The Delineation of Antigenic Determinants of the Hemagglutinin of Influenza a Viruses by Means of Monoclonal Antibodies

  • Walter Gerhard
Part of the Topics in Infectious Diseases book series (TIDIS, volume 3)


The antigenicity of various viral hemagglutinins (HA) of the HO and H1 subtypes was analyzed by means of monoclonal anti-HA antibodies of BALB/c origin which were produced in vitro. Anti-HA(PR8) antibodies were able to discriminate 44 (groups of) determinants, one specific for the HA of PR8 and the others present (in a crossreactive form) on a variable number of HA of the heterologous influenza virus strains. It was estimated that the 9 antigenically related HA included in the analysis represent a minimum of (2)7 antigenic determinants that are recognized by the BALB/c immune system, implying that the individual HA may contain approximately 15 to 65 distinct determinants.


Reactivity Type Antibody Clone Antigenic Determinant Antibody Population Antigenic Analysis 
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© Springer-Verlag Wien 1978

Authors and Affiliations

  • Walter Gerhard

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