Compartmental Models in the Analysis of Intestinal Absorption

  • Giorgio Segre
Conference paper


The kinetics of intestinal absorption can receive a simple mathematical formulation through the application of compartmental models. If one assumes the linearity of the system under analysis and calls X (t) the function which represents the fractional concentration in blood of a given substance at time t and X + (t) the function which represents the fractional concentration at time t of the same substance when given by mouth, (then between the two functions it is possible to write the equation
$$ {X^{ + }}\left( t \right) = \int\limits_{0}^{t} {G\left( \tau \right)X\left( {t - \tau } \right)} d\tau $$


Intestinal Absorption Compartmental Model Fractional Concentration Transfer Constant Extravascular Space 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Rescigno, A., and G. Segre, 1966: Drug and Tracer Kinetics, Blaisdell, Walitham.Google Scholar
  2. [2]
    Phillips, D. L., 1962: J. Ass. Comp. Mach. 9, 84.CrossRefGoogle Scholar
  3. [3]
    Rescigno, A., and G. Segre, 1961: J. Theoret. Biol. 1, 498.Google Scholar
  4. [4]
    Beck, J., and A. Rescigno, 1964: J. Theoret. Biol. 6, 1.CrossRefGoogle Scholar
  5. [5]
    Garrett, E. R., R. C. Thomas, D. P. Wallach, and C. D. Alway, 1960: J. Pharmacol. Exper. Ther. 130, 106.Google Scholar
  6. [6]
    Taylor, J. D, and R. G. Wiegand, 1962: Clin. Pharmacol. Ther. 3, 464.PubMedGoogle Scholar
  7. [7]
    Silverman, M., and A. S. V. Burgen, 1961: J. Appl. Physiol. 16, 911.PubMedGoogle Scholar
  8. [8]
    Uffer, M. B., and C. W. Sheppard, 1961 : Rev. Sci. Instr. 32, 1413.CrossRefGoogle Scholar
  9. [9]
    Sheppard, C. W., 1962: Basic Principles of the Tracer Method, Wiley, New York.Google Scholar
  10. [10]
    Schiender, B., and E. Krüger-Thiemer, 1962: Arzneimittelf. 12, 992.Google Scholar
  11. [11]
    Krüger-Thiemer, E., and B. Schiender, 1963: Arzneimittelf. 13, 891.Google Scholar
  12. [12]
    Krüger-Thiemer, E., and B. Schiender, and J. Seydel, 1963: Arzneimittelf. 13, 894.Google Scholar
  13. [13]
    Wiegand, R. G., and P.G. Sanders, 1964: J. Pharmacol. Exper. Ther. 146, 271.Google Scholar
  14. [14]
    Berman, M., E. Shahn, and M. F. Weiss, 1962: Biophys. J. 2, 275.PubMedCrossRefGoogle Scholar
  15. [15]
    Berman, M., M. F. Weiss, and E. Shahn, 1962: Biophys. J. 2, 289.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • Giorgio Segre
    • 1
  1. 1.Department of PharmacologyUniversity of CamerinoItaly

Personalised recommendations