Since the introduction of the carrier concept by Osterhout in 1935 [8] this notion has been used in the discussion of biological transport phenomena in increasing measure. This is mainly due to two types of observations: 1. pronounced structural specificity of penetration, resembling in many cases the stereo-specificity of enzymatic reaction and indicating an essential role of chemical reactivity; 2. observations pointing to a limited transport capacity, i.e. saturation kinetics and competition.


Perfuse Heart Saturation Kinetic Induce Movement Carrier Mechanism Biological Transport 
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  1. [1]
    Adrian, R. H., 1962: Symp. on The Plasma Membrane, Suppl. to Circulation 26, 1214–1223.Google Scholar
  2. [2]
    Crofford, O. B., and A. E. Renold, 1965: J. Biol, Chem. 249, 3237–3244.Google Scholar
  3. [3]
    Keynes, R. D.: This symposium.Google Scholar
  4. [4]
    Fisher, R. B., 1961: In: “Enzymes and Drug Action,” Ciba Foundation Symp. (J. L. Mongar and A. V. S. de Reuck, editors) p. 83–94.Google Scholar
  5. [5]
    LeFevre, P. G., 1955: Protoplasmatologia VIII/7 A, 1–123.Google Scholar
  6. [6]
    Morgan, H. E., M. J. Henderson, D. M. Regen, and C. R. Park, 1961: J. Biol. Chem. 236, 253–261.PubMedGoogle Scholar
  7. [7]
    Müller, P., 1965: J. Physiol. 177, 453–462.Google Scholar
  8. [8]
    Osternout, W. J. V., 1935: Proc. Nat. Acad. Sci., U.S. 21, 125–132.CrossRefGoogle Scholar
  9. [9]
    Rosenberg, T., and W. Wilbrandt, 1957: J. Gen. Physiol. 41, 289–296.PubMedCrossRefGoogle Scholar
  10. [10]
    Rosenberg, T., and W. Wilbrandt, 1963: J. Theoret. Biol. 5, 288–305.CrossRefGoogle Scholar
  11. [11]
    Shaw, T. L. 1954: Ph. D.-Thesis, Cambridge University, England 1954 (quoted from Glynn, Progress Biophys. 8, 241–307, 1957).Google Scholar
  12. [12]
    Solomon, A. K., 1952/53: J. Gen. Physiol. 36, 57–110.PubMedCrossRefGoogle Scholar
  13. [13]
    Stein, W. D.: Discussion remark at this symposium1.Google Scholar
  14. [14]
    Widdas, W. F., 1952: J. Physiol. 118, 23–39.PubMedGoogle Scholar
  15. [15]
    Widdas, W. F., 1954: J. Physiol. 125, 163–180.PubMedGoogle Scholar
  16. [16]
    Wilbrandt, W., 1954: Symp. Soc. exp. Biol. 8, 136–162.Google Scholar
  17. [17]
    Wilbrandt, W., 1956: J. cell. comp. Physiol. 47, 137–145.CrossRefGoogle Scholar
  18. [18]
    Wilbrandt, W., 1965: Folia Haematologica, p. 5–13.Google Scholar
  19. [19]
    Wilbrandt, W., et al.: Unpublished data.Google Scholar
  20. [20]
    Wilbrandt, W., S. Frei, and T. Rosenberg, 1956: Exper. Cell Res. 11, 59–66.CrossRefGoogle Scholar
  21. [21]
    Wilbrandt, W., and A. Kotyk, 1964: Arch. exp. Path. Pharm. 249, 279–287.CrossRefGoogle Scholar
  22. [22]
    Wilbrandt, W., and T. Rosenberg, 1961: Pharmacol. Rev. 13, 109–183.PubMedGoogle Scholar

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© Springer-Verlag/Wien 1967

Authors and Affiliations

  • W. Wilbrandt
    • 1
  1. 1.Department of PharmacologyUniversity of BerneSwitzerland

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