Mitochondrial Cristae during Liver Regeneration

  • Albert Claude
Conference paper


Elongated, dumbbell-shaped mitochondria, containing longitudinal stacks of lamellae, have been described in the liver of rats subjected to certain toxic agents, such as ammonium carbonaie or dinitrophenol; their occurrence and particular morphology have been considered to be the expression of degenerative processes, and the intramitochondrial lamellae likened to myelin figures [1, 2]. Dumbbell-shaped or elongated forms of mitochondria, with apparently concentric longitudinal cristae have been observed in rats following administration of thyroxine in excess [3]. Lehninger has pointed out that the latter extended or dumbbell-shaped configurations may be related to mitochondrial growth and division [4].


Endoplasmic Reticulum Liver Regeneration Dense Granule Smooth Endoplasmic Reticulum Tangential Section 


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Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • Albert Claude
    • 1
  1. 1.Laboratoire de Cytologie et de Cancérologie ExpérimentaleFree University of BrusselsBrusselsBelgium

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