Lysosomes and Phagosomes

The Vacuolar Apparatus
  • Christian de Duve
Conference paper


Lysosomes were first described as cell particles or granules. I am now inclined to call them vacuoles, even when they appear as compact bodies, in order to emphasize the essentially extracellular character of their contents. Together with the phagosomes, they form what is conveniently referred to as the vacuolarapparatus [1], an intracellular digestive system comparable, except for its discontinuity, to the digestive tract of higher organisms. Each vacuole is to some extent equivalent to a certain segment of this digestive tract.


Zymogen Granule Secondary Lysosome Compact Body Vacuolar System Complex Phen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. [1]
    Schmidt, W., 1962: Z. Zellforsch. 58, 573.PubMedCrossRefGoogle Scholar
  2. [2]
    de Duve, C., and R. Wattiaux, 1966: Ann. Rev. Physiol. 28, 435.CrossRefGoogle Scholar
  3. [3]
    Cohn, Z. A., and B. Benson, 1965: J. Exper. Med. 121, 153, 279, 835;CrossRefGoogle Scholar
  4. [3a]
    Cohn, Z. A., and B. Benson, 1965: J. Exper. Med. 122, 455.CrossRefGoogle Scholar
  5. [4]
    Cohn, Z. A., J. G. Hirsch, and M. E. Fedorko, 1966: J. Exper. Med. 123, 747.CrossRefGoogle Scholar
  6. [5]
    Cohn, Z. A., M. E. Fedorko, and J. G. Hirsch, 1966: J. Exper. Med. 123, 757.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • Christian de Duve
    • 1
    • 2
  1. 1.The Rockefeller UniversityNew YorkUSA
  2. 2.University of LouvainBelgium

Personalised recommendations