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Cytochemistry of the Histones

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Chemistry and Cytochemistry of Nucleic Acids and Nuclear Proteins

Part of the book series: Protoplasmatologia ((2123,volume 5 / 3a-d))

Abstract

The histones and protamines were discovered along with the nucleic acids late in the last century by Friedrich Miescher 1. They were part of the “nuclein”, first extracted by Miescher in 1869 from pus cell nuclei obtained from old bandages gotten from the hospitals of Tübingen (Miescher 1897). This hard won material was one of a class of biological substances, including casein and phosphoproteins of egg yolk, which were then considered to be unique because of their acidic properties and phosphorus content. Twenty years later however, as the means were devised by Altmann (1889) for resolving the nuclein into its component parts, and the attributes which had previously aroused the most curiosity were found to reside in the nucleic acid portion, most attention was directed toward this substance and the associated proteins were treated as an unwanted by-product obtained during its isolation.

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  1. Botany Department, The University of Texas, Austin, Texas, USA

    David P. Bloch

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Bloch, D.P. (1966). Cytochemistry of the Histones. In: Chemistry and Cytochemistry of Nucleic Acids and Nuclear Proteins. Protoplasmatologia, vol 5 / 3a-d. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5569-1_4

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  • DOI: https://doi.org/10.1007/978-3-7091-5569-1_4

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