Electrolyte and Water Transport across Epithelial Cells

  • A. Leaf
  • N. S. Lichtenstein
  • M. M. Civan
Conference paper


We have been studying the urinary bladder of the toad, Bufo marinus, as a model transporting epithelium which actively moves sodium from urine to body fluids [1, 2]. The results of two recent studies, which relate to the functional structure of this tissue and to how its permeability properties are modified by vasopressin, will be presented.


Sodium Transport Bathing Medium Toad Bladder Mucus Secreting Cell National Heart Institute 
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  1. [1]
    Leaf, A., J. Anderson, and L. B. Page, 1958: Active sodium transport by the isolated toad bladder. J. Gen. Physiol. 41, 657.PubMedCrossRefGoogle Scholar
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    Frazier, H. S., and A. Leaf, 1964: Cellular mechanisms in the control of body fluids. Medicine 43, 281.PubMedGoogle Scholar
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    Ewer, R. F., 1952: The effect of pituitrin on fluid distribution in Bufo regularis Reuss. J. Exper. Biol. 29, 173.Google Scholar
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    Lichtenstein, N. S., and A. Leaf, 1965: Effect of amphotericin B on the permeability of the toad bladder. J. Clin. Invest. 44, 1328.PubMedCrossRefGoogle Scholar
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    Frazier, H. S., E. F. Dempsey, and A. Leaf, 1962: Movement of sodium across the mucosal surface of the isolated toad bladder and its modification by vasopressin. J. Gen. Physiol. 45, 529.PubMedCrossRefGoogle Scholar
  8. [8]
    Civan, M. M., O. Kedem, and A. Leaf: Effect of vasopressin on toad bladder under conditions of zero net sodium transport. Amer. J. Physiol. (in press).Google Scholar

Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • A. Leaf
    • 1
  • N. S. Lichtenstein
    • 1
  • M. M. Civan
    • 1
  1. 1.Departments of Medicine, Harvard Medical SchoolMassachusetts General HospitalBostonUSA

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