Definition of the Problems

Abstract

The great efforts made in quantitative recording of the clotting and fibrinolytic relations in the CSF by means of selective analyses including objective data acquisition have in recent years brought about clarification of the haemostatic pathway with both a normal and a disturbed BBB function. It is the object of the present report ¹⁰⁵ to revise the more or less accidental sporadic, and sometimes, contradictory results obtained in clinical research, and to complete them in accordance with the present state of knowledge, on a pathophysiological basis. In doing so, normal, inflammatorily changed and blood-stained CSF had been classified prospectively, and the activators, inhibitors, zymogens, active enzymes, the substrate and its degradation products from the haemostatic system, have been determined quantitatively.