Advertisement

Activation of Influenza Virus Infectivity by Proteolytic Cleavage of the Hemagglutinin

  • Rudolf Rott
  • Hans-Dieter Klenk
  • Christoph Scholtissek
Part of the Topics in Infectious Diseases book series (TIDIS, volume 3)

Abstract

It is reasonable to assume that a virus disease is manifest in a clinical sense, if cells of vital functional significance are infected by the virus and are killed or at least modified by this infection. Since the tropism of a virus for a host cell represents primarily an interaction between the surface components of the virus and receptors of the cell it is appealing to postulate that structures of a virus surface might determine the infectivity and pathogenic properties of the virus. The results of our experiments have to be interpreted in this sense, because we could demonstrate such an inter-relationship for the hemagglutinin of influenza virus.

Keywords

Influenza Virus Newcastle Disease Virus Infectious Virus Progeny Virus Embryo Chicken Fibroblast 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. KLENK, H-D. and ROTT, R. (1973) J. Virol. 11, 823–831.PubMedGoogle Scholar
  2. KLENK, H-D., ROTT, R. and ORLICH, M. (1977) J. Gen. Virol., in press.Google Scholar
  3. KLENK, H-D., ROTT, R., ORLICH, M. and BLÖDORN, J. (1975) Virology, 68, 426–439.PubMedCrossRefGoogle Scholar
  4. KLENK, H-D., WÖLLERT, W., ROTT, R. and SCHOLTISSEK, C. (1974) Virology, 57, 28–41.PubMedCrossRefGoogle Scholar
  5. LAZAROWITZ, S. G. and CHOPPIN, P. W. (1975) Virology, 68, 440–454.PubMedCrossRefGoogle Scholar
  6. LAZAROWITZ, S. G., COMPANS, R. W. and CHOPPIN, P. W. (1971) Virology, 46, 830–843.PubMedCrossRefGoogle Scholar
  7. LAZAROWITZ, S. G., COMPANS, R. W. and CHOPPIN, P. W. (1973) Virology, 52, 199–212.PubMedCrossRefGoogle Scholar
  8. ROTT, R. and KLENK, H-D. (1977) in `Cell Surface Reviews’ (eds., G. Poste and G. L. Nicolson), North Holland Publ. Comp., Amsterdam. Vol. 2, pp. 47. 81.Google Scholar
  9. ROTT, R., ORLICH, M. and SCHOLTISSEK, C. (1976) J. Virol., 19, 54–60.PubMedGoogle Scholar
  10. SCHOLTISSEK, C., HARMS, H., ROHDE, W., ORLICH, M. and ROTT, R. (1976) Virology, 74, 332–344.PubMedCrossRefGoogle Scholar
  11. SCHOLTISSEK, C., ROTT, R., ORLICH, M., HARMS, E.and ROHDE, W. (1977) Virology, in press.Google Scholar

Copyright information

© Springer-Verlag Wien 1978

Authors and Affiliations

  • Rudolf Rott
  • Hans-Dieter Klenk
  • Christoph Scholtissek

There are no affiliations available

Personalised recommendations