Structure and Physical Chemistry of Membranes

  • B. A. Pethica
Conference paper


This article is not intended as a review either of the proceedings of part of this conference or of the current position in the study of the structure of biological membranes. Indeed, it would be presumptuous for a physical chemist to attempt either review. In the present state of membrane studies there is a happy symbiosis between the cell cytologists and the physical scientists. The physical chemist should not attempt to fit the variety of biological experience into the Procrustean bed of oversimplified models and theory and finds more problems than solutions. The remarks which follow are intended as a commentary on current theories of certain aspects of membrane structure and as an indication of future lines of physical research both in model and membrane systems.


Unit Membrane Membrane Sheet Powder Diagram Model Lipid System Fatty Acid Monolayer 


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  1. [1]
    Robertson, J. D., 1963: Unit Membranes; a Review etc. Symp. Soc. Study Develop. Growth 22, 1–81 (Michael Locke, editor). New York, Academic Press, 1964.Google Scholar
  2. [2]
    Elbers, P. F., 1964: Recent Progress in Surface Science 2, 443.Google Scholar
  3. [3]
    Pethica, B. A., 1964: Society of Chemical Industry Symposium on Surface Activity and the Bacterial Cell (in press).Google Scholar
  4. [4]
    Kavanau, J. L., 1965: Structure and Function in Biological Membranes. 2 Vols. London, Holden-Day, Inc.Google Scholar
  5. [5]
    Danielli, J. F., and H. A. Davson, 1935: J. Cellular Comp. Physiol. 5, 495.CrossRefGoogle Scholar
  6. [6]
    Glauert, A. M., and J. A. Lucy, 1965: This Conference.Google Scholar
  7. [7]
    Lucy, J. A., 1964: J. Theoret. Biol. 7, 360.CrossRefGoogle Scholar
  8. [8]
    Sjöstrand, F. S., 1965: This Conference.Google Scholar
  9. [9]
    Sjöstrand, F. S., 1963: J. Ultrastructure Res. 9, 340 and 561.CrossRefGoogle Scholar
  10. [10]
    Fernandez Moran, H., 1964: J. Cell. Biol. 22, 63.PubMedCrossRefGoogle Scholar
  11. [11]
    Green, D. E., and S. Fleischer, 1963: Biochem. Biophys. Acta 70, 554.PubMedCrossRefGoogle Scholar
  12. [12]
    Finean, I. B., and M. G. Rumsby, 1963: Nature 197, 1326.CrossRefGoogle Scholar
  13. [13]
    Aristolle, 330 B. C.: Nichomachean Ethics. Book 1, Chap. 3.Google Scholar
  14. [14]
    Van Deenen, L. L. M., 1965: This Conference.Google Scholar
  15. [15]
    Einstein, A., 1910: Ann. Physik. 33, 1275.CrossRefGoogle Scholar
  16. [16]
    Volmer, M., 1939: Kinetik der Phasenbildung (Leipzig). See also Faraday Society Discussions 5, 1949 for a number of papers on crystallisation.Google Scholar
  17. [17]
    Hill, T. L., 1963, 1964: Thermodynamics of Small Systems. Vols. 1 and 2. Benjamin, New York.Google Scholar
  18. [18]
    Hall, D. G., and B. A. Pethica, 1965: In: Non-ionic Surfactants. Editor: M. J. Schick, Marcel Dekker, p. 516–557.Google Scholar
  19. [19]
    Hall, D. G., and B. A. Pethica, 1965: Unpublished work. Unilever Research Laboratory, Port Sunlight, England.Google Scholar
  20. [20]
    Kung, H. C., and E. D. Goddard, 1963: J. Phys. Chem. 67, 1965.CrossRefGoogle Scholar
  21. [21]
    Kung, H. C., and E. D. Goddard, 1964: J. Phys. Chem. 68, 3465.CrossRefGoogle Scholar
  22. [22]
    VanSenden, K. G., and H. L. Spier, 1965: Unilever Research Laboratory, Vlaardingen, Holland. Private Communication.Google Scholar
  23. [23]
    Chapman, D., and D. T. Collin, 1965: Nature 206, 189.PubMedCrossRefGoogle Scholar
  24. [24]
    Dervichian, D. G., 1964: Progress in Biophysics and Molecular Biology 14, 265.CrossRefGoogle Scholar
  25. [25]
    DeGier, J., L. L. M. van Deenen, and K. G. van Senden, 1965: Experientia (in the press).Google Scholar
  26. [26]
    Iles, D. H., J. Mingins, and B. A. Pethica: Unpublished data.Google Scholar
  27. [27]
    Koenig, F. O., 1951: Compt, rend. Réunion Comité Thermodynam. et Cinétiq. Electrochim. 299.Google Scholar
  28. [28]
    Keynes, R. D., 1965: This Conference.Google Scholar
  29. [29]
    Keynes, R. D., and X. Aubert, 1964: Nature 203, 261.PubMedCrossRefGoogle Scholar
  30. [30]
    Luzzati, V., and F. Reiss-Husson, 1965: This Conference.Google Scholar
  31. [31]
    Luzzati, V., and F. Reiss-Husson, 1962: J. Cell. Biol. 12, 207.PubMedCrossRefGoogle Scholar
  32. [32]
    Luzzati, V., H. Mustacchi, and A. Skoulios, 1957: Nature 180, 600.CrossRefGoogle Scholar
  33. [33]
    Luzzati, V., H. Mustacchi, and A. Skoulios, 1958: Faraday Society Discussions 25, 43.CrossRefGoogle Scholar
  34. [34]
    Skoulios, A., and V. Luzzati, 1961: Acta. Cryst. 14, 278.CrossRefGoogle Scholar
  35. [35]
    Luzzati, V., H. Mustacchi, A. Skoulios, and F. Reiss-Husson, 1960: Acta. Cryst. 13, 660.CrossRefGoogle Scholar
  36. [36]
    Finean, J. B., 1962: Circulation 26, 1151.Google Scholar
  37. [37]
    Segerman, E., 1965: In: Surface Chemistry, Proceedings of IInd Scand. Symp. on Surface Activity. Editor: Vera Runnström-Reio, Munksgaard, Copenhagen, p. 157–180.Google Scholar
  38. [38]
    Daniel, Vera, 1953: Adv. Physics 2, 450.CrossRefGoogle Scholar
  39. [39]
    Shipley, G. G., 1965: Unpublished observations. Unilever Research Laboratory, Welwyn, England.Google Scholar
  40. [40]
    Segerman, E., 1965: Unpublished observations. Unilever Research Laboratory, Port Sunlight, England.Google Scholar
  41. [41]
    McQuillen, K., 1960: The Bacteria. Editors: I. C. Gunsalus and K. Y. Stanier, Academic Press, New York, Vol. 1, p. 249.Google Scholar
  42. [42]
    Chapman, D., 1965: The Structure of Lipids. Methuen, London.Google Scholar
  43. [43]
    Baker, P. F., A. L. Hodgkin, and T. I. Shaw, 1962: J. Physiol. 164, 330.PubMedGoogle Scholar
  44. [44]
    Oster, G., 1948: Chem. Rev. 43, 319.PubMedCrossRefGoogle Scholar
  45. [45]
    Vandenheuvel, F. A., 1963: J. Amer. Oil and Colour Chemists, Soc. 40, 455.CrossRefGoogle Scholar
  46. [46]
    Chapman, D., N. F. Owens, and D. A. Walker, 1965: Private Communication. Unilever Research Laboratory, Welwyn, England.Google Scholar
  47. [47]
    Kavanau, J. L., 1964: Water and Solute-water Interactions. London, Holden-Day Inc.Google Scholar
  48. [48]
    Nemethy, G., and H. A. Scheraga, 1962: J. Phys. Chem. 66, 1773.CrossRefGoogle Scholar
  49. [49]
    Nemethy, G., and H. A. Scheraga, 1963: J. Phys. Chem. 67, 2888.CrossRefGoogle Scholar
  50. [50]
    Vand, V., and W. A. Senior, 1965: J. Chem. Phys. 43, 1869, 1873, 1878.CrossRefGoogle Scholar
  51. [51]
    Clifford, J., W. A. Senior, and B. A. Pethica, 1964: Symposium on Water in Biologic Systems. Ann. N. Y. Acad. Sci. (in the press).Google Scholar
  52. [52]
    Johnson, G. A., J. Goldfarb, and B. A. Pethica, 1965: Trans. Far. Soc. 61, 2321.CrossRefGoogle Scholar
  53. [53]
    Johnson, G. A., S. M. Lecchini, J. Clifford, B. Sheard, and B. A. Pethica: Unpublished data. Unilever Research Laboratory, Port Sunlight, England.Google Scholar
  54. [54]
    Pethica, B. A.: This Conference.Google Scholar

Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • B. A. Pethica
    • 1
  1. 1.Unilever Research LaboratoryPort Sunlight, CheshireEngland

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