Physiopathology, Methods and Clinical Results of Selective Brain Cooling

  • K. Kristiansen
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 13)


General hypothermia in animals and man has been intensively investigated during the past ten years. The effects include lowering of the metabolic rate, slowing of the heart and respiration, decreased nervous conductivity and modifications of the electrolyte balance. Thus considerable changes of the “milieu interne” are taking place. The homeostatic derangement increases with decreasing temperatures and the biological limit to general hypothermia without the aid of extracorporeal circulation lies between 26–28° C. If lower temperatures are desirable without a cardiopulmonary by-pass, local cooling of separate organs may be the method of choice. The cooling is thereby confined to the structures for which the hypothermia is essential, the low temperatures may be obtained rapidly and a precise control of the temperature level is possible.


Brain Temperature Saccular Aneurysm Local Cool Extracorporeal Circuit Brain Cool 
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© Springer-Verlag/Wien 1964

Authors and Affiliations

  • K. Kristiansen
    • 1
  1. 1.Ullevål SykelusOslo, NorgeNorway

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