Profound Hypothermia and Total Circulatory Arrest in Neurosurgery: Methods, Results, and Physiologic Effects

  • J. D. Michenfelder
  • A. Uihlein
  • C. S. MacCarty
  • H. R. TerryJr.
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 13)


Until recently hypothermia in neurosurgery had been limited to surface technics and temperatures of about 28° C; the potential hazard of ventricular fibrillation precluded further cooling. The development of extracorporeal perfusion technics has effectively circumvented this limiting factor, permitting temperatures to be lowered to 15° C and below with little additional hazard to the patient. At these temperatures the oxygen requirements are such that the brain and other vital organs can withstand total circulatory arrest for periods of 30 to 40 minutes without apparent damage.


Intracranial Aneurysm Circulatory Arrest Stroke Index Cent Carbon Dioxide Profound Hypothermia 
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Copyright information

© Springer-Verlag/Wien 1964

Authors and Affiliations

  • J. D. Michenfelder
    • 1
  • A. Uihlein
    • 1
  • C. S. MacCarty
    • 1
  • H. R. TerryJr.
    • 1
  1. 1.Mayo Clinic and Mayo FoundationRochesterUSA

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