The Metachromatic Reaction

  • John W. Kelly
Part of the Protoplasmatologia book series (PROTOPLASMATOL., volume 2 / D / 2)


Metachromasy exists when a pure dye stains a tissue section in a hue perceptibly different from the color characteristically associated with a dye. Thus, a dilute solution of toluidine blue is blue. Cell nuclei and certain basophilic components of the cytoplasm are stained in this color. A number of other histological elements are stained red by toluidine blue. The latter is the metachromatic color of the dye. Both extremes of color, as well as intermediate hues, may prevail in the same histological preparation.


Mast Cell Hyaluronic Acid Methylene Blue Chondroitin Sulfate Toluidine Blue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag 1956

Authors and Affiliations

  • John W. Kelly
    • 1
  1. 1.Department of AnatomyMedical College of VirginiaRichmondUSA

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