The Permeability Characteristics of the Nuclear Envelope at Interphase

  • C. M. Feldherr
  • C. V. Harding
Part of the Protoplasmatologia book series (PROTOPLASMATOL., volume 5 / 2)


It is well known that a variety of essential cellular processes are dependent either wholly, or in part, on the cell nucleus. Similarly, the nucleus, in order to carry out its functions, is dependent on the cytoplasm (Brachet 1957; Mirsky and Osawa 1961). The materials which are responsible for these interactions must, in some way, cross the nuclear envelope. For this reason, knowledge of the permeability characteristics of the nuclear envelope can be of considerable value in understanding the interactions and exchanges that take place between the nucleus and the cytoplasm. For example, if the permeability characteristics of the nuclear envelope were fully understood, one should know in what specific form and by what mechanism RNA can pass from the nucleus into the cytoplasm, what substances, due to their inability to cross the nuclear envelope, would have to be synthesized in the region of the cell where they are located. Furthermore, as the mechanisms of such exchanges become known, it may be possible to alter the interactions between the nucleus and the cytoplasm and thus control various physiological processes.


Nuclear Envelope Intact Cell Nuclear Membrane Permeability Characteristic Colloidal Gold Particle 
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Copyright information

© Springer-Verlag / Wien 1964

Authors and Affiliations

  • C. M. Feldherr
    • 1
    • 2
    • 3
  • C. V. Harding
    • 1
    • 2
    • 3
  1. 1.Department of PhysiologyUniversity of AlbertaEdmontonCanada
  2. 2.Department of Ophthalmology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Department of Physiology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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