Effect of 5-Hydroxytryptamine on Sodium Transport across Bullfrog Skin

  • Charles V. Paganelli
  • Suk Ki Hong
Conference paper


5-hydroxytryptamine (5 HT) has been shown to promote the reabsorption of sodium by the renal tubule (Blackmore 1958, Little et al. 1961); it is also considered as an inhibitory transmitter substance in the central nervous system (Brodie and Shaw 1957, Twarog 1954). Despite these and other important rôles played by 5HT, its effect on membrane permeability and transport in relatively well-defined systems is not known. Hence, this investigation was undertaken to study the effect of 5HT on sodium transport across frog skin.


Sodium Transport Frog Skin Sulfate Complex Sodium Influx Sodium Flux 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Blackmore, W. P., 1958: Amer. J. Physiol. 193, 639–643.PubMedGoogle Scholar
  2. Brodie, B. B., and P. A. Shaw, 1957: Ann. N. Y. Acad. Sci. 66, 631–642.PubMedCrossRefGoogle Scholar
  3. Curran, P. F., and J. R. Gill, 1962: J. Gen. Physiol. 45, 625–641.PubMedCrossRefGoogle Scholar
  4. Little, J. M., E. A. Angell, W. Huffmann, and W. Brooks, 1961: J. Pharmacol. Exper, Therap. 131, 44–48.Google Scholar
  5. Twarog, B. M., 1954: J. Cellular Comp. Physiol. 44, 141–163.CrossRefGoogle Scholar
  6. Ussing, H. H., and K. Zerahn, 1951: Acta Physiol. Scand. 23, 110–127.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag/Wien 1967

Authors and Affiliations

  • Charles V. Paganelli
    • 1
  • Suk Ki Hong
    • 1
  1. 1.Department of PhysiologyState University of New York at BuffaloNew YorkUSA

Personalised recommendations