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’N-Terminal Amino Acid Analysis of Hemagglutinin Molecules from Duck and Equine Influenza Viruses Previously Implicated as Progenitors of the Hong Kong Strain of Human Influenza

  • W. G. Laver
  • R. G. Webster
Part of the Topics in Infectious Diseases book series (TIDIS, volume 3)

Summary

The hemagglutinin molecules from a number of strains of influenza virus, including those of the Asian (H2N2) series, have been found to possess N-terminal aspartic acid (or asparagine) at the N-terminus of the large polypeptide (HA1). The only virus strains found so far which do not possess N-terminal aspartic acid on the hemagglutinin are those of the Hong Kong (H3N2) series, where the N-terminus seems to be blocked.

We have found that the hemagglutinin molecules of equine-2 (Heq2Neq2) and duck/Ukraine (Hav7Neq2) viruses also lack N-terminal aspartic acid. This finding is consistant with the idea that the hemagglutinin molecules of Hong Kong influenza virus were derived, by genetic recombination, from a virus related to equine-2 and duck/Ukraine viruses and that they did not arise by mutation of an Asian (H2N2) influenza virus.

Keywords

Influenza Virus Guanidine Hydrochloride Blue Filter Precursor Polypeptide Equine Influenza Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Wien 1978

Authors and Affiliations

  • W. G. Laver
  • R. G. Webster

There are no affiliations available

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