The Local Anaesthetic Action of Metipranolol Versus Timolol in Patients with Healthy Eyes

  • J. Draeger
  • R. Winter
Conference paper


In the last few years the topical use of beta-receptor blocking agents to reduce intraocular pressure has gained ground considerably. Wide usage of the first products of this type was, however, hampered by the local anaesthetic side effect on the cornea, as beta-receptor blocking agents have a chemical structure that is similar to that of local anaesthetics. This also partly explains their membrane-stabilizing activity. As far back as 1972 Vale et al., when using propranolol topically, described this unexpected side effect, i. e. a topical anaesthesia of the cornea. The classical type of anaesthetics with a topical action is composed of
  1. 1.

    a secondary or tertiary amino group,

  2. 2.

    a polar carboxy oxygen that may belong to an ester or acid amide and

  3. 3.

    an apolar ring.



Local Anaesthetic Effect Local Anaesthetic Action Acid Amide Sensitivity Threshold Corneal Sensitivity 
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Copyright information

© Springer-Verlag Wien 1984

Authors and Affiliations

  • J. Draeger
    • 1
    • 2
  • R. Winter
    • 1
    • 2
  1. 1.University Eye ClinicHamburgFederal Republic of Germany
  2. 2.Universitäts-Augenklinik HamburgHamburgFederal Republic of Germany

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