Pathophysiology of the Central Nervous System During Hypothermia

  • H. L. Rosomoff
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 13)


The hypothermic state may be divided into 4 stages: clinical, surgical, deep or profound, and frozen or supercooled. The clinical stage extends from 35° to 32° C, surgical from 32° to 25° C, deep or profound from 25° to 0° C, and the frozen or supercooled from 0° to—8° C. Each stage has characteristic physiological activities, and each, within prescribed limits, is compatible with survival and restoration of complete integrity upon rewarming. It is clear that the low temperature slows the rate of cellular processes and modifies the action of metabolities and other substances. This is not necessarily harmful, as long as anoxia and chemical imbalance do not develop.


Middle Cerebral Artery Left Middle Cerebral Artery Normal Body Temperature Cerebrospinal Fluid Pressure Hexose Monophosphate 


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Copyright information

© Springer-Verlag/Wien 1964

Authors and Affiliations

  • H. L. Rosomoff
    • 1
  1. 1.Laboratory of Experimental Surgery (Neurological)The University of Pittsburgh School of Medicine and The Veterans Administration HospitalPittsburghUSA

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