Pathophysiology of the Central Nervous System During Hypothermia

  • H. L. Rosomoff
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 13)


The hypothermic state may be divided into 4 stages: clinical, surgical, deep or profound, and frozen or supercooled. The clinical stage extends from 35° to 32° C, surgical from 32° to 25° C, deep or profound from 25° to 0° C, and the frozen or supercooled from 0° to—8° C. Each stage has characteristic physiological activities, and each, within prescribed limits, is compatible with survival and restoration of complete integrity upon rewarming. It is clear that the low temperature slows the rate of cellular processes and modifies the action of metabolities and other substances. This is not necessarily harmful, as long as anoxia and chemical imbalance do not develop.


Middle Cerebral Artery Left Middle Cerebral Artery Normal Body Temperature Cerebrospinal Fluid Pressure Hexose Monophosphate 
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  1. 1.
    Brown, D. E. S.: Some Considerations of Physiochemieal Factors in Hypothermia. The Physiology of Induced Hypothermia. NAS-NRC 451 (1956), 1–7.Google Scholar
  2. 2.
    Field, J., F. Fuhrman, and A. W. Martin: Effect of Tem-perature on the Oxygen Consumption of Brain Tissue. J. Neurophysiol. 7 (1944), 117–126.Google Scholar
  3. 3.
    Bosomoff, H. L., and D. A. Eoladay: Cerebral Blood Flow and Cerebral Oxygen Consumption during Hypothermia. Am. J. Physiol. 179 (1954), 85–88.Google Scholar
  4. 4.
    Bering, E. A., Jr.: Effect of Body Tempera-ture Change on Cerebral Oxygen Consumption of the Intact Monkey. Am. J. Physiol. 200 (1961), 417–419.Google Scholar
  5. 5.
    Bosomoff, H. L.: Hypothermia and Cerebral Vascular Lesions: I. Experimental Interruption of the Middle Cerebral Artery during Hypothermia. J. Neurosurg. 13 (1956), 244–255.Google Scholar
  6. 6.
    Bosomoff, H. L.: Hypothermia and Cerebral Vascular Lesions: II. Experi-mental Middle Cerebral Artery Interruption followed by Induction of Hypo-thermia. A. M. A. Arch. Neurol. Psychiat. 78 (1957), 454–464.Google Scholar
  7. 7.
    Bosomoff, H. L.: Experimental Brain Injury during Hypothermia. J. Neurosurg. 16 (1959), 177–187.CrossRefGoogle Scholar
  8. 8.
    Bosomoff, H. L.: Effect of Hypothermia and Hy-pertonic Urea on Distribution of Intracranial Contents. J. Neurosurg. 18 (1961), 753–759.CrossRefGoogle Scholar
  9. 9.
    Bosomoff, H. L., K. Shulman, B. Raynor, and W. Grainger: Experimental Brain Injury and Delayed Hypothermia. Surg. Gyn. Obst. 110 (1960), 27–32.Google Scholar

Copyright information

© Springer-Verlag/Wien 1964

Authors and Affiliations

  • H. L. Rosomoff
    • 1
  1. 1.Laboratory of Experimental Surgery (Neurological)The University of Pittsburgh School of Medicine and The Veterans Administration HospitalPittsburghUSA

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