Pathophysiological Changes in Coagulation and Fibrinolysis in SAH

Abstract

It is known that after bleeding into the subarachnoid space farreaching changes in coagulation may occur sporadically ^{88, 94, 152, 279} Hence, a follow-up study about the relationships as they prevail in haemostasis is required in order possibly to initiate a substitution therapy or an effective systemic haemostyptic therapy ^{168, 204, 268, 305} The platelets especially and the fibrinogen, which together deliver the anatomical substrate for the rapid obliteration of a ruptured aneurysm should, together with the extrinsic and intrinsic coagulation pathway, show no departure from the usual pattern.