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Multiple Opiate Receptors and Their Functional Significance

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Basic Aspects of Receptor Biochemistry

Part of the book series: Journal of Neural Transmission ((NEURAL SUPPL,volume 18))

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Summary

There is ample evidence from studies of peripheral isolated organs, binding of opiate receptor ligands to brain membranes and behavioural experiments that opiate receptors are not homogeneous but consist of different types such as the μ- (= morphine), δ- (= enkephalin), ϰ- (= ketocyclazocine) and the ε- (= β-endorphin) receptors. In addition, there are indications for subtypes within the particular classes of receptors, at least in the case of μ-land ϰ-receptors. In one organ or particular brain structure, several types of receptors can be present—though big differences in the relative concentrations between various brain areas exist. The precise nature of the relationship between the multiplicity of opiate receptors and the multiplicity of endogenous opioids is not clear. The enkephalins and dynorphin appear to be, however, related to, respectively, δ- and ϰ-receptors. According to our present knowledge, there is no strict relationship between certain physiological functions (or pharmacological actions) and the activation of a particular receptor type; for example, μ-, δ- and ϰ-receptors are involved in pain modulation.

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Author information

Authors and Affiliations

  1. Abteilung für Neuropharmakologie, Max-Planck-Institut für Psychiatrie, Kraepelinstrasse 2, D-8000, München 40, Federal Republic of Germany

    Prof. Dr. A. Herz

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  1. Prof. Dr. A. Herz
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Editors and Affiliations

  1. Department of Psychiatry, New York University Medical Center, New York, N.Y., USA

    Menek Goldstein

  2. Ludwig Boltzmann-Institut für Klinische Neurobiologie und Neurologische Abteilung, Krankenhaus der Stadt Wien-Lainz, Wien, Austria

    Kurt Jellinger

  3. Ludwig Boltzmann-Institut für Klinische Neurobiologie, Krankenhaus der Stadt Wien-Lainz, Wien, Austria

    Peter Riederer

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© 1983 Springer-Verlag Wien

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Herz, A. (1983). Multiple Opiate Receptors and Their Functional Significance. In: Goldstein, M., Jellinger, K., Riederer, P. (eds) Basic Aspects of Receptor Biochemistry. Journal of Neural Transmission, vol 18. Springer, Vienna. https://doi.org/10.1007/978-3-7091-4408-4_21

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  • DOI: https://doi.org/10.1007/978-3-7091-4408-4_21

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-4410-7

  • Online ISBN: 978-3-7091-4408-4

  • eBook Packages: Springer Book Archive

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