Preliminary Studies of the Membrane-Associated Portion of the Hemagglutinin

  • D. C. Wiley
  • J. J. Skehel
Part of the Topics in Infectious Diseases book series (TIDIS, volume 3)


Like other ‘intrinsic’ membrane proteins the hemagglutinin is amphipathic. The results of comparative analyses of intact hemagglutinin molecules and preparations which lack the membrane associated hydrophobic region indicate that the portion of the molecule associated with the lipid bilayer is near the COOHterminus of the smaller polypeptide component, HA2 (Skehel and Waterfield, 1975).


Influenza Virus Sucrose Density Gradient Centrifugation Detergent Micelle Chick Embryo Fibroblast Influenza Virus Hemagglutinin 


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  1. Skehel, J. J. and Waterfield, M. D. (1975). Proc. Nat. Acad. Sci. U.S., 72, 93–97.CrossRefGoogle Scholar
  2. Helenius, A. and Simons, K. (1977) Proc. Nat. Acad. Sci. Usa. 74, 529–532.CrossRefGoogle Scholar

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© Springer-Verlag Wien 1978

Authors and Affiliations

  • D. C. Wiley
  • J. J. Skehel

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