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The Permeability Characteristics of the Nuclear Envelope at Interphase

  • C. M. Feldherr
  • C. V. Harding
Part of the Protoplasmatologia book series (PROTOPLASMATOL., volume 5 / 2)

Abstract

It is well known that a variety of essential cellular processes are dependent either wholly, or in part, on the cell nucleus. Similarly, the nucleus, in order to carry out its functions, is dependent on the cytoplasm (Brachet 1957; Mirsky and Osawa 1961). The materials which are responsible for these interactions must, in some way, cross the nuclear envelope. For this reason, knowledge of the permeability characteristics of the nuclear envelope can be of considerable value in understanding the interactions and exchanges that take place between the nucleus and the cytoplasm. For example, if the permeability characteristics of the nuclear envelope were fully understood, one should know in what specific form and by what mechanism RNA can pass from the nucleus into the cytoplasm, what substances, due to their inability to cross the nuclear envelope, would have to be synthesized in the region of the cell where they are located. Furthermore, as the mechanisms of such exchanges become known, it may be possible to alter the interactions between the nucleus and the cytoplasm and thus control various physiological processes.

Keywords

Nuclear Envelope Intact Cell Nuclear Membrane Permeability Characteristic Colloidal Gold Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Bibliography

  1. Abelson, P. H., and W. R. Duryee, 1949: Biol. Bull. 96, 205.PubMedCrossRefGoogle Scholar
  2. Afzelius, B. A., 1955: Exper. Cell Res. 8, 147.CrossRefGoogle Scholar
  3. Allfrey, Y. G., R. Meudt, J. W. Hopkins, and A. E. Mirsky, 1961: Proe. Nat. Acad. Sei. 47, 907.Google Scholar
  4. Anderson, N. G., 1953: Exper. Cell Res. 5, 361.CrossRefGoogle Scholar
  5. Anderson, E., and H. W. Beams, 1956: J. Biophys. Biocliem. Cytol. 2, Suppl. 4, 439.CrossRefGoogle Scholar
  6. Anderson, E., and K. M. Wilbur, 1951: J. Gen. Physiol. 34, 647. 1952: J. Gen. Physiol. 35, 781.Google Scholar
  7. Battin, W. T., 1959: Exper. Cell Res. 17, 59.CrossRefGoogle Scholar
  8. Baud, C. A., 1959: in: Problèmes d’Ultrastructures et de Fonctions nucléaires (Ed. J. Andre Thomas). Paris. Masson et Cie., 1.Google Scholar
  9. Beck, L. Y., and H. Shapiro, 1936: Proc. Soc. Exper. Biol. Med. 34, 170.Google Scholar
  10. Becker, F. F., and H. Green, 1960: Exper. Cell Res. 19, 361.CrossRefGoogle Scholar
  11. Bennett, H. S., 1956: J. Biophys. Bioehem. Cytol. 2, Suppl. 4, 99.CrossRefGoogle Scholar
  12. Brächet, J., 1955: Nature 175, 851.PubMedCrossRefGoogle Scholar
  13. Brächet, J., 1956: Bioehim. et Biophys. Acta 19, 583.Google Scholar
  14. Brächet, J., 1957: Biochemical Cytologv. Academic Press, New York.Google Scholar
  15. Buck, J. B., and R. D. Boche, 1938: Biol. Bull. 75, 344.Google Scholar
  16. Byers, T. J., D. B. Platt, and L. Goldstein, 1963: J. Cell Biol. 19, 453.PubMedCrossRefGoogle Scholar
  17. Callan, H. G., 1949: Hereditas, Suppl. 35, 547.Google Scholar
  18. Callan, H. G., 1952: Svmposia Soe. Exper. Biol. 6, 243.Google Scholar
  19. Clark, A. M., 1943: Austral. J. Exper. Biol. a. Med. Sei. 21, 215.Google Scholar
  20. Clark, W. H. Jr., 1960: J. Biophys. Bioehem. Cytol. 7, 345. Churney, L., 1942: Biol. Bull. 82, 52.Google Scholar
  21. Duryee, W. R., 1940: Proc. 8th Amer. Sei. Congr. 3, 45.Google Scholar
  22. Feldherr, C. M., 1962a: J. Cell Biol. 14. 65.PubMedCrossRefGoogle Scholar
  23. Feldherr, C. M., 1962b: J. Cell Biol. 12. 159.PubMedCrossRefGoogle Scholar
  24. Feldherr, C. M., 1963: Fed. Proc. 22, 179.Google Scholar
  25. Feldherr, C. M., Unpublished observations.Google Scholar
  26. Feldherr, C. M., and A. B. Feldherr, 1960: Nature 185. 250.PubMedCrossRefGoogle Scholar
  27. Feldherr, C. M., and J. M. Marshall, 1962: J. Cell Biol. 12, 640.PubMedCrossRefGoogle Scholar
  28. Fica, A., and M. Errera, 1955: Arch. Inter, de Physiol, et de Biochim. 63, 259.CrossRefGoogle Scholar
  29. Fischer, H., and L. Wagner, 1954: Naturwissenschaften 41, 532.CrossRefGoogle Scholar
  30. Gall, J. G., 1964: Protoplasmatologia V /2, 4.Google Scholar
  31. Gay, H., 1956: J. Biophys. Biochem. Cytol. 2, Suppl. 4, 40.Google Scholar
  32. Goldstein, L., 1958: Exper. Cell Res. 15, 635.CrossRefGoogle Scholar
  33. Goldstein, L., and C. Y. Harding, 1950: Fed. Proc. 9, 48.Google Scholar
  34. Goldstein, L., and W. Plaut, 1955: Proc. Nat. Acad. Sei. 411, 874.Google Scholar
  35. Hamburger, H. V., 1904: Bd. Ill, Wiesbaden.Google Scholar
  36. Harding, C. V., and C. M. Feldherr, 1959: J. Gen. Physiol. 42, 1155.Google Scholar
  37. Holter, H., 1959: Ann. N. Y. Acad. Sei. 78, 524.Google Scholar
  38. Holtfreter, V., 1954: Exper. Cell Res. 7, 95.CrossRefGoogle Scholar
  39. Holtzer, H., and S. Holtzer, 1960: Compt. rend. trav. Lab. Carlsberg, Ser. Chim. 31, 373.Google Scholar
  40. Hunter, A. S., and F. R. Hunter, 1961: Exper. Cell Res. 22, 609.CrossRefGoogle Scholar
  41. Loewenstein, W. R., and Y. Kanno, 1963: J. Cell Biol. 16, 421.PubMedCrossRefGoogle Scholar
  42. Merriam, R. W., 1959 a: J. Biophys. Biochem. Cytol. 5, 117.Google Scholar
  43. Merriam, R. W., 1959 b: J. Biophys. Biochem. Cytol 6, 353.Google Scholar
  44. Mirsky, A. E., and S. Osawa, 1961: in: The Cell (J. Brächet and A. E. Mirsky editors). Academic Press, New York, 2, 677.Google Scholar
  45. Monne, L., 1935: Proc. Exper. Biol. Med. 32, 1197.Google Scholar
  46. Moore, R. O., Y. R. Mumav, and M. D. Schoenberg, 1961: J. Ultrastruct. Res. 5, 244.Google Scholar
  47. Moses, M. I., 1956: J. Bionhvs. Biochem. Cytol. 2. Suppl. 4, 397.CrossRefGoogle Scholar
  48. Nachmius, Y. T., and J. M. Marshall, 1961: in: Biological Structure and Function. Proc. 1st IUB/1UBS Joint Symposium (T. W. Goodwin and O. Lindberg editors), New York, Academic Press.Google Scholar
  49. Naora, H., H. Naora, M. Izawa, Y. G. Allfrey, and A. E. Mirsky, 1962: Proc. Nat. Acad. Sei. 48, 853.Google Scholar
  50. Pappas, G. D., 1956: J. Biophys. Biochem. Cytol. 2, Suppl. 4, 431.CrossRefGoogle Scholar
  51. Pollister, A. W., M. E. Gettner, and R. Ward, 1954: Science 120, 789.Google Scholar
  52. Shinke,N., 1937: Cvtologia, Fujii Jubilee Yolumen 449.Google Scholar
  53. Stern, H., and A. E. Mirsky, 1953; J. Gen. Physiol. 37, 177.Google Scholar
  54. Swift, H., 1956: J. Biophys. Biochem. Cytol. 2, Suppl. 4, 415.CrossRefGoogle Scholar
  55. Watson, M., L1955: J. Biophys. Biochem. Cytol. 1, 257.Google Scholar
  56. Watson, M., 1959: J. Biophys. Biochem. Cytol. 6, 147.Google Scholar
  57. Whaley, W. G., H. H. Mollenhauer, and Y. H. Leech, 1960: J. Biophys. Biochem. Cytol. 8, 233.Google Scholar
  58. Wischnitzer, S., 1958: J. Ultrastruct. Res. 1, 201.Google Scholar
  59. Wischnitzer, S., 1960: Inter. Rev. Cytol. 10, 137.Google Scholar

Copyright information

© Springer-Verlag / Wien 1964

Authors and Affiliations

  • C. M. Feldherr
    • 1
    • 2
    • 3
  • C. V. Harding
    • 1
    • 2
    • 3
  1. 1.Department of PhysiologyUniversity of AlbertaEdmontonCanada
  2. 2.Department of Ophthalmology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  3. 3.Department of Physiology, College of Physicians and SurgeonsColumbia UniversityNew YorkUSA

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