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The Prognostic Value of Osmolality Within the First Week of Sustaining Head Injury

  • M. Gaab
  • H. A. Trost
  • K. W. Pflughaupt
Conference paper
Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 28)

Abstract

On sustaining severe brain damage, there generally follow disturbances of metabolic regulation. The latter is a central function of the diencephalon10 and brain stem7. Thus several groups have monitored various blood metabolites e.g. hyperglycaemia12, azotaemia2, lactatepyruvate8, proteins2, 4 and lipids3 with regard to prognosis after head injury. However, though mentioned2,12, blood and CSF osmolality have not been systematically investigated despite the known role of the diencephalon in osmoregulation13,15 . We therefore investigated the course of blood and CSF osmolalities, correlating them with clinical and other biochemical data.

Keywords

Head Injury Plasma Osmolality Severe Head Injury Severe Brain Injury Urine Specific Gravity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Arieff, A. I., Kleeman, C. R., Studies on mechanism of cerebral edema in diabetic coma. J. Clin. Invest. 52 (1973), 571 583.Google Scholar
  2. 2.
    Auer, L., Holzer, H., Tritthart, H., Gell, G., Azotaemia in severe head injury-central dysregulation or renal failure? Acta Neurochir. (Wien) 41 (1978), 355–361.CrossRefGoogle Scholar
  3. 3.
    Auer, L., Marth, E., Petek, W., Holzer, H., Gell, G., The prognostic value of biochemical data from blood and CSF: Analysis in patients with severe head injury. In: Frowein, R. A., Wilcke, O., Karimi-Nejad, A., Brock, M., Klinger, M., eds. Advances in Neurosurgery, Vol. 5, Head Injuries-Tumors of the cerebellar region, pp. 132–137. Berlin-Heidelberg-New York: Springer. 1978.CrossRefGoogle Scholar
  4. 4.
    Auer, L., Petek, W., Serumproteinveränderungen bei Patienten mit Schädelhirntrauma. Acta Neurochir. (Wien) 33 (1976), 301–309.CrossRefGoogle Scholar
  5. 5.
    Gaab, M., Knoblich, O. E., Dietrich, K., Gruss, P., Miniaturized methods of monitoring intracranial pressure in craniocerebral trauma before and after operation. In: Frowein, R. A., Wilcke, O., Karimi-Nejad, A., Brock, M., Klinger, M., eds. Advances in Neurosurgery, Vol. 5, Head Injuries-Tumors of the cerebellar region, pp. 5–11. Berlin-Heidelberg-New York: Springer. 1978.CrossRefGoogle Scholar
  6. 6.
    Gaab, M., Pflughaupt, K. W., Ratzka, M., Wodarz, R., Gruss, P., Critical intracranial effects of osmotherapy. In: Wüllenweber, R., Wenker, H., Brocl, M., Klinger, M., eds. Advances in Neurosurgery, Vol. 6, Treatment of Hydrocephalus-Computer Tomography, pp. 193–205. Berlin-Heidelberg-New York: Springer. 1978.CrossRefGoogle Scholar
  7. 7.
    Gerstenbrand, F., Lücking, C. H., Die akuten traumatischen Hirnstammschäden. Acta Psychiatr. Nervenkr. 213 (1970), 264–281.CrossRefGoogle Scholar
  8. 8.
    Hausdörfer, J., Heller, W., Oldenkott, P., Stolz, I. C., Alterations of metabolism in brain edema following head injury. In: Schürmann, K., Brock, M., Reulen, H. J., Voth, D., eds. Advances in Neurosurgery, Vol. 1, Brain Edema-Cerebello Pontine Angle Tumors, pp. 34–41. BerlinHeidelberg-New York: Springer. 1973.CrossRefGoogle Scholar
  9. 9.
    Hausdörfer, J., Heller, W., Junger, H., Preger, R., Veränderungen des Lipidstoffwechsels nach akuten experimentellen Schädel-Hirn-Traumen. Med. Welt 27 (1976), 426–431.PubMedGoogle Scholar
  10. 10.
    Hess, W. R., Das Zwischenhirn. Syndrome, Lokalisation und Funktionen, 2. Aufl. Basel: Schwabe. 1954.Google Scholar
  11. 11.
    Jennett, B., Bond, M., Assessment of outcome after severe brain damage. Lancet II (1975), 480–485.Google Scholar
  12. 12.
    Park, B. E., Meacham, W. F., Netsky, M. G., Nonketotic hyperglycemic coma. Report of neurosurgical cases with a review of mechanisms and treatment. J. Neurosurg. 44 (1976), 409–417.PubMedCrossRefGoogle Scholar
  13. 13.
    Schmidt-Nielsen, B. M., Mackay, W. C., Comparative physiology of electrolyte and water regulation. In: Morten, M. H., Kleeman, C. R., eds. Clinical disorders of fluid and elctrolyte metabolism, 2. ed., pp. 45–93. New York: McGraw-Hill. 1972.Google Scholar
  14. 14.
    Vapalahti, M., Troupp, H., Prognosis for patients with severe brain injuries. Brit. Med. J. 3 (1971),404–407.Google Scholar
  15. 15.
    Verney, E. B., The antidiuretic hormone and the factors which determine its release. Proc. roy. Soc. B 136 (1947),25–106.Google Scholar

Copyright information

© Springer-Verlag Wien 1979

Authors and Affiliations

  • M. Gaab
    • 1
  • H. A. Trost
    • 1
  • K. W. Pflughaupt
    • 1
  1. 1.Neurosurgical Clinic of the University of WürzburgFederal Republic of Germany

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