Advertisement

The Local Anaesthetic Action of Metipranolol Versus Timolol in Patients with Healthy Eyes

  • J. Draeger
  • R. Winter
Conference paper

Abstract

In the last few years the topical use of beta-receptor blocking agents to reduce intraocular pressure has gained ground considerably. Wide usage of the first products of this type was, however, hampered by the local anaesthetic side effect on the cornea, as beta-receptor blocking agents have a chemical structure that is similar to that of local anaesthetics. This also partly explains their membrane-stabilizing activity. As far back as 1972 Vale et al., when using propranolol topically, described this unexpected side effect, i. e. a topical anaesthesia of the cornea. The classical type of anaesthetics with a topical action is composed of
  1. 1.

    a secondary or tertiary amino group,

     
  2. 2.

    a polar carboxy oxygen that may belong to an ester or acid amide and

     
  3. 3.

    an apolar ring.

     

Keywords

Local Anaesthetic Effect Local Anaesthetic Action Acid Amide Sensitivity Threshold Corneal Sensitivity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bleckmann, H., Pham Duy, T., Grajewski, O.: Therapeutische Wirksamkeit von Metipranolol-AT 0,3 %/Timolol-AT 0,25 %. In: Metipranolol-Symposium. Berlin, 1983. (In this book, pp. 106–120.)Google Scholar
  2. 2.
    Buhr-Unger, H., Draeger, J., Luders, M.: Untersuchungen zur lokalanästhetischen Wirkung der Beta-Rezeptorenblocker. Ber. Dtsch. Ophthalmol. Ges. 77, 577–581 (1980).CrossRefGoogle Scholar
  3. 3.
    Dausch, D., Brewitt, H., Edelhoff, R.: Metipranolol-Augentropfen - Klinische Verwendbarkeit bei der Behandlung des chronischen Offenwinkelglaukoms. In: Metipranolol-Symposium. Berlin, 1983. (In this book, pp. 132–147.)Google Scholar
  4. 4.
    von Denffer, H.: Wirksamkeit und Verträglichkeit von Metipranolol - Ergebnisse einer multizentrischen Langzeitstudie. In: MetipranololSymposium. Berlin, 1983. (In this book, pp. 121–125.)Google Scholar
  5. 5.
    Draeger, J., Koudelka, A., Lubahn, E.: Zur Aesthesiometrie der Hornhaut. Klin. Mbl. Augenheilk. 169, 407–421 (1976).PubMedGoogle Scholar
  6. 6.
    Draeger, J., Langenbucher, H., Luders, M., Banner, W.: Zur Wirkung von Oberflächenanaesthetika am Auge. Klin. Mbl. Augenheilk. 177, 780–788 (1980).PubMedCrossRefGoogle Scholar
  7. 7.
    Frey, M. von: Beiträge zur Physiologie des Schmerzsinnes. In: Berichte über die Verhandlungen der Königlich-Sächsischen Ges. der Wissenschaften zu Leipzig, Math. Classe. Leipzig: Hirzel. 1894.Google Scholar
  8. 8.
    Krieglstein, G. H.: The intraocular response of glaucomatous eyes to topical applied bupranolol. A pilot study. Graefes Arch. Klin. Exp. Ophthalmol. 202, 81 (1977).Google Scholar
  9. 9.
    Krieglstein, G. K.: Die Wirkung von Timolol-Augentropfen auf den Augeninnendruck bei Glaucoma simplex. Klin. Mbl. Augenheilk. 172, 677–685 (1978).PubMedGoogle Scholar
  10. 10.
    Krieglstein, G. K.: Prinzipien klinischer Arzneimittelprüfung. In: Metipranolol-Symposium. Berlin, 1983. (In this book, pp. 71–75.)Google Scholar
  11. 11.
    Kruse, W.: Ergebnisse einer Langzeitstudie mit Metipranolol. In: Metipranolol-Symposium. Berlin, 1983. (In this book, pp. 126–131.)Google Scholar
  12. 12.
    Mertz, M:. Ergebnisse einer multizentrischen Doppelblindprüfung Metipranolol/Timolol über 6 Wochen. In: Metipranolol-Symposium. Berlin, 1983. (In this book, pp. 93–105.)Google Scholar
  13. 13.
    Nielsen, N. V.: Timolol. Hypotensive effect used alone and in combination for treatment of increased intraocular pressure. Acta Ophthalmol. 56, 504–508 (1978).Google Scholar
  14. 14.
    Vale, J., Gibbs, A., Phillips, C.: Topical propranolol and ocular tension in the human. Brit. J. Ophthalmol. 56, 770–775 (1972).CrossRefGoogle Scholar
  15. 15.
    Zimmermann, T. J., Kaufman, H. E.: Timolol, a beta-adrenergic blocking agent for the treatment of glaucoma. Arch. Ophthalmol. 95, 601–607 (1977).CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 1984

Authors and Affiliations

  • J. Draeger
    • 1
    • 2
  • R. Winter
    • 1
    • 2
  1. 1.University Eye ClinicHamburgFederal Republic of Germany
  2. 2.Universitäts-Augenklinik HamburgHamburgFederal Republic of Germany

Personalised recommendations