Abstract
Metachromasy exists when a pure dye stains a tissue section in a hue perceptibly different from the color characteristically associated with a dye. Thus, a dilute solution of toluidine blue is blue. Cell nuclei and certain basophilic components of the cytoplasm are stained in this color. A number of other histological elements are stained red by toluidine blue. The latter is the metachromatic color of the dye. Both extremes of color, as well as intermediate hues, may prevail in the same histological preparation.
Certain statements in this paper refer to original work supported by grants-in-aid from the A. D. Williams Memorial Fund, Medical College of Virginia, and from the National Institutes of Health (G-4212), United States Public Health Service
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Addendum
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Kelly, J.W. (1956). The Metachromatic Reaction. In: The Metachromatic Reaction. Protoplasmatologia, vol 2 / D / 2. Springer, Vienna. https://doi.org/10.1007/978-3-7091-5529-5_1
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