossRefGoogle Scholar
  309. Walen, K., 1963: The pattern of DNA synthesis in the chromosomes of the marsupial Poiorous tridactylis. Proc. XI. Int. Congr. Genetics 1, 106.Google Scholar
  310. Walker, G. W. R., and K.-P. Ting, 1967: Effect of selenium on recombination in barley. Canad. J. Genet. Cytol. 9, 314–320.PubMedGoogle Scholar
  311. Walker, P. M. B., and H. B. Yates, 1952: Nuclear components of dividing cells. Proc. roy. Soc. (Lond.) B 140, 274–299.CrossRefGoogle Scholar
  312. Warner, J. R., 1967: The species of RNA in the HeLa cell. Pp. 79–99 in “The control of Nuclear Activity”. New Jersey: Prentice Hall.Google Scholar
  313. Went, H. A., 1959: Studies on the mitotic apparatus of the sea urchin by means of antigen-antibody reactions in agar. J. Biophys. Biochem. Cytol. 6, 447–455.PubMedCrossRefGoogle Scholar
  314. Whitten, J. M., 1965: Differential deoxyribonucleic acid replication in the giant foot-pad cells of Sarcophaga bullata. Nature (Lond.) 208, 1019–1021.CrossRefGoogle Scholar
  315. Wilbur, K. M., and N. G. Anderson, 1951: Studies on isolated cell components I. Nuclear isolation by differential centrifugation. Exp. Cell Res. 2, 47–57.CrossRefGoogle Scholar
  316. Williamson, D. H., 1966: Division synchrony in yeasts. Pp. 351–379 in “Synchrony in Cell Division and Growth”. New York: Interscience.Google Scholar
  317. Wilkins, M. H. F., 1956: Physical studies of DNA and nucleoproteins. Cold. Spr. Harb. Symp. quant. Biol. 21, 75–88.CrossRefGoogle Scholar
  318. — and J. T. Randall, 1953: Crystallinity in sperm heads: molecular structure of nucleoprotein in vivo. Biochem. Biophys. Acta 10, 192–193.PubMedCrossRefGoogle Scholar
  319. Wimber, D. E., 1961: Asynchronous replication of deoxyribonucleic acid in root tip chromosomes of Tradescantia paludosa. Exp. Cell Res. 23, 402–407.PubMedCrossRefGoogle Scholar
  320. — and W. Prensky, 1963: Autoradiography with meiotic chromosomes of the male newt (Triturus viridescens) using H3-hymidine. Genetics 48, 1731–1738.PubMedGoogle Scholar
  321. — and H. Quastler, 1963: A thymidine-14C and 3H double labelling technique in the study of cell proliferation in Tradescantia root tips. Exp. Cell Res. 30, 8–22.CrossRefGoogle Scholar
  322. Woodard, J. W., E. Rasch, and H. Swift, 1961: Nucleic acid and protein metabolism during the mitotic cycle in Vicia faba. J. Biophys. Biochem. Cytol. 9, 445–462.PubMedCrossRefGoogle Scholar
  323. Wolf, U., G. Flinspach, R. Bohm, und S. Ohno, 1965: DNS-Reduplikationsmuster bei den Riesen-Geschlechtschromosomen yon Microtus agrestis. Chromosoma (Berlin) 16, 609–617.CrossRefGoogle Scholar
  324. Wolfe, S. L., 1965 a: The fine structure of isolated metaphase chromosomes. Exp. Cell Res. 37, 45–53.CrossRefGoogle Scholar
  325. — 1965 b: The fine structure of isolated chromosomes. J. Ultrastruct. Res. 12, 104–112.PubMedCrossRefGoogle Scholar
  326. — and B. John, 1965: The organization and ultrastructure of male meiotic chromosomes in Oncopeltus fasciatus. Chromosoma (Berlin) 17, 85–103.CrossRefGoogle Scholar
  327. — and J. N. Grim, 1967: The relationship of isolated chromosome fibers to the fibers of the embedded nucleus. J. Ultrastruct. Res. 19, 382–397.PubMedCrossRefGoogle Scholar
  328. Wolff, S., and H. E. Luioppold, 1964: Chromosome splitting as revealed by combined X-ray and labelling experiments. Exp. Cell Res. 34, 548–556.PubMedCrossRefGoogle Scholar
  329. Wolfsberg, M. F., 1964: Cell Population kinetics in the epithelium of the fore-stomach of the mouse. Exp. Cell Res. 35, 119–131.PubMedCrossRefGoogle Scholar
  330. Wolstenholme, D. R., 1965: The distribution of RNA and DNA in salivary gland chromosomes of Chironomus tentans as revealed by fluorescence microscopy. Chromosoma (Berlin) 17, 219–229.CrossRefGoogle Scholar
  331. — 1966: Electron microscope identification of the interphase chromosomes of Amoeba proteus and Amoeba discoides using autoradiography: with some notes on helices and other nuclear components. Chromosoma (Berlin) 19, 449–468.CrossRefGoogle Scholar
  332. — and I. B. Dawid, 1967: Circular mitochondrial DNA from Xenopus laevis and Rana pipiens. Chromosoma (Berlin) 20, 445–449.CrossRefGoogle Scholar
  333. — and H. Ristow, 1968: An electron microscope study of DNA molecules from Chironomus tentans and Chironomus thummi. Genetics 60, 759–770.PubMedGoogle Scholar
  334. Woods, P. S., and M. V. Schaiher, 1959: Distribution of newly synthesized deoxyribonucleic acid in dividing chromosomes. Nature (Lond.) 183, 303–305.CrossRefGoogle Scholar
  335. Yanofsky, S. A., and S. Spiegelmann, 1963: Distinct cistrons for two ribosomal RNA components. Proc. nat. Acad. Sci. U.S. 49, 538–544.CrossRefGoogle Scholar
  336. Zetterberg, A., 1966: Synthesis and accumulation of nuclear and cytoplasmic proteins during interphase in mouse fibroblasts in vitro. Exp. Cell Res. 42, 500–511.PubMedCrossRefGoogle Scholar
  337. Zimmerman, A., 1960: Physico-chemical analysis of the isolated mitotic apparatus. Exp. Cell Res. 20, 529–547.PubMedCrossRefGoogle Scholar
  338. Zubay, G., and P. Doty, 1959: The isolation and properties of deoxyribonucleo-protein particles containing single nucleic acid molecules. J. molec. Biol. 1, 1–20.CrossRefGoogle Scholar

Copyright information

© Springer-Gerlag/Wien 1969

Authors and Affiliations

  • Bernard John
    • 1
  • Kenneth R. Lewis
    • 2
  1. 1.Department of GeneticsThe UniversityBirminghamEngland
  2. 2.Botany SchoolThe UniversityOxfordEngland

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