The Enzymatic Basis for the Active Transport of Sodium and Potassium

  • Jens Chr. Skou
Conference paper


The main problem in relation to active transport of Na and K is how metabolic energy is translated into a movement of ions against an electrochemical gradient. The first step on the way to solving this problem was the demonstration that active transport is driven by ATP (Caldwell 1956, Caldwell and Keynes 1957, Dunham 1957, Witham 1958, Caldwed1, Hod gki n and Shaw 1959, Caldwell 1960, Caldwell, Hodgkin, Keynes and Shaw 1960, Hoffman 1960). A second step may be the isolation of the Na + K activated enzyme system (Skou 1957) and the demonstration that this enzyme system is (involved in the active transport of Na and K across the cell membrane (for references see Skou 1965 a).


Active Transport Enzyme System Sodium Potassium Squid Axon Adenosine Tripho 
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Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • Jens Chr. Skou
    • 1
  1. 1.Institute of PhysiologyUniversity of AarhusDenmark

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