Studies on the Primary Structure of the Hemagglutinin from an H3N2 Variant a/Memphis/102/72

  • Theo A. A. Dopheide
  • Colin W. Ward
Part of the Topics in Infectious Diseases book series (TIDIS, volume 3)


Pathogens responsible for chronic or repeated infections evade the immune response by either the adsorption of host antigens, as in schistosomiasis (Clegg, 1974), the release of soluble surface antigens, as with maleria, Babesia and nematode infections, (Wilson, 1974) or by a process of antigenic variation, as in trypanosomiasis and influenza. In trypanosomiasis, antigenic variation is phenotypic and involves the sequential expression of alternative genes (Bridgen and Cross, 1976). In influenza, antigenic variation was also once thought to be phenotypic, the virion supposedly possessing a mosaic of antigens variably exposed in different strains (see Fazekas de St. Groth, 1970; Webster and Laver, 1975, for reviews). However the wealth of information published on the biology, structure, chemistry and immunology of influenza virus over the last fifteen years has established beyond doubt that antigenic variability in influenza is genetic (Kilbourne, 1975).


Influenza Virus Amino Acid Composition Antigenic Variation Cyanogen Bromide Carbohydrate Composition 
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© Springer-Verlag Wien 1978

Authors and Affiliations

  • Theo A. A. Dopheide
  • Colin W. Ward

There are no affiliations available

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