Activation of Influenza Virus Infectivity by Proteolytic Cleavage of the Hemagglutinin
It is reasonable to assume that a virus disease is manifest in a clinical sense, if cells of vital functional significance are infected by the virus and are killed or at least modified by this infection. Since the tropism of a virus for a host cell represents primarily an interaction between the surface components of the virus and receptors of the cell it is appealing to postulate that structures of a virus surface might determine the infectivity and pathogenic properties of the virus. The results of our experiments have to be interpreted in this sense, because we could demonstrate such an inter-relationship for the hemagglutinin of influenza virus.
KeywordsInfluenza Virus Newcastle Disease Virus Infectious Virus Progeny Virus Embryo Chicken Fibroblast
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