Iwanowski (1903) was probably the first to point out that certain abnormal intracellular inclusions were always present in some cells of mosaic-infected tobacco plants. We now know that these abnormal inclusions are characteristic of virus infections and do not occur in diseases caused by other infectious agents. Whilst they are not found in all virus diseases, they are invariably present in those in which they do occur. After Iwanowski’s discovery the next worker to find similar inclusions was probably Matz (1919) who found plasmodium-like masses in the cells of mosaic-infected sugar cane. In 1921, Kunkel described intracellular inclusions similar to those described by Iwanowski, in maize affected with a mosaic disease. Shortly after this, Smith (1924) reported the occurrence of amoeboid bodies in the cells of potato plants infected with mild mosaic (potato virus X). Since those days many other workers have described similar inclusions in the cells of plants infected with virus diseases. Among these other early workers may be mentioned the following: Goldstein (1927) made an extensive study of the inclusion bodies in Dahlia plants affected with mosaic and dwarf; Hoggan (1927) investigated the inclusions in solanaceous plants infected with several different viruses; F. F. Smith (1926) reported on intracellular inclusions in mosaic tobacco and in the chlorotic areas of mosaic Datura. Henderson Smith (1930) made a careful study of the inclusions caused by tomato aucuba mosaic virus in Solanum nodiflorum.


Sugar Cane Virus Particle Tobacco Mosaic Virus Intranuclear Inclusion Mosaic Disease 
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Copyright information

© Springer-Verlag in Vienna 1958

Authors and Affiliations

  • Kenneth M. Smith
    • 1
  1. 1.Virus Research Unit (Agricultural Research Council), Molteno InstituteCambridge UniversityCambridgeUK

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